Yazar "Nursal, Ayşe Feyda" için listeleme
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ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population
Öz, Tuba; Kaya, İsmail; Nursal, Ayşe Feyda; Aydın, Hasan Emre; Demir, Osman; Yiğit, Serbülent (2020)Aim: Intervertebral disc degeneration (IVDD) is caused by several genetic and environmental factors. Aggrecan is the major component of intervertebral disk matrix proteoglycan with multiple functional domains. The aim of ... -
Angiotensin converting enzyme gene insertion/deletion variant and familial Mediterranean fever-related amyloidosis
Nursal, Ayşe Feyda; Türkmen, Ercan; Uzun Kaya, Süheyla; Tekcan, Akın; Sezer, Özlem; Çelik, Sümeyya Deniz; Yiğit, Serbülent (Iranian Society of Nephrology, 2018)Introduction. The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin ... -
Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population
Pehlivan, Sacide; Çetinay, Pınar; Uysal, M. Atilla; Nursal, Ayşe Feyda; Kurnaz, Selin; Sever, Ulgen; Pehlivan, Mustafa (2020)Objective: Etiopathogenesis of schizophrenia (SCZ) involves several risk genes that induce inflammation, environmental stress factors and changes in the innate immune system. Patients with SCZ have the highest rate of ... -
Association of the TNF-α, IL-2, and IL-2RB gene variants with susceptibility to psoriasis in a Turkish cohort
Gülel, Aslıhan; İnaloz, Hüseyin Serhat; Nursal, Ayşe Feyda; Sever, Tuğçe; Pehlivan, Sacide (Termedia Publishing House Ltd., 2018)Aim of the study: The aim of this study was to investigate the role TNF-α, IL -2, and IL -2RB variants in psoriasis (Ps) and to evaluate the association between these variants and clinical features. Material and methods: ... -
Association of XRCC1 and XPD functional gene variants with nicotine dependence and/or schizophrenia: a case-control study and in silico analysis
Pehlivan, Sacide; Aydın, Nizamettin; Nursal, Ayşe Feyda; Uysal, Mehmet Atilla; Pehlivan, Mustafa; Tekcan, Akın; Yavuz, Fatih Kasım; Sever, Ülgen; Yavuzlar, Hazal; Kurnaz, Selin; Uysal, Seda; Çetinay Aydın, Pınar (Taylor and Francis Ltd., 2019)OBJECTIVE: The role of DNA repair mechanisms has received attention recently in schizophrenia (Sch). Sch patients show an increased prevalence of nicotine dependence (ND). This study aimed to find out whether functional ... -
C Deletion in Exon 4 Codon 63 of p53 Gene in Turkish Patients with Oral Squamous Cell Carcinoma
Tekcan, Akın; Gümüşay, Özge; Nursal, Ayşe Feyda; Yiğit, Serbülent; Yıldız, Serkan; Tümer, Mehmet Kemal (2020)OBJECTIVE Oral squamous cell carcinoma (OSCC) is the most frequently seen oral malignancy and accounts for up to 80-90% of all malignant neoplasms that occurin the oral cavity. The p53 tumor suppressor gene plays a crucial ... -
Correlation of HER2/TOP2A Gene Aberrations with RASSF1A/APC Gene Methylation Status in High-Risk Breast Cancer
Nursal, Ayşe Feyda; Çilingir, Oğuz; Eroğlu, Onur; Aras, Beyhan Durak; Çiftci, Evrim; Baydemir, Canan; Artan, Sevilhan (2020)OBJECTIVE Breast cancer (BC) is a heterogeneous malignancy and differs widely among different patients. The aim of this study was to investigate the relationship between the HER2/TOP2A gene aberrations and promoter methylation ... -
CYP2A6 gene variants may explain smoking status in a Turkish cohort
Pehlivan, Sacide; Uysal, Mehmet Atilla; Çağatay, Tülin; Nursal, Ayşe Feyda; Kekik Çınar, Çiğdem; Erkan, Feyza; Sever, Ülgen; Bingöl, Züleyha; Pehlivan, Mustafa; Pençe, Sadrettin (Taylor and Francis Ltd., 2018)OBJECTIVE: Nicotine is the main addictive agent present in tobacco and is principally metabolized by a cytochrome P450-mediated oxidation process. While smoking patterns differ widely among smokers, the metabolization rate ... -
Cytokine gene variants/expressions and non-syndromic microtia – Is there a link?
Nursal, Ayşe Feyda; Bekerecioğlu, Mehmet; Pehlivan, Sacide; Sever, Tuğçe; Büyükgüral, Berker (Continuing Education, and Scientific Research Association (CESRA), 2017)Sitokin gen varyantları/ekspresyonları ve non-sendromik mikrotia - Bir ilişki var mıdır?Amaç: Mikrotianın etyopatogenezinde birçok genetik ve çevreselfaktörler araştırılmasına rağmen hala belirsizlik vardır. Bu çalışmadabir ... -
Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population
Uysal, Mehmet Atilla; Sever, Ülgen; Nursal, Ayşe Feyda; Group, Yedikule Smoking Cessation Study; Pehlivan, Sacide (2019)Introduction: Dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. The purpose of this study is to investigate the relationship between the variable number ... -
Dopamine D4 Receptor Gene Exon III VNTR Variant influences smoking status in Turkish population
Uysal, Mehmet Atilla; Sever, Ülgen; Nursal, Ayşe Feyda; Yedikule Smoking Cessation Study Group; Pehlivan, Sacide (Turkish Neuropsychiatric Society, 2019)Introduction: Dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. The purpose of this study is to investigate the relationship between the variable number ... -
Effect of a functional variant of tumor necrosis factor-β gene in temporomandibular disorders: a pilot study
Yerliyurt, Kaan; Nursal, Ayşe Feyda; Tekcan, Akın; Karakuş, Nevin; Tümer, Mehmet Kemal; Yiğit, Serbülent (John Wiley and Sons Inc., 2019)Background: Temporomandibular disorders (TMD) are a group of conditions that cause chronic orofacial pain. The tumor necrosis factor ? (TNF-?) is a proinflammatory cytokine that is involved in the various aspects of the ... -
Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk
Pehlivan, Sacide; Çetinay Aydın, Pınar; Uysal, Mehmet Atilla; Şentürk Çiftçi, Hayriye; Sever, Ülgen; Yavuz, Fatih Kasım; Aydın, Nazan; Nursal, Ayşe Feyda (Universidade de Sao Paulo, 2019)Objectives Schizophrenia (Sch) is a severe and chronic mental illness. Smoking prevalence is higher in patients with Sch than general population. We aimed to investigate the effects of MAOB gene A644G variant on nicotine ... -
Effect of the IL-17F rs763780 Variant on Chronic Lymphocytic Leukemia and Multiple Myeloma Risk in a Turkish Cohort
Introduction: Chronic lymphocytic leukemia (CLL) is one of the most common leukemias in developed countries. Multiple myeloma (MM), a clonal plasma cell disease, is the second most prevalent hematological cancer. Interleukin-17 ... -
Endotelyal nitrik oksit sentaz (eNOS) ve miyeloperoksidaz (MPO) genlerin mikrotiyadaki rolü
Amaç: Bu çalışmanın amacı endotelyal nitrik oksit sentaz (eNOS) polimorfizmleriyle miyeloperoksidaz (MPO) genleri ve mikrotiya gelişimi arasındaki ilişkiyi belirlemekti. Yöntem:Çalışmaya akraba olmayan 19 (11 erkek, 8 ... -
The endothelial nitric oxide synthase gene variants as a risk factor for chronic lymphocytic leukemia
Pehlivan, Mustafa; Tomatır, Ayşe G.; Nursal, Ayşe Feyda; Şahin, Handan H.; Pehlivan, Sacide (Akademi Doktorlar Yayınevi, 2017)Nitric oxide (NO) plays complicated roles in carcinogenesis. Endothelial nitric oxide synthase (eNOS) gene is responsible for most of the NO produced. For this reason, it was considered that the eNOS gene variants is ... -
eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia
Pehlivan, Sacide; Uysal, Mehmet Ali; Aydın, Pelin C.; Pehlivan, Mustafa; Nursal, Ayşe Feyda; Yavuzlar, Hazal; Kurnaz, Serdar; Sever, Ülgen; Yavuz, Ferhat K.; Uysal, Sezer; Aydın, Nazan (Comenius University, 2017)BACKGROUND: This study aimed to evaluate whether VNTR variants in the Endothelial Nitric Oxide Synthase (eNOS) and the XRCC4 gene play any role in nicotine dependence (ND) and/or Schizophrenia+ND (Sch+ND) ethiopathogenesis. ... -
Genetic Variations of miRNAs and the Risk of Oral Squamous Cell Carcinoma: A Case-control Study
Aim: In this study, we investigated the association between two miRNA variants and the risk of oral squamous cell carcinoma (OSCC), and explored the interaction between clinical factors in the Turkish population. Methods: ... -
The IL-1Ra gene variable number tandem repeat variant is associated with susceptibility to temporomandibular disorders in Turkish population
Tümer, Mehmet Kemal; Nursal, Ayşe Feyda; Tekcan, Akın; Yerliyurt, Kaan; Geyko, Anastasia; Yiğit, Serbülent (John Wiley and Sons Inc., 2018)Background: Temporomandibular joint disorders (TMD) are a group of disorders involving temporomandibular joint and related structures. Interleukine-1 receptor antagonist (IL-1Ra) is an important anti-inflammatory molecule ... -
Il-1β and IL-1Ra variant profiles in Turkish patients with diabetic peripheral neuropathy
Nursal, Ayşe Feyda; İnanır, Ahmet; Rüstemoğlu, Aydın; Uzun, Süheyla; Şahin, Kübra; Yiğit, Serbülent (Bentham Science Publishers B.V., 2019)Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications of Type 2 diabetes mellitus (T2DM). This study was conducted to investigate the possible association between interleukin-1β (IL-1β) ...
