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Öğe Comparison of Preoperative and Postoperative Antioxidant Levels in Patients with Adenotonsillar Hypertrophy(2020) Ekinci, Adnan; Dağıstan, Hakan; Aksoy, Ahmet; Ekinci, HalilObjective: This study aimed to compare the serum oxidative stress levels of patients with adenotonsillar hypertrophy (ATH) with those of controls and to investigate the effects of adenotonsillectomy on the oxidative stress levels. Material and Methods: Thirty healthy children (mean age, 6 years) and 30 patients with ATH (mean age, 7 years) aged 2-12 years were included in the study. Serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON) levels were compared between the patient and control groups. The preoperative and postoperative levels were also compared within the patient group. Results: The TOS and OSI levels were significantly higher in the patient group than in the control group (p=0.007 and p=0.027, respectively). There was no significant difference between the patient and control groups in terms of the TAS and PON levels (p=0.399 and p=0.237, respectively). The TOS and OSI levels in the patient group were significantly higher in the preoperative than in the postoperative period (p=0.005 and p=0.023, respectively), whereas there were no significant differences in the TAS and PON levels between the preoperative and postoperative period (p=0.192 and p=0.262, respectively). Conclusion: These findings demonstrate that patients with ATH are exposed to high levels of oxidative stress and that adenotonsillectomy normalizes the oxidative stress.Öğe Destructive fibrosarcoma of the maxillary sinus(2018) Ekinci, Adnan; Karataş, Duran; Yetiş, Abdurrahman; Erenler, Behice Hande; Özcan, MügeParanasal fibrosarcoma of nasal cavity and paranasal sinuses is a very rare malignant tumor. It is usually presented with nasal obstruction and epistaxis. In this clinical report, clinical symptoms, pathogenesis, and treatment principles of a paranasal fibrosarcoma originating from the right maxillary sinus and obstructing the right nasal passage are discussed.A 55-year-old male patient was admitted to the authors clinic with complaints of nasal obstruction and epistaxis lasting for 2 years. Anterior rhinoscopy revealed a mass lesion which obstructed the right nasal passage and caused frequent epistaxis. An opacity consistent with soft tissue lesion which was originated from the right maxillary sinus and filled the right nasal passage was observed in paranasal tomography. Magnetic resonance imaging revealed that the mass lesion was contrasted. Tumor was seen to erode orbital floor, and lateral and anterior walls of the maxillary sinus. Biopsy result was reported as papilloma. The patient was treated with Denker approach as anterior wall of the maxillary sinus was eroded by the tumor lesion and the mass lesion was excised. The patient received postoperative radiotherapy as pathological diagnosis was reported as paranasal fibrosarcoma.Öğe Effects of Nimodipine and Nigella sativa on Oxidative Stress and Apoptosis in Serum and Brain Tissue of Rats with Experimental Head Trauma(Turkish Neurosurgical Soc, 2021) Kamaşak, Kağan; Başarslan, Kağan; Dağlı, Ahmet Turan; Öğden, Mustafa; Alabalık, Ulaş; Ekinci, Adnan; Ceviz, AdnanAIM: To investigate whether Nimodipine (N) and Nigella sativa (NS) oil have protective, antioxidant effects in brain injury caused by experimental head trauma. MATERIAL and METHODS: Fifty albino Wistar rats were randomly divided into 5 groups that underwent experimental head trauma. Oxidative parameters were compared in the serum and brain tissue of the different groups. In addition, apoptosis and caspase-3 immunoreactivity were evaluated by histopathological examination. RESULTS: Serum total antioxidant status (TAS) levels were significantly increased in N and N+NS groups when compared with controls (p=0.001, p<0.01). Tissue TAS levels were significantly higher in the NS and N+NS groups compared to controls (p=0.001, p<0.01). Total oxidant status levels in the brain tissue were significantly higher in the NS group than in the control group (p=0.021). CONCLUSION: N and NS were shown to significantly reduce the occurrence of oxidative stress in secondary brain injury due to head trauma. We also found that apoptosis levels decreased in response to N, NS and N+NS treatments after head trauma.Öğe Evaluation of auditory and cochlear functions in ankylosing spondylitis patients according to the site of involvement(Springer Verlag, 2017) Karataş, Duran; Doğan, İbrahim; Ekinci, Adnan; Yetiş, Abdurrahman; Özcan, MügeAnkylosing spondylitis (AS) is a chronic systemic inflammatory disease of unknown origin with a prevalence rate about 1% in the population. Audiovestibular dysfunction is encountered in AS and sensorineural hearing loss is the most common form. The present study aimed to evaluate auditory and cochlear function in AS patients according to the site of involvement. A total of 47 patients followed for AS in the rheumatology outpatient clinic and 30 healthy controls were enrolled in the study. Subgroups of AS were identified according to the site of involvement. The participants underwent complete otolaryngological examination together with audiometry, otoacoustic emission and tympanometry tests. Disease Activity Index (BASDAI) was determined in the AS group. Hearing loss was detected in seven patients (15%) in the AS group and in four subjects (8%) in the control group. There was statistically significant difference between the patient and control groups in terms of mean bone conduction hearing level at 4000 hertz (Hz) in the right and left ears (p = 0.028, p = 0.049). There was no significant difference between the subgroups of AS in terms of overall auditory and cochlear functions. No correlation was determined between auditory values and Disease Activity Index and CRP (p > 0.05 for all). Our results reveal that AS has minimal effect on auditory and cochlear functions. The effects of subgroups of AS on auditory functions were comparable. The authors concluded that BASDAI and CRP are not convenient in monitoring auditory functions of AS patients. © 2017, Springer-Verlag GmbH Germany.Öğe Evaluation of serum prolidase enzyme activity and oxidative stress in patients with tinnitus(Elsevier Editora Ltda, 2019) Ekinci, Adnan; Kamaşak, KağanIntroduction: Tinnitus is defined as the perception of sound in the head or in the head in the absence of external sounds. The cause of tinnitus is still unknown. Objective: We aimed to compare the serum levels of total oxidant status, total antioxidant status, serum prolidase enzyme activity and the oxidative stress index in patients with tinnitus to those of normal subjects. Methods: Twenty five patients with tinnitus (mean age 34.3) and 25 healthy controls (mean age 37.2) were included in the study. Results: Total oxidant status levels in the patient group were significantly higher than in the control group (p = 0.037). The mean total oxidant status value was 2.54 ± 0.95 mmoL/L in the patient group, and 2.06 ± 0.98 mmoL/L in the control group. The mean oxidative stress index level was 0.22 ± 0.10 AU in the patient group, while it was 0.17 ± 0.08 AU in the control group. Oxidative stress index was significantly higher in the patient group (0.026). There was no significant difference between the groups in terms of total antioxidant status values (p = 0.838). The mean serum prolidase enzyme activity level was 202.74 ± 33.56 U/L in the patient group and 175.46 ± 42.68 U/L in the control group. Serum prolidase enzyme activity levels in the patient group were significantly higher than in the control group (0.040). Conclusion: We detected that the total oxidant status, oxidative stress index and serum prolidase enzyme activity levels were higher in patients with tinnitus when compared to the healthy controls. This finding suggests that oxidative stress index and serum prolidase enzyme activity may play a role in the etiopathogenesis of tinnitus. © 2019Öğe İnverted Papillomlu Olgularda Klinik Tanı Ve Tedavi Yaklaşımımız(2018) Ekinci, Adnan; Özcan, MügeAmaç: Bu çalışmanın amacı kliniğimizde burun ve paranazal sinüslerin inverted papillomaları tanısı ile cerrahi uygulanan olguların tedavi sonuçlarını değerlendirmektir. Gereç ve yöntem: Ocak 2015-Nisan 2017 tarihleri arasında burun ve paranazal sinüs inverted papilloma tanısı almış yedi hasta retrospektif olarak incelendi. Hastaların yaşı, cinsiyeti, tümörün çıkış aldığı nokta ve yayılım bölgeleri incelendi. İP tanısı alan hastaların bilgisayarlı tomografi, manyetik rezonans görüntüleme bulguları, cerrahi tedavi yöntemi, histopatolojik tanı ve takibi sunuldu. Bulgular: Hastalar 41 ile 68 yaş arasında ve hepsi erkek idi (ortalama yaş 56,14 olarak bulundu). Olguların polikliniğe en sık başvuru nedeni sırası ile tek taraflı burun tıkanıklığı %100 (7/7), burun akıntısı %71 (5/7) ve baş ağrısı %57 (4/7) idi. Üç hastada tek taraflı sağ nazal kavitede tulumum var iken, dört olguda ise sol nazal kavite tutulumu vardı. Hiçbir olgumuzda bilateral tutulum gözlenmedi. İnverted papillomun en sık orta konka %42 (4/7), maksiler sinüs %42 (4/7) ve nazal septum %14 (1/7) kaynaklı olduğu gözlendi. Sonuç: Bu çalışmada inverted papillomlu olguların hepsi ileri yaş grubundaki erkek hastalardı ve tek taraflı tutulum vardı. Olguların %71,42’sine (5/7) endoskopik yaklaşımla tümörün çıkarılması ve %28,18’ine (2/7) ise endoskopik tedaviyle birlikte Caldwell-Luc operasyonu yapıldı. Olguların takip süresi ortalama 15 ay idi. Olguların hiçbirinde takip döneminde nüks gözlenmedi.Öğe Investigation of serum oxidative stress levels in patients with nasal polyps(Dicle Üniversitesi Tıp Fakültesi, 2018) Ekinci, AdnanObjective: To compare serum total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) levels between nasal polyp patients and heal thy subjects. Method: In the present study, The nasal polyp group includes 26 males an 22 females, a total of 48 patients (mean age 37.11±12.07 years), while the control group included 22 males and 24 females, a total of 46 healthy subjects (mean age 36.91±13.03) years. Groups were compared in terms of serum TAS, TOS and PON1 levels. Results: The mean TAS level was 1.248 mmol/L in the control group, it was 1.176 mmol/L in the patient group (p=0.044). The mean TOS level was 3.443 mmol/L in the control group, and it was 6.720 mmol/L in the patient group (p=006). Nasal polyp and control groups did not show any significant difference for PON1 (301.15 U/L vs. 295.75 U/L,p>0.05). Conclusion: Serum TOS levels were significantly higher, and TAS levels were significantly lower in patients with nasal polyposis compared it the control group. There was no significant difference between the patients with nasal polypand the control group in terms of the PON1 values.Öğe Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats(Elsevier Ireland Ltd, 2018) Ekinci, Adnan; Koç, Sema; Erdoğan, Ahmet Serhat; Kesici, HakanObjectives: We aimed to investigate the prophylactic effect simvastatin of and mitomycin C (MMC) on laryngeal and tracheal stenosis in tracheotomised rats by histopathological evaluation of laryngotracheal segment. Randomized prospective single-blind. Material and method: Standard vertical tracheotomy was performed on 24 rats. Then the animals were randomly divided into three groups as A, B and C. In group A 0.4 mg/day once daily mitomycin C was injected to the paratracheal region for 14 days. In group B daily 30 mg/kg/day simvastatin was given via gavage to rats for 14 days. In group C 2 cc/day intraperitoneal saline given to rats and the created control group by 14 days follow up. After 10 days, tracheal cannulas were removed. Three weeks later, all animals were euthanized and trachea specimens were harvested. The present study investigates the effects of MMC and Simvastatin on fibrosis, inflammation, stenosis index and tracheal wall thickness in a tracheal injury model. Results: The difference between the groups in terms of degree of inflammation scores was statistically insignificant (P = 0,187). Differences between the groups were found to be insignificant in terms of the preventionof fibrosis (P = 0,993). There was no significant difference between groups in terms of stenosis index (P = 0.645). In terms of wall thickness, control, simvastatin and mitomycin C groups were statistically different (p = 0.038). The difference between post-hoc test results was between Mitomycin C and control groups (p = 0.036). Maximum wall thickness in the MMC group (0,299 mm) was significantly lower compared to the control group (0,382 mm)(P < 0,0001). Maximum wall thickness was statistically lower in the simvastatin (0.324 mm) group compared with the control group (0.382 mm) (P < 0.0001). There was no statistically significant difference between the simvastatin group (0,198 mm) and control group (0,200 mm) with respect to minimum wall thickness (P = 0.982). Minimum wall thickness was significantly lower in the mitomycin-C group (0,160 mm) comparison to the control group (0,200 mm) (P < 0.0001). Conclusion: It was detected that the simvastatin and MMC is not effective in preventing the tracheal stenosis, inflammation and fibrosis formation.Öğe Serum oxidative stress levels in patients with nasal septal deviation(Turkish Otorhinolaryngology Head and Neck Surgery Society, 2017) Ekinci, Adnan; Karataş, Duran; Yetiş, Abdurrahman; Demir, Emre; Özcan, MügeObjective: Comparison of the total oxidant status (TOS), total antioxidant status (TAS) and paraoxonase (PON1) serum levels in patients with nasal septum deviation (NSD) and healthy subjects.Methods: The TAS, TOS, and PON1 serum levels of 47 patients with NSD (mean age 35.3) and 50 healthy subjects (mean age 37.8) were compared in this study.Results: We found significantly higher TAS levels in the control group (p<0.001). The mean TAS value was 1.196 mmoL/L in the control group, whereas it was 1.046 mmoL/L in the NSD group. On the other hand, TOS was significantly higher in the NSD group (p<0.001). We found that the mean TOS value was 6.600 mmoL/L in the control group, and 20.194 mmoL/L in the NSD group. The NSD and control groups had similar PON1 levels (p=0.446). The mean PON1 value was 279.64 U/L in the control group, and 324.21 U/L in the NSD group. Conclusion: We detected higher TOS and lower TAS levels in patients with NSD compared to healthy subjects. These results indicate that patients with NSD are exposed to oxidative stress.Öğe Serum prolidase and oxidative stress levels in patients with recurrent aphthous stomatitis: a prospective, controlled study(Wolters Kluwer Medknow Publications, 2020) Ekinci, Adnan; Demir, Emre; Ekinci, HalilBackground: Recurrent aphthous stomatitis is a common disease characterized by single or multiple, self-healing, well-circumscribed, periodic ulcers occurring in the oral cavity. Although the relationship between recurrent aphthous stomatitis and oxidative stress has been extensively reviewed in the past, its relationship with prolidase enzyme levels has not been previously investigated. Aim: The aim of this study is to investigate plasma antioxidant status and prolidase enzyme levels in patients with recurrent aphthous stomatitis. Methods: The serum total oxidant status, total antioxidant status, oxidative stress index, prolidase and paraoxonase levels of 34 recurrent aphthous stomatitis patients (mean age 35.1) and 34 healthy controls (mean age 37.7) were compared in this study.Results: Total oxidant status was significantly higher in the recurrent aphthous stomatitis group (P < 0.005). The mean total oxidant status value was 5.19 mmol/L in the recurrent aphthous stomatitis group, while it was 2.90 mmol/L in the control group. Oxidative stress index was significantly higher in the recurrent aphthous stomatitis group (P = 0.016*). The mean oxidative stress index level was 0.28 AU in the recurrent aphthous stomatitis group, while it was 0.18 AU in the control group. When control and patient groups were compared, there was no significant difference between groups with regard to the total antioxidant status (P = 0.343). The total antioxidant status levels were 1.09 and 1.14 mmol/L in control and patient groups, respectively. There was no statistically significant difference between PON1 levels of recurrent aphthous stomatitis and control groups (P = 0.218). Mean PON1 levels were 326 /L in the recurrent aphthous stomatitis group and 381 U/L in the control group. Prolidase levels were not significantly different between recurrent aphthous stomatitis and control groups (P = 0.955). The mean prolidase level was 219.79 U/L in the recurrent aphthous stomatitis group and 219.26 U/Lin the control group Limitations: The limitation of this study is the small size of both patient and control groups and exclusion of pediatric patients., Similar studies performed in pediatric patient populations with a comparison to adults may be useful in providing meaningful results.Conclusions: We detected that the total oxidant status and oxidative stress index was higher in patients with recurrent aphthous stomatitis as compared to healthy controls. We could not demonstrate a significant difference in total antioxidant status, PON1 and prolidase values.Öğe The Effect of Nasal Septal Deviation on Serum Lipid Levels(2019) Karataş, Duran; Ekinci, Adnan; Yetiş, Abdurrahman; Özcan, MügeObjective: The aim of the study was to determine the effect of nasal septal deviation on serum lipids. Material and Methods: Thirty-two patients aged 18-53 with nasal septal deviation and nasal obstruction were included into this study. Serum lipid levels were determined before and after septoplasty. Results: There was no statistically significant difference in serum lipid levels before and after septoplasty (p=0.248, p=0.135, p=0.862, p=0.829). There was a statistically significant difference in the serum low-density lipoprotein cholesterol level between the patient and control group (p=0.024). Conclusion: This study showed that nasal septal deviations had no effect on serum lipids, except on low-density lipoprotein cholesterol. Septoplasty can reduce the speed of atherosclerosis progression in patients with both atherosclerosis and nasal septal deviation.Öğe The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps(Walter De Gruyter Gmbh, 2021) Ekinci, Adnan; Kayadibi, Hüseyin; Demir, Emre; Özcan, MügeObjective: To compare prolidase enzyme activity (PEA) in serum and polyp specimens of patients with nasal polyps obtained before and after the oral steroid therapy. Materials and methods: Thirty three patients with nasal polyps (39 +/- 13 years) received 1 mg/kg of oral steroids. Serum samples were collected from each patient, but nasal polyp specimens could be obtained only from 23 patients (38 +/- 13 years) before and after the oral steroid therapy. PEA was measured by ELISA method. Results: Serum PEA values were 210 (176-242) U/L and 184 (147-217) U/L before and after the oral steroid therapy, respectively (p = 0.015). Polyp tissue PEA was 1337 (738-2130) U/g and 871 (590-1663) U/g before and after the oral steroid therapy, respectively (p = 0.429). Conclusion: In patients with nasal polyps, significantly lower serum PEA after the oral steroid therapy may be a consequence of the role of prolidase enzyme in inflammatory processes which are important for the development of nasal polyps. More comprehensive studies with larger sample sizes are needed to elucidate the role of PEA in the pathogenesis of nasal polyps.Öğe The effects of septoplasty surgery on serum oxidative stress levels(Springer Verlag, 2017) Ekinci, Adnan; Karataş, Duran; Yetiş, Abdurrahman; Demir, Emre; Özcan, MügeThe aim of this study is to compare the total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) serum levels in patients who have undergone septoplasty (NSD). Forty-six patients (mean age 33.7) aged between 18 and 50 years who were diagnosed with nasal septal deviation (NSD) were included in the study. The TAS, TOS, and PON1 levels were compared in the serum samples obtained 1 month before the septoplasty and 3 months after surgery. There was a significant increase in mean TAS after septoplasty (1.041 vs. 1.124 mmol/L, p = 0.011). The mean TOS decreased significantly after septoplasty (20.631 vs. 5.946 mmol/L, p = 0.011). The mean pre- and postoperative PON1 levels were similar (326.93 ± 215.22 vs. 275.20 ± 167.76 U/L, p = 0.253). Increased TAS and decreased TOS after septoplasty show that patients with NSD are under oxidative stress that is relieved following septoplasty. © 2017, Springer-Verlag Berlin Heidelberg.Öğe The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps(Cambridge University Press, 2018) Ekinci, AdnanObjectives This study aimed to compare serum macrophage migration inhibitory factor concentrations before and after oral steroid therapy in nasal polyps patients, and determine whether there is a difference between pre-treatment macrophage migration inhibitory factor concentrations and healthy individuals.Methods The study included 24 patients with nasal polyps and 25 healthy individuals. The patient group received 1 mg/kg oral steroid.Results The mean macrophage migration inhibitory factor concentration before oral steroid therapy was 3889.79 pg/ml in the patient group and 2334.52 pg/ml in the control group. Macrophage migration inhibitory factor concentrations were statistically significantly higher in the pre-oral steroid therapy patient group than in the control group (p = 0.017). The mean pre- and post-oral steroid therapy serum macrophage migration inhibitory factor concentrations were 3889.79 pg/ml and 2451.25 pg/ml, respectively. The reduction in macrophage migration inhibitory factor concentrations was statistically significant (p = 0.010).Conclusion These findings suggest that concentrations of macrophage migration inhibitory factor may play a role in the pathogenesis of nasal polyps. Copyright © JLO (1984) Limited, 2018.Öğe The Effects of the Combined Use of Merocel and Silicone Nasal Packs on Pain, Bleeding, and Mucociliary Activity After Septoplasty(2021) Ekinci, Adnan; Dağıstan, HakanObjective: Epistaxis is one of the common complications after septoplasty. The type of packs more effective in preventing bleeding after the surgery is still a matter of debate. The aim of this study is to compare the effects of airway Doyle Silicone pack, Merocel pack, and the combination of Merocel and silicone packs on pain, bleeding, and mucociliary clearance after septoplasty. Material and Methods: This study is a prospective cohort study. A total of 75 patients who underwent septoplasty were divided into 3 groups: silicone pack was applied to the first group (termed group S), Merocel pack was applied to the second group (termed group M), and a combination of Merocel and silicone packs was applied to the third group (termed group M+S). The amount of bleeding, the intensity of pain, and mucociliary clearance duration were compared. Results: The amount of bleeding in group M+Swas significantly lower than that in group S (p<.001). The amount of bleeding in group M+Swas significantly lower than that in group M (P=.003). Pain was significantly lower in group S than in groups M and M+S (p<.001 and p=.024). Conclusion: It was determined that combined use of silicone and Merocel packs after septoplasty caused less bleeding than the useof silicone pack or Merocel pack alone. The combined use of Merocel and silicone packs can be a good alternative packing method because it reduces nasal bleeding after septoplasty.
