Yazar "Akbay, Serap" seçeneğine göre listele
Listeleniyor 1 - 5 / 5
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model(Springer Verlag, 2016) Öz, Murat; Çetinkaya, Nilüfer; Baş, Sevda; Korkmaz, Elmas; Özgü, Emre; Terzioğlu, Serdar Gökay; Büyükkağnıcı, Ümran; Akbay, Serap; Çaydere, Muzaffer; Güngör, TayfunPurpose: Platelet-rich plasma (PRP) has been known to possess an efficacy in tissue regeneration. The aim of this study was to determine the role of PRP on post-operative adhesion formation in an experimental rat study. Methods: Thirty Sprague-Dawley rats were randomly divided into control, hyaluronic acid, and PRP treatment groups and operated on for uterine horn adhesion modeling. Blood was collected to produce a PRP with platelet counts of 688 × 10 3 /?L, and 1 ml of either hyaluronic acid gel or PRP was administered over the standard lesions, while the control group received no medication. The evaluation of post-operative adhesions was done on the 30th post-operative day. The location, extent, type, and tenacity of adhesions as well as total adhesion scores, tissue inflammation, fibrosis and transforming growth factor-1beta (TGF-1?) expressions were evaluated. Results: The total adhesion score was significantly lower in the PRP group (3.2 ± 1.5) compared with the hyaluronic acid (5.0 ± 1.3) and control (8.1 ± 1.7) groups. The extent of the adhesions was significantly lower in the PRP group. There was no significant difference in the type and tenacity of adhesions between the hyaluronic acid and the PRP group. The level of inflammation was significantly higher in the control group than the others, while there was no difference between the PRP and hyaluronic acid groups. TGF-1? expression was significantly lesser in the PRP group than the control and hyaluronic acid groups. Conclusions: PRP is more effective than hyaluronic acid treatment in preventing post-operative adhesion formation in an experimental rat uterine horn adhesion model. © 2016, Springer-Verlag Berlin Heidelberg.Öğe Iatrogenic implantation of placental Tissue after first trimester dilatation and curettage presenting as a uterine mass: A report of two cases(Taylor and Francis Ltd, 2017) Topfedaisi Özkan, Nazlı; Sarı, Mustafa Erkan; Görkem, Ümit; Bayramoğlu, Hatice; Akbay, Serap; Meydanlı, Mehmet Mutlu; Güngör, TayfunUterine perforation after first trimester dilatation and curettage is a rare complication (Kaali et al. 1989; Chen et al. 1995). Large defects in the uterine wall or injury to other intra-abdominal organs can result in serious problems and require immediate surgical treatment (Augustin et al. 2013; Counghlin et al. 2013). Small perforations usually resolve on their own without any complications. The implantation and growth of trophoblastic tissue along the perforation site is a very rare entity (Lam et al. 2002; Pascual et al. 2003). This situation can be confused with benign or malignant processes. We describe two cases that were diagnosed with retained trophoblastic tissue in the myometrium after first-trimester dilatation and curettage.Öğe Is mucinous adenocarcinoma of the endometrium a risk factor for lymph node involvement? A multicenter case–control study(Springer Tokyo, 2015) Güngördük, Kemal; Özdemir, Aykut; Ertaş, İbrahim Egemen; Selçuk, İlker; Solmaz, Ulaş; Özgü, Emre; Mat, Emre; Gökçü, Mehmet; Karadeniz, Tuba; Akbay, Serap; Sancı, Muzaffer; Meydanlı, Mehmet Mutlu; Ayaz, Duygu; Güngör, TayfunPurpose: The purpose of this multicenter case–control study was to compare the demographic and clinical characteristics of patients with mucinous adenocarcinoma of the endometrium (MAE) and endometrioid endometrial carcinoma (EEC). Methods: A retrospective review of two cancer registry databases in Turkey was conducted to identify patients diagnosed with MAE between January 1996 and December 2012. Each patient was matched with a control EEC patient by age and tumor grade. Cases and controls were compared in terms of known risk factors for lymph node metastasis, disease-free survival (DFS), and overall survival (OS). Results: The analysis included 112 patients with MAE and 112 with EEC. No significant difference in baseline characteristics was evident between the two groups. Lymphovascular space invasion, deep myometrial invasion, cervical involvement, and tumor diameter did not differ significantly between the mucinous and endometrioid cases. Multivariate analysis confirmed that only mucinous histology (OR 2.2, 95 % CI 1.1–4.5; P = 0.02) was an independent predictor of lymph node involvement. Although the median DFS and OS tended to be better in the endometrioid group, the differences were not statistically significant. Routine appendectomy was performed in 52 (46.2 %) patients with MAE. No mucinous tumor of the appendix was identified. Conclusion: Routine appendectomy is not necessary when the appendix is grossly normal at the time of surgery for MAE. Although the DFS and OS of EEC and MAE patients were similar, the risk of nodal metastasis in MAE patients was greater than that in ECC patients, and we thus suggest to perform retroperitoneal lymphadenectomy (both pelvic and para-aortic) for patients with MAE during the initial operation. © 2014, Japan Society of Clinical Oncology.Öğe Response to the Letter to the Editor—Re: A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model(Springer Verlag, 2016) Öz, Murat; Çetinkaya, Nilüfer; Baş, Sevda; Korkmaz, Elmas; Özgü, Emre; Terzioğlu, Serdar Gökay; Büyükkağnıcı, Ümran; Akbay, Serap; Çaydere, Muzaffer; Güngör, TayfunThank you for your interest in our experimental study entitled “A randomized controlled experimental study of the efficacy of platelet-rich plasma and hyaluronic acid for the prevention of adhesion formation in a rat uterine horn model” [1]. We read your comments on the article with great interest.Öğe Which Patients Need Staging Surgery For Steroid Cell Tumors, Nos?(Lippincott Williams & Wilkins, 2015) Selçuk, İlker; Akbay, Serap; Öz, Murat; Meydanlı, Mehmet Mutlu; Güngör, Tayfun[Abstract Not Available]
