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    Synthesis, characterization, and antimicrobial properties of a new ligand and its Pd(II), Ru(II), Fe(II), Co(II) complexes
    (Düzce Üniversitesi, 2018) Buldurun, Kenan; Turan, Nevin; Alan, Yusuf; Çolak, Naki
    Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, antiviral, and antipyretic properties. In this study, the complexes of (E)-2-(3,5-di-tert-butyl-2-hydroxybenzylideneamino)-6-methyl4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (L) with Co(II), Fe(II), Pd(II) and Ru(II) were successfully prepared. Structures of Schiff base and its metal complexes obtained were confirmed by FT-IR, 1H-NMR, 13CNMR, UV–vis, magnetic susceptibility, mass spectroscopy and elemental analysis. Antimicrobial activity of the synthesized Schiff base and its metal complexes have been studied. When the antimicrobial activities of the compounds were examined, it was observed that the lowest activity was exhibited by the ligand, and the highest activity was exhibited by the Co(II) and Pd(II) complexes. None of our compounds were been found to exhibit antifungal activity.
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    Öğe
    Synthesis, characterization, antioxidant, antimicrobial and DNA binding properties of ruthenium(II), cobalt(II) and nickel(II) complexes of Schiff base containing o-vanillin
    (Springer Netherlands, 2019) Turan, Nevin; Buldurun, Kenan; Alan, Yusuf; Savcı, Ahmet; Çolak, Naki; Mantarcı, Asım
    In this study, the complex combinations of Ru(II), Co(II) and Ni(II) with Schiff base obtained through the condensation of (E)-methyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate with 2-hydroxy-3-methoxybenzaldehyde (o-vanillin) were prepared. The characterization of newly developed complexes was implemented by IR, elemental analyses, magnetic susceptibility, mass spectra, UV–Vis and thermogravimetry/differential thermal analysis. The X-ray powder diffraction pattern of the complexes was also investigated. The geometries of the complexes were found to be octahedral. Furthermore, antioxidant, antimicrobial and pBR322 plasmid DNA cleavage activities were investigated. The antibacterial effects of the Co(II) complex on Gram-positive and Gram-negative bacteria were identified to be higher than those of ligand. The Ru(II) complex was found to have higher radical scavenging potential on 1,1-diphenyl-2-picryl-hydrazyl (DPPH·), superoxide anion (O 2 ? ), hydroxyl (OH) and 2,2?-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radicals, in comparison with ligand. The binding affinity of the Ni(II) complex was higher than that of ligand. © 2019, Springer Nature B.V.