Yazar "Pehlivan, Sacide" için listeleme
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Association of Myeloperoxidase Gene Functional Variant with Schizophrenia and Smoking in a Turkish Population
Pehlivan, Sacide; Çetinay, Pınar; Uysal, M. Atilla; Nursal, Ayşe Feyda; Kurnaz, Selin; Sever, Ulgen; Pehlivan, Mustafa (2020)Objective: Etiopathogenesis of schizophrenia (SCZ) involves several risk genes that induce inflammation, environmental stress factors and changes in the innate immune system. Patients with SCZ have the highest rate of ... -
Association of the TNF-α, IL-2, and IL-2RB gene variants with susceptibility to psoriasis in a Turkish cohort
Gülel, Aslıhan; İnaloz, Hüseyin Serhat; Nursal, Ayşe Feyda; Sever, Tuğçe; Pehlivan, Sacide (Termedia Publishing House Ltd., 2018)Aim of the study: The aim of this study was to investigate the role TNF-α, IL -2, and IL -2RB variants in psoriasis (Ps) and to evaluate the association between these variants and clinical features. Material and methods: ... -
Association of XRCC1 and XPD functional gene variants with nicotine dependence and/or schizophrenia: a case-control study and in silico analysis
Pehlivan, Sacide; Aydın, Nizamettin; Nursal, Ayşe Feyda; Uysal, Mehmet Atilla; Pehlivan, Mustafa; Tekcan, Akın; Yavuz, Fatih Kasım; Sever, Ülgen; Yavuzlar, Hazal; Kurnaz, Selin; Uysal, Seda; Çetinay Aydın, Pınar (Taylor and Francis Ltd., 2019)OBJECTIVE: The role of DNA repair mechanisms has received attention recently in schizophrenia (Sch). Sch patients show an increased prevalence of nicotine dependence (ND). This study aimed to find out whether functional ... -
CNR2 rs2229579 and COMT Val158Met variants, but not CNR2 rs2501432, IL-17 rs763780 and UCP2 rs659366, contribute to susceptibility to substance use disorder in the Turkish population
Kurnaz, Selin; Yazici, Ahmet Bulent; Nursal, Ayse Feyda; Aydin, Pinar Cetinay; Atar, Ayca Ongel; Aydin, Nazan; Pehlivan, Sacide (Taylor & Francis Ltd, 2019)OBJECTIVE: Substance use disorders (SUD) are among the most important public health problems throughout the world. We investigated whether COMT (Val108/158Met), CNR2 (rs2501432 and rs2229579), UCP2 (rs659366), and IL-17 ... -
CYP2A6 gene variants may explain smoking status in a Turkish cohort
Pehlivan, Sacide; Uysal, Mehmet Atilla; Çağatay, Tülin; Nursal, Ayşe Feyda; Kekik Çınar, Çiğdem; Erkan, Feyza; Sever, Ülgen; Bingöl, Züleyha; Pehlivan, Mustafa; Pençe, Sadrettin (Taylor and Francis Ltd., 2018)OBJECTIVE: Nicotine is the main addictive agent present in tobacco and is principally metabolized by a cytochrome P450-mediated oxidation process. While smoking patterns differ widely among smokers, the metabolization rate ... -
Cytokine gene variants/expressions and non-syndromic microtia – Is there a link?
Nursal, Ayşe Feyda; Bekerecioğlu, Mehmet; Pehlivan, Sacide; Sever, Tuğçe; Büyükgüral, Berker (Continuing Education, and Scientific Research Association (CESRA), 2017)Sitokin gen varyantları/ekspresyonları ve non-sendromik mikrotia - Bir ilişki var mıdır?Amaç: Mikrotianın etyopatogenezinde birçok genetik ve çevreselfaktörler araştırılmasına rağmen hala belirsizlik vardır. Bu çalışmadabir ... -
Do UCP2, IL-17, mi196a2, and NR3C1 gene variants contribute to the risk of microtia? A preliminary study in Turkish population
Ozdilli, Kursat; Bekerecioglu, Mehmet; Nursal, Ayse Feyda; Pehlivan, Mustafa; Sever, Ulgen; Buyukgural, Berker; Pehlivan, Sacide (Elsevier Science Bv, 2018)[Abstract Not Available] -
Dopamine D4 Receptor Gene Exon III VNTR Variant Influences Smoking Status in Turkish Population
Uysal, Mehmet Atilla; Sever, Ülgen; Nursal, Ayşe Feyda; Group, Yedikule Smoking Cessation Study; Pehlivan, Sacide (2019)Introduction: Dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. The purpose of this study is to investigate the relationship between the variable number ... -
Dopamine D4 Receptor Gene Exon III VNTR Variant influences smoking status in Turkish population
Uysal, Mehmet Atilla; Sever, Ülgen; Nursal, Ayşe Feyda; Yedikule Smoking Cessation Study Group; Pehlivan, Sacide (Turkish Neuropsychiatric Society, 2019)Introduction: Dopaminergic gene variants may affect nicotine dependence through their possible impact on the dopamine reward pathway. The purpose of this study is to investigate the relationship between the variable number ... -
Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk
Pehlivan, Sacide; Çetinay Aydın, Pınar; Uysal, Mehmet Atilla; Şentürk Çiftçi, Hayriye; Sever, Ülgen; Yavuz, Fatih Kasım; Aydın, Nazan; Nursal, Ayşe Feyda (Universidade de Sao Paulo, 2019)Objectives Schizophrenia (Sch) is a severe and chronic mental illness. Smoking prevalence is higher in patients with Sch than general population. We aimed to investigate the effects of MAOB gene A644G variant on nicotine ... -
Effect of the IL-17F rs763780 Variant on Chronic Lymphocytic Leukemia and Multiple Myeloma Risk in a Turkish Cohort
Introduction: Chronic lymphocytic leukemia (CLL) is one of the most common leukemias in developed countries. Multiple myeloma (MM), a clonal plasma cell disease, is the second most prevalent hematological cancer. Interleukin-17 ... -
Endotelyal nitrik oksit sentaz (eNOS) ve miyeloperoksidaz (MPO) genlerin mikrotiyadaki rolü
Amaç: Bu çalışmanın amacı endotelyal nitrik oksit sentaz (eNOS) polimorfizmleriyle miyeloperoksidaz (MPO) genleri ve mikrotiya gelişimi arasındaki ilişkiyi belirlemekti. Yöntem:Çalışmaya akraba olmayan 19 (11 erkek, 8 ... -
The endothelial nitric oxide synthase gene variants as a risk factor for chronic lymphocytic leukemia
Pehlivan, Mustafa; Tomatır, Ayşe G.; Nursal, Ayşe Feyda; Şahin, Handan H.; Pehlivan, Sacide (Akademi Doktorlar Yayınevi, 2017)Nitric oxide (NO) plays complicated roles in carcinogenesis. Endothelial nitric oxide synthase (eNOS) gene is responsible for most of the NO produced. For this reason, it was considered that the eNOS gene variants is ... -
eNOS and XRCC4 VNTR variants contribute to formation of nicotine dependence and/or schizophrenia
Pehlivan, Sacide; Uysal, Mehmet Ali; Aydın, Pelin C.; Pehlivan, Mustafa; Nursal, Ayşe Feyda; Yavuzlar, Hazal; Kurnaz, Serdar; Sever, Ülgen; Yavuz, Ferhat K.; Uysal, Sezer; Aydın, Nazan (Comenius University, 2017)BACKGROUND: This study aimed to evaluate whether VNTR variants in the Endothelial Nitric Oxide Synthase (eNOS) and the XRCC4 gene play any role in nicotine dependence (ND) and/or Schizophrenia+ND (Sch+ND) ethiopathogenesis. ... -
Global and glucocorticoid receptor gene-specific (NR3C1) DNA methylation analysis in patients with cannabinoid or synthetic cannabinoid use disorder
Pehlivan, Sacide; Aytac, Hasan Mervan; Aydin, Pinar Cetinay; Nursal, Ayse Feyda; Pehlivan, Mustafa (Elsevier Ireland Ltd, 2021)This study investigates the relationship between cannabinoid use disorder (CUD) or synthetic cannabinoid use disorder (SCUD) and the global methylation, methylation of NR3C1 gene promotor, and NR3C1 BclI poly-morphism, ... -
Impact of UCP2 -866G/A Variant on Smoking Risk
Objective: Mitochondria are multifunctional and dynamic organelles found in cells. Nicotine is a natural alkaloid found in the tobacco plant and has been well studied as a component of cigarette smoke. It has also been ... -
Interleukin-1 gene variants and the risk of non-syndromic microtia
Nursal, Ayşe Feyda; Bekerecioğlu, Mehmet; Büyükgüral, Berker; Pehlivan, Sacide (Pamukkale Üniversitesi, 2018)Purpose: Microtia is a congenital anomaly, manifested by a small and disfigured auricle. Interleukin (IL) 1 is an important mediator of inflammation and cartilage destruction, This study is aimed at investigating association ... -
Investigating the eNOS and IFN-gamma Gene Variants Susceptible to Bipolar Disorder or Schizophrenia in a Turkish Cohort
Pehlivan, Sacide; Aytac, Hasan Mervan; Ciftci, Hayriye Senturk; Oyaci, Yasemin; Pehlivan, Mustafa; Nursal, Ayse Feyda (Turkish Assoc Psychopharmacology, 2020)Background: Schizophrenia (Sch) and bipolar disorder (BD) are debilitating chronic psychiatric disorders that are both etiologically and clinically heterogeneous. According to the gathered evidence, multiple mental disorders ... -
Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?
Pehlivan, Sacide; Akaltun, Mazlum Serdar; Pehlivan, Mustafa; Gürsoy, Savaş; Nursal, Ayşe Feyda (2020)Aim: Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association ... -
Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?
Pehlivan, Sacide; Inaloz, Huseyin Serhat; Nursal, Ayse Feyda; Gulel, Aslihan; Pehlivan, Mustafa (Aves, 2018)Introduction: Psoriasis (Ps) is a chronic, immune-mediated inflammatory skin disorder with an incompletely understood etiology. The aim of this study was to investigate the relationship between the suspectibility to Ps and ...
