The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps
[ X ]
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cambridge University Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives This study aimed to compare serum macrophage migration inhibitory factor concentrations before and after oral steroid therapy in nasal polyps patients, and determine whether there is a difference between pre-treatment macrophage migration inhibitory factor concentrations and healthy individuals.Methods The study included 24 patients with nasal polyps and 25 healthy individuals. The patient group received 1 mg/kg oral steroid.Results The mean macrophage migration inhibitory factor concentration before oral steroid therapy was 3889.79 pg/ml in the patient group and 2334.52 pg/ml in the control group. Macrophage migration inhibitory factor concentrations were statistically significantly higher in the pre-oral steroid therapy patient group than in the control group (p = 0.017). The mean pre- and post-oral steroid therapy serum macrophage migration inhibitory factor concentrations were 3889.79 pg/ml and 2451.25 pg/ml, respectively. The reduction in macrophage migration inhibitory factor concentrations was statistically significant (p = 0.010).Conclusion These findings suggest that concentrations of macrophage migration inhibitory factor may play a role in the pathogenesis of nasal polyps. Copyright © JLO (1984) Limited, 2018.
Açıklama
Anahtar Kelimeler
Macrophage Migration-Inhibitory Factors, Nasal Polyps, Steroids
Kaynak
Journal of Laryngology and Otology
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
132
Sayı
10
Künye
Ekinci, A. (2018). The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps. The Journal of Laryngology & Otology, 132(10), 891-895.
