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  • Küçük Resim
    Öğe
    DNA binding and cleavage activities of Na[B(Glu)(OH)2] ·2H2O, Na[B(Cit)(OH)2]·2H2O, Li[B(Sal)(OH)2], and Mg[B(Sal)(OH)2]·2H 2O complexes
    (2013) Arslantaş, Ali; Devrim, Alparslan Kadir; Sudağıdan, Mert; Köse, Dursun Ali
    The interaction of some previously reported complexes Na[B(Glu)(OH) 2]·2H2O, Na[B(Cit)(OH)2]·2H 2O, Li[B(Sal)(OH)2], and Mg[B(Sal)(OH)2] ·2H2O with cattle genomic DNA (CG-DNA) was investigated using UV absorption, viscosity measurements, and fluorescence studies. These complexes interact with DNA through the intercalative mode of binding. In addition, the DNA cleavage activity of the complexes in presence of H2O2 was determined using agarose gel electrophoresis. All complexes exhibit moderate ability of cleavage to the DNA. © 2013 A. Arslantas et al.
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    Öğe
    Investigation of dna binding and cleavage activities of boron complexes in the presence of hydrogen peroxide
    (Universitatea Babes-Bolyai, Catedra de Filosofie Sistematica, 2014) Devrim, Alparslan Kadir; Arslantaş, Ali; Sudağıdan, Mert; Köse, Dursun Ali; Zümreoğlu Karan, Birgül
    Magnesium [di(hydroxy)mono(citratoborate)]dihydrate (Mg[B(Cit)(OH)2]2.2H2O), Lithium [di(hydroxy)mono(citratoborate)]hydrate Li[B(Cit)(OH)2].H2O, Sodium [di(hydroxy)mono(salicylato) borate)hydrate Na[B(Sal)(OH)2].H2O and Magnesium[bis(salicylatoborate)]decahydrate Mg[B(Sal)2]2.10H2O) complexes have been synthesized and characterized. The cattle genomic DNA (CG-DNA) interaction of the complexes was studied by spectroscopic methods, viscosity, and electrophoresis measurements. The complexes partially intercalated to CG-DNA. Furthermore, DNA cleavage activity of these complexes was also investigated using agarose gel electrophoresis and the complexes show moderate ability of cleavage to the DNA