Yazar "Gümüştaş, Mehmet" için listeleme
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Analytical and preparative scale separation of enantiomers of chiral drugs by chromatography and related methods
Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Chankvetadze, Bezhan (Bentham Science Publishers B.V., 2018)While the amino acids, enzymes and hormones are chiral, chirality plays significant role in the life of plants, animals, as well as the human being. Chirality of molecules is important in various industries, such as ... -
Determination of pK a values of cefdinir and cefixime by LC and spectrophotometric methods and their analysis in pharmaceutical dosage forms
Şanlı, Nurullah; Şanlı, Senem; Sızır, Ümit; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (Friedr. Vieweg und Sohn Verlags GmbH, 2011)The pK a values of cefdinir and cefixime, which are used in the treatment of bacterial infections, have been determined precisely in water and methanol-water binary mixtures (20% v/v) using spectrophotometric titration and ... -
Determination of pKa values of some antihypertensive drugs by liquid chromatography and simultaneous assay of lercanidipine and enalapril in their binary mixtures
Gümüştaş, Mehmet; Şanlı, Senem; Şanlı, Nurullah; Özkan, Sibel Ayşıl (Elsevier B.V., 2010)In this study, pKa values were determined using the dependence of the retention factor on the pH of the mobile phase for three ionizable substances, namely, enalapril, lercanidipine and ramipril (IS). The effect of the ... -
Development and validation of a liquid chromatographic method for concurrent assay of weakly basic drug verapamil and amphoteric drug trandolapril in pharmaceutical formulations
The analysis of weakly basic drugs such as verapamil by reverse-phase liquid chromatography remains a problem, particularly when present in combination with other drugs such as amphoteric compounds like trandolapril. In ... -
Development and validation of a stability-indicating RP-LC method for the determination of anticancer drug epirubicin in pharmaceuticals
Kurbanoğlu, Sevinç; Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Şanlı, Senem; Uslu, Bengi; Özkan, Sibel Ayşıl (Taylor and Francis Inc., 2014)In the present paper, sensitive, rapid, and different analytical methodology was developed for the determination of anticancer drug epirubicin (EPR). The mixture of epirubicin and moxifloxacin as internal standard was ... -
Development of a HILIC method for the determination of 5-fluorouracil from nano drug delivery systems and rat skin extracts
Amasya, Gülin; Gümüştaş, Mehmet; Badıllı, Ulya; Özkan, Sibel Ayşıl; Tarımcı, Nilüfer (Elsevier B.V., 2018)This is the first report in literature using hydrophilic interaction liquid chromatography (HILIC) in combination with diode array detector (DAD) for stability indicating determination of 5-Fluorouracil (5-FU) from its ... -
Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes
Kul, Dilek; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Elsevier B.V., 2010)Ziprasidone is a psychotropic agent used for the treatment of schizophrenia. Its oxidation was investigated electrochemically at boron-doped diamond and glassy carbon electrodes using cyclic, differential pulse, and square ... -
Electrochemical approach for the sensitive determination of anticancer drug epirubicin in pharmaceuticals in the presence of anionic surfactant
Bozal Palabıyık, Burçin; Kurbanoğlu, Sevinç; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Editions de l'Academie Republique Populaire, 2013)In this research, sensitive, rapid, different electrochemical methods were developed for the determination of anticancer drug epirubicin. The aim of the study was to fully validated determination of epirubicin in ... -
Electrochemical evaluation and determination of antiretroviral drug fosamprenavir using boron-doped diamond and glassy carbon electrodes
Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (2010)Fosamprenavir is a pro-drug of the antiretroviral protease inhibitor amprenavir and is oxidizable at solid electrodes. The anodic oxidation behavior of fosamprenavir was investigated using cyclic and linear sweep voltammetry ... -
Erratum to: UPLC versus HPLC on drug analysis: advantageous, applications and their validation parameters
The authors would like to call the reader’s attention to the fact that unfortunately there were several references faultily assigned in Table 1. -
Fully validated simultaneous determination of bisoprolol fumarate and hydrochlorothiazide in their dosage forms using different voltammetric, chromatographic, and spectrophotometric analytical methods
Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Doğan Topal, Burcu; Uslu, Bengi; Özkan, Sibel Ayşıl (2013)Voltammetric, chromatographic, and spectrophotometric methods were developed for the simultaneous determination of bisoprolol fumarate (BIS) and hydrochlorothiazide (HCZ). Differential pulse and square wave voltammetry ... -
Fulvestrant-loaded polymer-based nanoparticles for local drug delivery: Preparation and in vitro characterization
Hasçiçek, Canan; Şengel Türk, Ceyda Tuba; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl; Bakar, Filiz; Daş Evcimen, Net; Savaşer, Ayhan; Özkan, Yalçın (Editions de Sante, 2017)The present investigation was aimed at optimizing Fulvestrant (FLV)-loaded nanoparticulate formulations to overcome side effects caused by the intramuscular injection of FLV, and to prolong local intratumoral action at ... -
Gemifloksasin'in Farmasötik Dozaj Şekillerinden Tayini için Basit, Duyarlı ve Güvenilir bir SK-FDD Yöntem
Gümüştaş, Mehmet; Özkan, Sibel A. (2012)Gemifloksasin mesilat'ın (GEM) miktar tayini için duyarlı, doğru, hızlı, tamamen valide edilmiş, güvenilir ve basit bir foto diyot dizi (FDD) dedektörlü sıvı kromatografi (SK) yöntemi geliştirilmiştir. Bu yöntemde GEM ve ... -
Investigation of voltammetric behavior and electroanalytical determination of anticancer epirubicin via glassy carbon electrode using differential pulse and square wave voltammetry techniques
Kurbanoğlu, Sevinç; Bozal Palabıyık, Burçin; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Editions de l'Academie Republique Populaire, 2015)The electrochemical oxidation of epirubicin was investigated using cyclic, differential pulse and square wave voltammetry at glassy carbon electrode. The aim of the study was to determine epirubicin levels in pharmaceuticals ... -
Modern Assay Techniques for Cancer Drugs: Electroanalytical and Liquid Chromatography Methods
Kurbanoğlu, Sevinç; Karadaş Bakırhan, Nurgül; Gümüştaş, Mehmet; Özkan, Sibel Ayşıl (Taylor and Francis Ltd., 2018)In the past decades, patients who have chemotherapy treatment have considerably increased number. At this point, the development of rapid precise, and reliable methods are very important to analyze cancer drugs from their ... -
Nanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic Techniques
Şengel Türk, Ceyda Tuba; Gümüştaş, Mehmet; Uslu, Bengi; Özkan, Sibel Ayşıl (Elsevier, 2017)Cancer is the primary leading cause of mortality in the world. The key of a successful cancer treatment depends on many important parameters, such as the application route, anticancer compound, and dosage form. Among the ... -
A novel core-shell-based chromatographic method supported by ratio derivative spectrophotometry for the simultaneous determination of perindopril, indapamide, and amlodipine ternary mixtures
Karadurmuş, Leyla; Gümüştaş, Mehmet; Kurbanoğlu, Sevinç; Uslu, Bengi; Özkan, Sibel Ayşıl (TUBİTAK, 2018)In this work, ratio spectra of the frst derivative spectrophotometric and liquid chromatographic methods have been described for the frst time for the simultaneous determination of perindopril (PER), indapamide (IND), and ... -
Optimization of stability indicating LC method for the sensitive in vitro determination from solid lipid nanoparticles and ex vivo analysis from rat skin of etofenamate
Gümüştaş, Mehmet; Şengel Türk, Ceyda Tuba; Badıllı, Ulya; Amasya, Gülin; Özkan, Sibel Ayşıl; Tarımcı, Nilüfer (Bentham Science Publishers B.V., 2017)Introduction: Etofenamate (2-(2-hydroxyethoxy) ethyl 2-[[3-(trifluoromethyl)phenyl]amino] benzoate) (ETO) is a yellowish viscous liquid which is a nonsteroidal anti-inflammatory drug (NSAID) that has been applied topically ... -
Selective and sensitive determination of repaglinide in pharmaceuticals by voltammetric and LC methods
Gümüştaş, Mehmet; Coşkun, Gökçe; Özkan, Sibel Ayşıl (Editions de l'Academie Republique Populaire, 2015)Detailed electrochemical study and novel voltammetric and LC methods are presented for the determination of repaglinide (RPG) in pharmaceuticals. Repaglinide in methanol: buffer solution (20:80; v/v) shows one or two anodic ... -
A sensitive and selective RP-LC method for the simultaneous determination of the antihypertensive drugs, enalapril, lercanidipine, nitrendipine and their validation
A RP-LC method is presented, which is sensitive and selective for the simultaneous determination of enalapril-lercanidipine and enalapril-nitrendipine binary mixtures in their pharmaceutical dosage forms. The analyte peaks ...
