Hitit Üniversitesi Kurumsal Akademik Arşivi
DSpace@Hitit, Hitit Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Real-world outcomes and prognostic factors in primary mediastinal B-cell lymphoma: a multicenter study of 157 patients
(SPRINGER, 2025) Küçükyurt, S; Koca, O; Demirsoy, ET; Akın, S; Doğan, A; Gören, D; Yiğitbaşı, A; Şahin, O; İpek, Y; Çiftçiler, R; Şahin, F; Mengüç, MU; Özünal, İE; Kösemehmetoğlu, ÖS; Özgür, Y; Atalay, F; Öztürk, HBA; Yüksel, M; Kanat, NT; Uysal, A; İltar, U; Yıldız, A; Karadağ, FK; Baysal, M; Uğur, MC; Güven, S; Pınar, İE; Mehtap, Ö; Barista, İ; Demir, AM; Yeral, M; Selim, C; Saydam, G; Atagündüz, İK; Tiğlioğlu, P; Dilek, İ; Ayer, M; Güneş, AK; Yüksel, MK; Ünal, A; Salim, O; Soyer, N; Ateşoğlu, EB; Eskazan, AE
Primary mediastinal B-cell lymphoma (PMBCL) is a rare and distinct subtype of non-Hodgkin lymphoma. No consensus exists on optimal frontline treatment, and the use of R-CHOP +/- radiotherapy (RT) and DA-EPOCH-R +/- RT remains common, yet comparative real-world data are limited. In our multicenter retrospective study, we analyzed PMBCL patients, stratified by the first-line therapy (R-CHOP-21 +/- RT or DA-EPOCH-R +/- RT). Primary outcomes were complete response (CR) rate, progression-free survival (PFS), and overall survival (OS), alongside assessment of treatment-related toxicities and prognostic factors for PFS and OS. We included 157 patients [R-CHOP +/- RT group (n = 80) and DA-EPOCH-R +/- RT group (n = 77)] with a median age of 31 years, of whom 68.2% were female. CR rates were similar for R-CHOP +/- RT (75%) and DA-EPOCH-R +/- RT (76.6%). RT use was higher in the R-CHOP group (41.2% vs. 19.5%, p = 0.002). DA-EPOCH-R had significantly higher toxicity (29.9% vs. 16.2%, p = 0.033). The median follow-up of the entire cohort was 29 months with 2-year PFS and OS rates of 73.9% and 83.6%, respectively. Also, PFS and OS did not differ between regimens. In patients achieving CR with R-CHOP, RT omission did not impact survival. Multivariate analysis identified older age, poor performance status, superior vena cava syndrome and splenic involvement as independent OS predictors, while pericardial effusion, splenic involvement and hemoglobin < 10.5 g/dL were linked to inferior PFS. R-CHOP-21 +/- RT and DA-EPOCH-R +/- RT provide comparable efficacy in PMBCL. Due to the higher toxicity of DA-EPOCH-R, for those achieving CR following R-CHOP, selective RT omission may be a reasonable alternative. Established and disease-specific prognostic factors should guide individualized treatment strategies.
Impact of the COVID-19 Pandemic on CLABSI Rates and Antibiotic Resistance: A Multicenter Study in Türkiye
(DOC DESIGN INFORMATICS CO LTD, 2025) Sargın-Altınok, E; Keske, S; Batırel, A; Bilgin, H; Gülten, E; Menekşe, S; Gölbol, A; Konya, P; Altunal, LN; Özer, D; Asan, A; Deniz-Yüksel, A; Akdoğan, Ö; Yanık-Yalçın, T; Akgül, F; Aliravcı, İD; Karagöz, T; Şahin, A; Erdem, İ; Gürbüz, E; Yekta-Ürkmez, F; Karakoç, ZÇ; Kaçmaz, B; Eren-Korkmaz, Ö; Karslıoğlu, M; Arslan, M; Toygar-Deniz, M; Aydın, M; Demirtürk, N; Azap, A; Ergönül, Ö
Objective: The COVID-19 pandemic significantly disrupted infection control practices in healthcare settings. Previous studies have reported increased rates of central line-associated bloodstream infections (CLABSI), particularly during the early stages and peak periods of the pandemic. This multicenter study aimed to evaluate the impact of the COVID-19 pandemic on CLABSI rates in T & uuml;rkiye over a four-year period from 2019 to 2022. Materials and Methods: We conducted a retrospective analysis of prospectively collected CLABSI data from hospitals across various regions of T & uuml;rkiye between 2019 and 2022. The study period was divided into three phases: pre-pandemic, early pandemic, and late pandemic. Demographic and clinical characteristics, mortality rates, and microbiological data were analyzed. Pathogen distribution and antibiotic resistance patterns were compared between the pre-pandemic and pandemic periods. Results: A total of 25 hospitals participated in the study. The CLABSI rates per 1000 catheter days were 4.26 in 2019, 4.13 in 2020, 3.68 in 2021, and 3.53 in 2022. Across all periods, 3238 pathogens were identified. Gram-negative bacteria predominated both before and during the pandemic, with Acinetobacter baumannii (18.6%) and Klebsiella pneumoniae (17.8%) being the most common. Notably, an increase in carbapenem and colistin resistance in K. pneumonia was observed during the pandemic compared to the pre-pandemic period. Conclusions: In T & uuml;rkiye, the predominant causative agents of CLABSI did not change during the pandemic, with Klebsiella spp. and A. baumannii being most frequently isolated. However, the rise in CLABSI-associated mortality during the pandemic highlights the broader impact of healthcare system disruptions.
Methodological Considerations in Blood Pressure Variability Assessment for Branch Atheromatous Disease
(WILEY, 2025) Aker, Mücahit; Kalçık, Macit; Bekar, Lütfü
Dear Editor,
The recent multicenter study examining the relationship between systolic blood pressure variability (BPV) and 90-day functional outcomes in branch atheromatous disease (BAD) provides valuable data on a clinically challenging stroke subtype [1].
Renal Function and Atrial Remodeling: Interpreting Voltage-Mapping Limitations
(WILEY, 2025) Aker, Mücahit; Kalçık, Macit; Bekar, Lütfü
To the Editor,
We read with interest the recent article by Deng et al., hichexplored the association between renal function and left atriallow-voltage area (LVA) burden in patients with atrial fibrillation(Deng et al. 2025).
Critical Appraisal of Circadian Blood Pressure Patterns as Predictors of Mortality in the Intensive Care Setting
(WILEY, 2025) Kalçık, Macit; Bayam, Emrah
To the Editor,
We have recently, with great interest, read the recent article byZhao et al., “Association of 24-h Blood Pressure Pattern withMortality in ICU Patients: A Retrospective Cohort Study” [1].
