Yazar "Özkan, Sibel Ayşıl" için listeleme
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Functionalized carbon nanotubes - With silver nanoparticles to fabricate a sensor for the determination of zolmitriptan in its dosage forms and biological samples
A simple, sensitive and reproducible silver nanoparticle/multi walled carbon nanotubes modified glassy carbon electrode was developed as a sensor for the voltammetric determination of zolmitriptan with good accuracy and ... -
Investigation of voltammetric behavior and electroanalytical determination of anticancer epirubicin via glassy carbon electrode using differential pulse and square wave voltammetry techniques
Kurbanoğlu, Sevinç; Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Editions de l'Academie Republique Populaire, 2015)The electrochemical oxidation of epirubicin was investigated using cyclic, differential pulse and square wave voltammetry at glassy carbon electrode. The aim of the study was to determine epirubicin levels in pharmaceuticals ... -
Modern Assay Techniques for Cancer Drugs: Electroanalytical and Liquid Chromatography Methods
Kurbanoğlu, Sevinç; Karadaş Bakırhan, Nurgül; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (Taylor and Francis Ltd., 2018)In the past decades, patients who have chemotherapy treatment have considerably increased number. At this point, the development of rapid precise, and reliable methods are very important to analyze cancer drugs from their ... -
Nanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic Techniques
Şengel Türk, Ceyda Tuba; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Elsevier, 2017)Cancer is the primary leading cause of mortality in the world. The key of a successful cancer treatment depends on many important parameters, such as the application route, anticancer compound, and dosage form. Among the ... -
A novel core-shell-based chromatographic method supported by ratio derivative spectrophotometry for the simultaneous determination of perindopril, indapamide, and amlodipine ternary mixtures
Karadurmuş, Leyla; Gümüştaş, Mehmet; Kurbanoğlu, Sevinç; Uslu, Bengi; Özkan, Sibel Ayşıl (TUBİTAK, 2018)In this work, ratio spectra of the frst derivative spectrophotometric and liquid chromatographic methods have been described for the frst time for the simultaneous determination of perindopril (PER), indapamide (IND), and ... -
A novel RP-LC method for determination of pK a values of some anticancer agents and their assay
A simple, reliable, and rapid RP-LC method has been developed for the determination of some anticancer drugs (daunorubicin, doxorubicin and vincristine sulfate) in their dosage forms and human urine. These compounds are ... -
Optimization of stability indicating LC method for the sensitive in vitro determination from solid lipid nanoparticles and ex vivo analysis from rat skin of etofenamate
Gümüştaş, Mehmet; Şengel Türk, Ceyda Tuba; Badıllı, Ulya; Amasya, Gülin; Özkan, Sibel Ayşıl; Tarımcı, Nilüfer (Bentham Science Publishers B.V., 2017)Introduction: Etofenamate (2-(2-hydroxyethoxy) ethyl 2-[[3-(trifluoromethyl)phenyl]amino] benzoate) (ETO) is a yellowish viscous liquid which is a nonsteroidal anti-inflammatory drug (NSAID) that has been applied topically ... -
Polarographic investigation of dienogest
Baymak Çelik, Melek Şirin; Çelik, Hayati; Karadaş Bakırhan, Nurgül; Uslu, Bengi; Özkan, Sibel Ayşıl (Electrochemical Society Inc., 2018)Dienogest (DGN), is an orally administered synthetic progestin that has shown to have selective progesterone receptor (PR) agonistic activity and oral progestational potency on endometrium. In this paper, the investigation ... -
Recent progress on the sensitive detection of cardiovascular disease markers by electrochemical-based biosensors
Karadaş Bakırhan, Nurgül; Özçelikay, Göksu; Özkan, Sibel Ayşıl (Elsevier B.V., 2018)Cardiovascular disease is the most reason for deaths in all over the world. Hence, biomarkers of cardiovascular diseases are very crucial for diagnosis and management process. Biomarker detection demand is opened the ... -
The redox mechanism investigation of non-small cell lung cancer drug: Erlotinib via theoretical and experimental techniques and its host–guest detection by β-Cyclodextrin nanoparticles modified glassy carbon electrode
Karadaş Bakırhan, Nurgül; Taşkın Tok, Tuğba; Özkan, Sibel Ayşıl (Elsevier B.V., 2019)Erlotinib (ERL) is a tyrosine kinase inhibitor which prevents growing of cancer cells. The electrochemical oxidation mechanism of ERL was studied in details using cyclic voltammetry. Cyclic voltammetry, differential pulse ... -
Selective and sensitive determination of repaglinide in pharmaceuticals by voltammetric and LC methods
Gümüştaş, Mehmet; Coşkun, Gökçe; Özkan, Sibel Ayşıl (Editions de l'Academie Republique Populaire, 2015)Detailed electrochemical study and novel voltammetric and LC methods are presented for the determination of repaglinide (RPG) in pharmaceuticals. Repaglinide in methanol: buffer solution (20:80; v/v) shows one or two anodic ... -
A sensitive and selective RP-LC method for the simultaneous determination of the antihypertensive drugs, enalapril, lercanidipine, nitrendipine and their validation
A RP-LC method is presented, which is sensitive and selective for the simultaneous determination of enalapril-lercanidipine and enalapril-nitrendipine binary mixtures in their pharmaceutical dosage forms. The analyte peaks ... -
Separation and elution order of the enantiomers of some beta-agonists using polysaccharide-based chiral columns and normal phase eluents by high-performance liquid chromatography
Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Chankvetadze, Bezhan (Elsevier B.V., 2016)In this study separation of enantiomers of 8 chiral ?-agonists were studied on 6 polysaccharide-based chiral columns in polar-organic and alcohol-hydrocarbon mobile phases. No separation of enantiomers was observed on any ... -
Simple and sensitive adsorptive stripping voltammetric assay of granisetron from its dosage form by platinum nanoparticles modified electrodes
Doulache, Merzak; Karadaş Bakırhan, Nurgül; Uslu, Bengi; Saidat, Boubakeur; Trari, Mohamed; Özkan, Sibel Ayşıl (Elsevier B.V., 2017)Base to the interfacial adsorptive nature of granisetron (GRN) on platinum particles modified glassy carbon electrode (PtPs/GCE). A sensitive analytical method for trace analysis of GRN based on the adsorptive stripping ... -
Simple, sensitive and reliable LC-DAD method of gemifloxacin determination in pharmaceutical dosage forms
Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (2012)A sensitive, accurate, rapid, fully validated, reliable and easy method was developed for the quantification of gemifloxacin mesylate (GEM) using liquid chromatography (LC) with DAD detection. In this method; a reversed-phase ... -
Simultaneous determination and validation of emtricitabine, rilpivirine and tenofovir from biological samples using LC and CE methods
Gümüştaş, Mehmet; Çağlayan, Mehmet Gökhan; Onur, Feyyaz; Özkan, Sibel Ayşıl (John Wiley and Sons Ltd, 2018)A combination of antiretroviral agents is frequently used in effective treatment of the human immunodeficiency virus infection. In this study, two different separation methods are presented for the simultaneous determination ... -
Simultaneous determination and validation of some binary mixtures of antihypertensive drugs using ratio derivative spectrophotometric method
Kurbanoğlu, Sevinç; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (Maik Nauka Publishing / Springer SBM, 2014)Ratio derivative spectrophotometric technique is presented for the rapid, accurate and precise simultaneous determination of olmesartan medoxomil (OLM), hydrochlorothiazide (HCT), and zofenopril (ZOF) as well as HCT binary ... -
Simultaneous determination of amlodipine besylate and rosuvastatin calcium in binary mixtures by voltammetric and chromatographic techniques
Karadaş Bakırhan, Nurgül; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Institute for Ionics, 2016)Voltammetric and liquid chromatographic (LC) methods have been developed for the simultaneous determination of amlodipine besylate (AML) and rosuvastatin calcium (ROS) for the first time. Detailed electrochemical behavior ... -
Simultaneous estimation of ceftazidime and ceftizoxime in pharmaceutical formulations by HPLC method
Şanlı, Senem; Şanlı, Nurullah; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Karadaş, Nurullah; Aboul-Enein, Hassan Y. (2011)The aim of the present study was to develop a fast, sensitive and reliable method for rapid screening of cephalosporin injectable dosage forms namely ceftazidime and ceftizoxime to the detection of counterfeit and substandard ... -
UPLC versus HPLC on drug analysis: Advantageous, applications and their validation parameters
Liquid chromatography (LC) is a separation technique used in many different areas to aid the identification and quantification of substances in various matrices. LC techniques with various detection modes have been widely ...