The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps

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dc.contributor.authorEkinci, Adnan
dc.date.accessioned2019-05-10T09:38:57Z
dc.date.available2019-05-10T09:38:57Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractObjectives This study aimed to compare serum macrophage migration inhibitory factor concentrations before and after oral steroid therapy in nasal polyps patients, and determine whether there is a difference between pre-treatment macrophage migration inhibitory factor concentrations and healthy individuals.Methods The study included 24 patients with nasal polyps and 25 healthy individuals. The patient group received 1 mg/kg oral steroid.Results The mean macrophage migration inhibitory factor concentration before oral steroid therapy was 3889.79 pg/ml in the patient group and 2334.52 pg/ml in the control group. Macrophage migration inhibitory factor concentrations were statistically significantly higher in the pre-oral steroid therapy patient group than in the control group (p = 0.017). The mean pre- and post-oral steroid therapy serum macrophage migration inhibitory factor concentrations were 3889.79 pg/ml and 2451.25 pg/ml, respectively. The reduction in macrophage migration inhibitory factor concentrations was statistically significant (p = 0.010).Conclusion These findings suggest that concentrations of macrophage migration inhibitory factor may play a role in the pathogenesis of nasal polyps. Copyright © JLO (1984) Limited, 2018.
dc.identifier.citationEkinci, A. (2018). The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps. The Journal of Laryngology & Otology, 132(10), 891-895.
dc.identifier.doi10.1017/S0022215118001652
dc.identifier.endpage895en_US
dc.identifier.issn0022-2151
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage891en_US
dc.identifier.urihttps://doi.org/10.1017/S0022215118001652
dc.identifier.urihttps://hdl.handle.net/11491/563
dc.identifier.volume132en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCambridge University Press
dc.relation.ispartofJournal of Laryngology and Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMacrophage Migration-Inhibitory Factorsen_US
dc.subjectNasal Polypsen_US
dc.subjectSteroidsen_US
dc.titleThe effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps
dc.typeArticle

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