Synthesis and characterization of 1,3,4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities
Mohammad Emsaed, Hamza Ahmet
Özkan, Osman Emre
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CitationMuğlu, H., Şener, N., Emsaed, H. A. M., Özkınalı, S., Özkan, O. E., & Gür, M. (2018). Synthesis and characterization of 1, 3, 4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities. Journal of Molecular Structure, 1174, 151-159.
New 1,3,4-thiadiazole compounds were synthesized through the cyclization reaction of 4-phenoxybutyric acid and N-phenylthiosemicarbazide derivatives with phosphorous oxychloride. The structures of 1,3,4-thiadiazole compounds (I–XII) were clarified using spectroscopic methods such as FT-IR, 1H NMR, and 13C NMR. Moreover, their antibacterial activities were tested against gram negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, Escherichia coli) and gram positive bacteria (Staphylococcus aureus, Bacillus subtilis, Enterococcus durans) using a disk diffusion method. An antifungal activity experiment was further carried out against Candida albicans using the disk diffusion method. While these compounds presented antibacterial activity against S. aureus, they did not show antimicrobial activity against gram negative (E. coli, E. aerogenes, S. kentucky, S. enteritidis, S. typhimurium, S. infantis) and gram positive (B. subtilis) bacteria, and the fungi C. albicans. © 2018 Elsevier B.V.