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dc.contributor.authorMuğlu, Halit
dc.contributor.authorŞener, Nesrin
dc.contributor.authorMohammad Emsaed, Hamza Ahmet
dc.contributor.authorÖzkınalı, Sevil
dc.contributor.authorÖzkan, Osman Emre
dc.contributor.authorGür, Mahmut
dc.identifier.citationMuğlu, H., Şener, N., Emsaed, H. A. M., Özkınalı, S., Özkan, O. E., & Gür, M. (2018). Synthesis and characterization of 1, 3, 4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities. Journal of Molecular Structure, 1174, 151-159.en_US
dc.description.abstractNew 1,3,4-thiadiazole compounds were synthesized through the cyclization reaction of 4-phenoxybutyric acid and N-phenylthiosemicarbazide derivatives with phosphorous oxychloride. The structures of 1,3,4-thiadiazole compounds (I–XII) were clarified using spectroscopic methods such as FT-IR, 1H NMR, and 13C NMR. Moreover, their antibacterial activities were tested against gram negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, Escherichia coli) and gram positive bacteria (Staphylococcus aureus, Bacillus subtilis, Enterococcus durans) using a disk diffusion method. An antifungal activity experiment was further carried out against Candida albicans using the disk diffusion method. While these compounds presented antibacterial activity against S. aureus, they did not show antimicrobial activity against gram negative (E. coli, E. aerogenes, S. kentucky, S. enteritidis, S. typhimurium, S. infantis) and gram positive (B. subtilis) bacteria, and the fungi C. albicans. © 2018 Elsevier B.V.en_US
dc.publisherElsevier B.V.en_US
dc.subjectAntimicrobial Activityen_US
dc.subjectIR and NMR Spectroscopiesen_US
dc.titleSynthesis and characterization of 1,3,4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activitiesen_US
dc.relation.journalJournal of Molecular Structureen_US
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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