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Öğe Determination of biofilm formation capacity of Metschnikowia reukaufii strain(Refik Saydam National Public Health Agency (RSNPHA), 2024) Büyüksırt Bedir, TubaObjective: Biofilm is a community of microorganisms attached to biotic or abiotic surfaces. Microorganisms that form biofilms cause much more serious medical and industrial problems than their planktonic forms. In this sense, the ability of microorganisms to form biofilms must be known and precautions must be taken. The aim of this study is to create stress in the Metschnikowia reukaufii MN622824 strain, whose inhibitory substance production increases under stress conditions, by trying different environmental conditions and to determine its effect on biofilm formation. In addition, to observe its effect on biofilm formation on stainless steel (SS) surfaces, which are frequently used in food machines. Methods: Biofilm formation was compared with the tube method and the microtitration plate method. For this purpose, 5 different media compositions containing 5% glucose, 10% glucose, 5% NaCl, 10% NaCl, containing no glucose and NaCl (sodium chloride), and 3 different incubation periods consisting of 3, 5 and 7 days were tested. Additionally, scanning electron microscopy imaging was performed to examine the adhesion of biofilm to stainless steel coupons. Results: In the tube method, the highest biofilm formation was observed after three days of incubation in tubes with 5% glucose added. No biofilm was formed in the tubes that were kept for seven days or 10% NaCl was added. In the microtitration plate method the strong biofilm formation (1.3022) was obtained after three days of incubation in a medium containing 5% glucose. In the control group without glucose and NaCl, moderate biofilm formation were observed on the 3rd day (0.7385) and the 5th day (0.6882). Biofilm formation was evaluated as absent or weak in media containing 10% glucose or NaCl. As glucose and NaCl concentrations increased, biofilm formation decreased. Reticular bond structure showing biofilm formation were imaged with a scanning electron microscope in the control group on days 3–5–7, 5% NaCl and 5% glucose concentration on the 3rd day, and 5% glucose concentration on the 5th day. Conclusion: Biofilm formation in food factories poses a significant health problem. It was observed that increasing NaCl, glucose concentration and incubation time negatively affected the biofilm formation of the Metschnikowia reukaufii strain. Biofilm formation decreases or disappears in yeasts exposed to stress conditions. It is thought that the data obtained will help in biofilm control. © (2024), (Refik Saydam National Public Health Agency (RSNPHA)). All rights reserved.Öğe Is using inhaled corticosteroid effective against COVID-19 pneumonia severity and mortality?(TURKISH ASSOC TUBERCULOSIS & THORAX, 2024) Kılıç, Hatice; Argüder, Emine; Civak, Musa; Demir, EmreIntroduction: It is known that the use of inhaled corticosteroids increases the incidence of pneumonia in patients followed up with the diagnosis of chronic asthma and chronic obstructive pulmonary disease (COPD). This study aimed to investigate the contribution of inhaled steroid use to pneumonia severity and mortality in cases with COVID-19 pneumonia. Materials and Methods: The study is a retrospective, observational study. Among the cases admitted to the pandemic clinic, patients diagnosed with COVID-19 pneumonia were included. The plan was to compare cases who received and did not receive inhaled corticosteroids in terms of pneumonia severity and mortality. In order to define risk factors for mortality, univariate and multivariable negative binomial regression analyses were performed. Results: In our study, it was observed that n= 540 (75%) cases did not receive inhaled corticosteroids (group 1), and 180 (25%) cases used inhaled corti costeroids (group 2). Group 1 and group 2 cases were compared in terms of pneumonia severity with no significant difference between the two groups (p= 0.11). Then, risk factors affecting mortality in all cases were examined with univariate analyses. Increasing age, applying mechanical ventilation, having severe pneumonia, having interstitial lung disease, and applying prone position were found to be statistically significant factors in mortality (p< 0.05). Conclusion: In conclusion, in our study, it was observed that the use of inhaled corticosteroids did not increase the severity of pneumonia and mortality. It was thought that the treatment they received could be continued when the patients treated with inhaled corticosteroids due to asthma and COPD had COVID-19 pneumonia.Öğe The effect of aerobic and high-intensity interval training on plasma pentraxin 3 and lipid parameters in overweight and obese women(PEERJ INC, 2024) Çiçek, Güner; Özcan, Oğuzhan; Akyol, Pelin; Işık, Özkan; Novak, Dario; Küçük, HamzaBackground. It is unclear whether different exercise programs lead to an increase in the concentration of plasma Pentraxin3 (PTX3), an anti-inflammatory protein. This study aimed to investigate the effects of aerobic exercise (AE) and high-intensity interval training (HIIT) on plasma PTX3 levels in overweight and obese women. Method. A total of 45 sedentary women aged between 32.26 ± 6.30 voluntarily participated in the study. The control group (CG, n = 15) was selected among normalweight women. Women in the group of participants who partook in exercise consisted of overweight and obese women according to a random method, including the AE group (n = 15) and the HIIT group (n = 15). The AE session conducted was 50 min in duration and consisted of warm-up exercises (5 min), and primary exercises (40 min, basic aerobic-step exercises). HIIT consists of warm-up exercises (5 min), primary exercises (work intervals: 6?10 × 1 min (80–90% HRmax), rest intervals: 1 min (walk, 50% HRmax), 21–29 min running. The exercises were applied for three sessions/week for 12 weeks. Fasting blood samples were taken from all participants before and after exercise and their body composition was measured. Results. As a result of two different 12-week exercises, serum PTX3 levels increased significantly by 47.53% in the AE group and 50.21% in the HIIT group (p < 0.01). It was determined that the mean PTX3 before and after exercise increased from 1.71 ± 0.43 to 2.47 ± 0.40 ng/dL and HIIT from 1.62 ± 0.39 to 2.31 ± 0.33 ng/dL. A significant decrease in body mass index (BMI) values were detected, approximately 5.81% in the AE group and 5.06% in the HIIT group (p < .01). A significant decrease was detected in glucose, insulin, HOMA-IR, LDL-C, and hsCRP whereas HDL-C and VO2max value increased significantly in both exercise groups (p < .05; p < .01). There were no significant differences in TG and TC levels between groups (p > .05). Also, no significant differences were found between the two types of exercises in terms of parameters. A significant negative correlation in the total sample was found between PTX3 with BMI, fat mass, LDL-C, and hsCRP.Öğe The surveillance and assessment of acute injuries in different age categories in national wrestling championships(Elsevier, 2024) Can, Sema; Demirkan, Erkan; Arıcı, Mustafa; Tosun, Mehmet İsmail; Cicioğlu, Halil İbrahimPurpose: The purpose of this study is to surveil the injuries in wrestling according to the different age categories and wrestling styles throughout the competition season. Methods: The study was designed as a descriptive study. The study was conducted during the wrestling competition season in 2023 (from January 2023 to July 2023), which includes 5 different age categories: U-15, U-17, U-20, U-23, and seniors, along with the Turkey National Wrestling Championships. The data of injuries was recorded immediately after the acute injury was treated by the medical expert during the competitions and evaluated according to the parameters that were obtained. In the statistical analysis, the frequency and percentage values were presented as descriptive statistics and the Chi-square test was used. Results: The study incorporated a total of 6214 wrestlers and a total of 7151 wrestling bouts were performed during these competitions. The analyses indicated that the rate of injury incidence was 42.65‰ in all wrestling styles. When taking account of the injured body parts in all wrestlers’ exposures, the occurrence of injuries to the head-face, neck, trunk, upper extremity, and lower extremity, rates of 17.6‰, 1.3‰, 3.6‰, 13.5‰, and 6.6‰, respectively, were observed. According to the pre-diagnosis based on freestyle, Greco-Roman, and female wrestling styles, injuries with bleeding (39.6%, 46.3%, and 14.6%, respectively) and muscle strain (37.9%, 28.7 %, and 52.6%, respectively) most often occurred. Conclusion: The study findings indicate that most cases of injury appeared to occur in bleeding and muscle strain in all wrestling styles. We suggest that medical experts should set up their health equipment with consideration to the injuries that occur most frequently.Öğe A study of crashworthiness performance in thin-walledmulti-cell tubes 3D-printed from different polymers(WILEY, 2024) Tunay, Merve; Bardakcı, AlperenMulticellular, thin-walled impact tubes have been intensely studied and usedin various engineering fields in recent years due to their lightweight, high per-formance, ease of application, superior energy absorption, and stable deforma-tion characteristics. In this study, energy absorption, crashworthinessperformances, and deformation properties of thin-walled structures manufac-tured from polylactic acid (PLA+) and acrylonitrile butadiene styrene (ABS)using fused deposition modeling (FDM) technology were compared underquasi-static axial compression. Thin-walled structures consist of multicellulartubes connected by concentric corner-edge connections with square and hex-agonal cross-sections. Experimental testing outcomes indicate that the energyabsorption capacity increases with increasing the number of corners in multi-cellular structures. The tubes with square wall-to-wall (S-WW) and hexagonalwall-to-wall (H-WW) cross-sections exhibit superior crashworthiness perfor-mance compared to other cross-sections. Based on the experimental results,the absorbed energy by WW patterned PLA+ square tubes are 19%, 7%, and46% more than that of wall-to-corner (WC), corner-to-wall (CW), and corner-to-corner (CC) patterned tubes, respectively, while it is 11%, 19%, and 80%more in hexagonal cross-section tubes, respectively. This study provides aninformative reference for easier applicability of multicellular energy-absorbingstructures with 3D-print and the design of corner-edge connections of internalconnections in multicellular structures.Öğe Health benefits and risks of fermented foods—the PIMENTO initiative(FRONTIERS MEDIA SA, 2024) Todorovic, Smilja; Akpınar, Aslı; Assunção, Ricardo; Güzel, MustafaWorldwide, fermented foods (FF) are recognized as healthy and safe. Despite the rapid increase of research papers, there is a lack of systematic evaluation of the health benefits and risks of FF. The COST Action CA20128 "Promoting innovation of fermented foods" (PIMENTO) aims to provide a comprehensive assessment on the available evidence by compiling a set of 16 reviews. Seven reviews will cover clinical and biological endpoints associated with major health indicators across several organ systems, including the cardiovascular, gastrointestinal, neurological, immune, and skeletal systems. Nine reviews will address broader biological questions associated with FF including bioactive compounds and vitamin production, nutrient bioavailability and bioaccessibility, the role of FF in healthy diets and personalized nutrition, food safety, regulatory practices, and finally, the health properties of novel and ethnic FF. For each outcome assessed in the reviews, an innovative approach will be adopted based on EFSA's published guidance for health claim submissions. In particular, each review will be composed of three parts: (1) a systematic review of available human studies; (2) a non-systematic review of the mechanism of action related to the clinical endpoints measured by the human studies identified in part 1; and (3) a non-systematic review of the characterization of the FF investigated in the human studies identified in part 1. The evidence and research gaps derived from the reviews will be summarized and published in the form of a strategic road map that will pave the way for future research on FF.Öğe Psychological Needs in Sports, Spirituality Index of Well-Being, and Motivation in Sports(MDPI, 2024) Eryücel, Mehmet Emre; Ceyhun, Serdar; Eryücel, Sema; Şahan, Hasan; Turna, Bülent; Yıldırım, Sibel; Erdoğan, İbrahim HalilAbstract: The aim of this study is to examine the relationship between the psychological needs of athletes who attend gyms, the spirituality index of well-being, and motivation in sports, and to determine the mediating role of the spirituality index of well-being between psychological needs in sports and motivation in sports. Although sports spirituality is rapidly developing in the international literature, sports and spirituality have not been studied together in the national literature before. Therefore, this study holds the distinction of being one of the pioneering research efforts on the subject of spirituality in athletes in Türkiye. In this context, the data of 422 athletes, 176 women and 246 men, who have been attending gym facilities in Antalya for at least one year, were included in the research. Participants were administered a personal information form, Psychological Need States. It was found that the spirituality index of well-being is positively related to all satisfaction subscales and negatively related to all frustration subscales of psychological needs and that the life scheme is related to many subscales of sport motivation. Furthermore, it was also found that the spirituality index of well-being is a mediating variable between psychological needs in sports and motivation in sports. The data draw attention to the importance of sports spirituality. It is recommended to integrate spirituality into healthcare for athletes.Öğe Teachers' digital competences: a scale construction and validation study(FRONTIERS MEDIA SA, 2024) Aydın, Mehmet Kemal; Yıldırım, Turgut; Kuş, MetinIntroduction: Improving teachers’ digital competences is sine qua non for eective teaching and learning in today’s digital society. However, there is a limited number of comprehensive and reliable scales to measure teachers’ digital competences. Regarding this, the present study aimed to develop and validate a comprehensive scale to assess teachers’ digital competences. Methods: Building on previous studies, a draft scale developed and piloted with a sample of teachers from all educational levels. The procedures of Exploratory Factor Analysis (EFA) were followed to refine the scale, resulting in a fivepoint Likert scale with 36 items loaded onto four factors. The final scale was called as Teachers’ Digital Competences Scale (TDC-S). Confirmatory factor analysis (CFA) was employed to validate the four-factor structure. Reliability analysis was performed using Cronbach’s alpha (?), McDonald’s omega (?), and Composite Reliability (CR), indicating high psychometric properties. Convergent and discriminant validity analyses were also performed to assess the validity of the latent structures in TDC-S. Results and discussion: The findings suggest that the TDC-S is a valid and reliable instrument for assessing teachers’ digital competences at all grade levels from primary to high schools. It can be used to inform teacher training and development programs, and to identify teacher candidates who need additional assistance regarding improving their digital competencesÖğe Heart Failure Awareness Survey in a Turkish Population: HFAS-TR(KARE PUBL, 2024) Karabulut, Dilay; Günay, Şeyda; Sert Şekerci, Sena; Bekar, LütfüObjective: Heart failure is a leading cause of death and the most common diagnosis leading to hospitalization. Its awareness is lower than that of other cardiovascular diseases, both in the general population and among patients with heart failure (HF). This study aimed to establish the current level of knowledge about HF in patients with HF with reduced ejection fraction (HFrEF) and mildly reduced ejection fraction (HFmrEF) in Türkiye. Methods: This questionnaire-based survey study is multicenter, conducted across 34 centers from December 2021 to July 2022. We performed a survey consisting of two sets of questions focusing on individual characteristics of the patients and HF-related knowledge. Results: The study included a total of 2,307 outpatient HF patients, comprising 70.5% males and 29.5% females with a mean age of 64.58 ± 13 (56-74) years and a mean body mass index value of 32.5 ± 10 kg/m2. HFrEF and HFmrEF were determined in 74.7% and 25.3% of patients, respectively. Thirty percent of the patients were unaware that they had HF. While 28.7% of the patients thought that they had sufficient information about HF, 71.3% believed they lacked adequate knowledge. In the study, 25.2% of the participants identified dyspnea, 22% identified tiredness, and 25.4% identified leg edema as the most common symptoms of HF. Only 27.4% of patients recognized all three typical symptoms of HF. Conclusion: We found that the study population’s knowledge about HF symptoms and the nature of the disease was poor. Educational and awareness activities are necessary to optimize outcomes and benefits.Öğe Investigating AXIN1 gene polymorphisms in Turkish children with cryptorchidism: A pilot study(ELSEVIER SCI LTD, 2024) Doğan, Gül; Yılmaz, Akın; İpek, Hülya; Metin, Mehmet; Peltek Kendirci, Havva Nur; Afşarlar, Çağatay EvrimIntroduction Cryptorchidism is one of the most common congenital anomalies in male children, occurring in 2e5% of full-term male infants. Both genetic and environmental factors are observed to play a role in its etiology. A study conducted in Japan identified the AXIN1 gene as being associated with cryptorchidism. Objective We aimed to conduct a pilot study on AXIN1 gene polymorphism in Turkish children with cryptorchidism, and whether AXIN1 gene polymorphism is a risk factor for cryptorchidism. Study design Between January 2023 and December 2023, we have planned a prospective controlled study including 84 boys operated for cryptorchidism as study group, and 96 boys operated for circumcision as control group. The remaining blood samples of preoperative laboratory tests in ethylenediamine tetraacetic acid (EDTA) tubes were kept at 20 Co freezer for genomic studies. Patient demographics, physical examination and operative findings were recorded, study patients were grouped according to testis localization. After collecting all samples, genomic DNA isolation procedure was done, and analysis of the 3 polymorphisms (rs12921862, rs1805105 and rs370681) of AXIN1 gene was performed using conventional Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) method. Genotype and allele frequencies of each group was analyzed and compared. Results The most common location of cryptorchid testis was proximal inguinal (53%), followed by distal inguinal (25.3%), bilateral (13.3%), and intra-abdominal (8.4%). Regarding the 3 polymorphisms of AXIN1 gene, there was no significant difference between study and control groups, in terms of genotype and allele frequencies (P > 0.05). Eight haplotype blocks were estimated for 3 polymorphisms of AXIN1. However, no significant difference was observed between study and control groups regarding haplotype distributions (P > 0.05). In addition, the comparison of the localization of testis with AXIN1 gene polymorphism did not show any significant difference among cryptorchid testis groups (P > 0.05). Discussion The AXIN1 gene is located on chromosome 16p and its polymorphisms have been associated with various diseases. In a Chinese study, the rs370681 polymorphism was found to be associated with cryptorchidism. However, our results showed no association between the AXIN1 gene haplotypes for the studied polymorphisms and cryptorchidism. Conclusion In this study we have investigated the AXIN1 gene polymorphism in Turkish children with cryptorchidism as a pilot study. Although we could not identify any difference as compared to control group, further research is necessary to uncover the underlying molecular mechanisms contributing to the development of cryptorchidism.Öğe Predictive Value of Serial Rapid Shallow Breathing Index Measurements for Extubation Success in Intensive Care Unit Patients(MDPI, 2024) Turhan, Semin; Tutan, Duygu; Şahiner, Yeliz; Kısa, Alperen; Önen Özdemir, Sibel; Tutan, Mehmet Berksun; Kayır, Selçuk; Doğan, GüvençAbstract: Background and Objectives: Extubation success in ICU patients is crucial for reducing ventilator-associated complications, morbidity, and mortality. The Rapid Shallow Breathing Index (RSBI) is a widely used predictor for weaning from mechanical ventilation. This study aims to determine the predictive value of serial RSBI measurements on extubation success in ICU patients on mechanical ventilation. Materials and Methods: This prospective observational study was conducted on 86 ICU patients at Hitit University between February 2024 and July 2024. Patients were divided into successful and unsuccessful extubation groups. RSBI values were compared between these groups. Results: This study included 86 patients (32 females, 54 males) with a mean age of 54.51 ± 12.1 years. Extubation was successful in 53 patients and unsuccessful in 33. There was no significant difference in age and intubation duration between the groups (p = 0.246, p = 0.210). Significant differences were found in RSBI-1a and RSBI-2 values (p = 0.013, p = 0.011). The median RSBI-2a was 80 in the successful group and 92 in the unsuccessful group (p = 0.001). The ?RSBI was higher in the unsuccessful group (p = 0.022). ROC analysis identified optimal cut-off values: RSBI-2a ? 72 (AUC 0.715) and ?RSBI ? ?3 (AUC 0.648). RSBI-2a ? 72 increased the likelihood of successful extubation by 10.8 times, while ?RSBI ? ?3 increased it by 3.4 times. Using both criteria together increased the likelihood by 28.48 times. Conclusions: Serial RSBI measurement can be an effective tool for predicting extubation success in patients on IMV. These findings suggest that serially measured RSBI may serve as a potential indicator for extubation readiness.Öğe Data privacy-aware machine learning approach in pancreatic cancer diagnosis(BMC, 2024) Akmeşe, Ömer FarukProblem Pancreatic ductal adenocarcinoma (PDAC) is considered a highly lethal cancer due to its advanced stage diagnosis. The fve-year survival rate after diagnosis is less than 10%. However, if diagnosed early, the fve-year survival rate can reach up to 70%. Early diagnosis of PDAC can aid treatment and improve survival rates by taking necessary precautions. The challenge is to develop a reliable, data privacy-aware machine learning approach that can accurately diagnose pancreatic cancer with biomarkers. Aim The study aims to diagnose a patient’s pancreatic cancer while ensuring the confdentiality of patient records. In addition, the study aims to guide researchers and clinicians in developing innovative methods for diagnosing pancreatic cancer. Methods Machine learning, a branch of artifcial intelligence, can identify patterns by analyzing large datasets. The study pre-processed a dataset containing urine biomarkers with operations such as flling in missing values, cleaning outliers, and feature selection. The data was encrypted using the Fernet encryption algorithm to ensure confdentiality. Ten separate machine learning models were applied to predict individuals with PDAC. Performance metrics such as F1 score, recall, precision, and accuracy were used in the modeling process. Results Among the 590 clinical records analyzed, 199 (33.7%) belonged to patients with pancreatic cancer, 208 (35.3%) to patients with non-cancerous pancreatic disorders (such as benign hepatobiliary disease), and 183 (31%) to healthy individuals. The LGBM algorithm showed the highest efciency by achieving an accuracy of 98.8%. The accuracy of the other algorithms ranged from 98 to 86%. In order to understand which features are more critical and which data the model is based on, the analysis found that the features “plasma_CA19_9”, REG1A, TFF1, and LYVE1 have high importance levels. The LIME analysis also analyzed which features of the model are important in the decision-making process. Conclusions This research outlines a data privacy-aware machine learning tool for predicting PDAC. The results show that a promising approach can be presented for clinical application. Future research should expand the dataset and focus on validation by applying it to various populations.Öğe From Captivity to Liberty: A Study on the Prison Writings of Martin L. King, Ngugi and Soyinka(Rector CIU Cyprus Int Univ, 2024) Bolat, Eren; Ekler, OnurPrisons, like other disciplining apparatuses of the state, are used to reform the prisoners so that they can be re-conditioned back to a set of pre-ordained roles designed in the system. These are places hostile to individuality, freedom, and creativity. They function like rehabilitating institutes to suppress the reactionary or rebellious voices of the prisoners by effacing their individuality under harsh conditions so that they can make them docile bodies. However, this objective fails when the prisoner-intellectuals are of concern. For them, prisons become their shrines where they are overwhelmed by the transformative power of imprisonment. The experience of confinement shapes their perspectives, deepens their commitment to social justice, and fuels their advocacy for change. Although the physical conditions of the prisons hamper their urge to write, they never give up writing. Some write on the prison walls and some on toilet papers. Despite such horrible conditions, they manage to produce their most influential works which can be classified in prison literature. The writings of these prisoner-writers have paved the way for the liberation of colonized/discriminated people in their own countries and in diverse diasporas. Martin L. King’s Letter from Birmingham Jail (2018), Ngugi wa Thiong’o’s Detained: A Writer’s Prison Diary (1981) and Wole Soyinka’s The Man Died: The Prison Notes (1988) are three significant works to be featured in this genre. Through an interdisciplinary approach, this article identifies the distinctive elements and commonalities in the prison writings of King, Ngugi, and Soyinka. This study explores the universal concepts of incarceration, resistance to oppressive systems, and the struggle for freedom as portrayed in the works of these writers, and aims to examine how these writers have transformed their works into tools of resistance.Öğe MO-CCCII-Based Single-Input Multi-Output (SIMO) Current-Mode Fractional-Order Universal and Shelving Filter(MDPI, 2024) Şen, Fadile; Kırcay, Ali; Sonbaş Cobb, Buket; Akgül, AkifThis study introduces an innovative filter topology capable of providing simultaneous positive and negative gain outputs for one-fractional order LP, with high-pass, all-pass, and fractional-order shelving filter responses. The circuit, utilizing multi-output second-generation current-controlled conveyors, stands out as the first to deliver ten outputs, incorporating both integer and fractional-order filter responses, without requiring additional components. Its current-mode design simplifies the process, employing minimal active and grounded passive elements, making it appropriate for low-voltage/low-power applications. The filter utilizes fifth-order Oustaloup approximation and Foster type-I RC networks for fractional-order capacitors, providing enhanced control over the transition slope. PSpice simulations confirmed a 1 kHz cut-off, showcasing low power consumption, minimal noise, and a wide dynamic range, positioning the filter as suitable for sensors, control, and acoustic applications.Öğe Service Quality and Related Factors in Primary Health Care Services: A Cross-Sectional Study(MDPI, 2024) Değer, Mehmet Sait; Issever, HalimPrimary health care services aim to prevent diseases and improve health efficiently and effectively. This study measures perceived service quality in a primary healthcare organization and examines the effect of personality traits on service quality. The cross-sectional study population comprised individuals over the age of 18 who applied to the Bing & ouml;l Central Community Health Centre. A total of 460 participants were included in the study between November 2018 and March 2019. The participants completed a face-to-face questionnaire that included socio-demographic characteristics, the SERVQUAL Scale, and an abbreviated form of the revised Eysenck Personality Questionnaire. This study is based on doctoral research in public health. The study found median values for personality trait sub-dimensions as follows: neuroticism: 2, psychoticism: 2.65, extraversion: 4, and lying: 5. The SERVQUAL Score was -0.02. The study revealed that the quality of primary health care services did not meet the participants' expectations. The study findings also indicated that age, educational attainment, and extraverted and psychotic personality traits were significantly associated with the satisfaction of service quality expectations (p < 0.05). It is recommended to provide primary health care services in facilities with good physical characteristics, with sufficient and competent health personnel, and in a timely and accurate manner to improve service quality.Öğe Assessment of frailty, daily life activities, and nutrition of elderly immigrants: A household based cross-sectional study(LIPPINCOTT WILLIAMS & WILKINS, 2024) Değer, Mehmet Sait; Sezerol, Mehmet Akif; Atak, MuhammedWith the global migrant population on the rise, it's imperative to focus on the health status of more vulnerable groups within these communities. The elderly immigrants face myriad physical and psychosocial challenges that significantly impact their health and quality of life. This study aims to investigate the nutrition, daily life activities, and clinical frailty status of elderly immigrants residing in T & uuml;rkiye. A cross-sectional design was employed in the Sultanbeyli District, focusing on Syrian immigrants aged 65 and over. Participants were surveyed face-to-face by interpreters proficient in Arabic. The questionnaire comprised sociodemographic details, health status, and scales like Katz Daily Life Activities, Clinical Frailty, and Mini Nutritional Assessment. The data analysis was executed using SPSS 22. Continuous variables were presented as mean +/- standard deviation (SD) and median, while categorical ones were expressed in numbers and percentages (%). A significance level of P < .05 was considered for the analyses. The average age of the participants was determined as 71.64 +/- 6.20 years. In the study group, 49.7% were female, 75.5% were younger than 75 years old, 47.7% had less than primary school education, 56.3% were married, 42.4% had a low income level, and 56.9% lived in the same household with 5 or more people. Among the participants in the study group, 47% had walking and balance problems, 29.1% had a history of falls in the last year, 10.6% were disabled, 69.5% complained of pain, 82.8% had a chronic illness, and 43% had polypharmacy. The median value of the KATZ Daily Living Activities scale was 6, the mean score of the Clinical Frailty Score scale was 3.25 +/- 1.25, and the mean score of the Mini Nutritional Assessment scale was 12.40 +/- 2.15. Among immigrant elderly individuals, 88.1% were able to sustain their lives independently, 13.9% were clinically frail, and 3.3% were at risk of malnutrition. Factors such as age, level of education, socioeconomic status, marital status, number of cohabitants in the household, BMI, neurological problems, walking-balance disorders, disability, and presence of chronic diseases are associated with daily life activities, frailty, and malnutrition status. It is believed that broader field research with greater participation would be beneficial for evaluating the nutritional status of immigrant elderly individuals.Öğe Investigation of the relationship between ACAN geneVNTR polymorphism and Alzheimer’s disease inTurkish population(TAYLOR & FRANCIS INC, 2024) Keskin, Tuğba; Avşar, Orçun; Eliaçık, Sinan; Uysal Tan, FundaAlzheimer’s disease is one of the most common causes of dementia and is a neurodegenerative disease that occurs with memory loss, loss of language, thinking and problem-solving skills. In this study, it was aimed to reveal the relationship between Alzheimer’s disease and the variable number tandem repeat (VNTR) polymorphism in the aggrecan (ACAN) gene. Thus, it is thought that it will contribute to enlightenment about disease by contributing to the pathophysiology of Alzheimer’s disease. A total of 203 people, including 102 patients diagnosed with Alzheimer’s and 101 healthy individuals, were included in the study. Deoxyribonucleic acid (DNA) extraction was performed from the blood samples taken. The variable number tandem repeat (VNTR) polymorphism of the ACAN gene was determined using the Polymerase Chain Reaction (PCR) method. In our study, the 30?R, 31?R and 33?R alleles were the most repetitive alleles in patients and controls. 30?R, 31?R and shorter alleles were more common in patients than in the control group and were found to be statistically significant (p?=?0.042). According to our results, 30?R and 31?R alleles of the VNTR polymorphism in the ACAN gene may be associated with Alzheimer’s disease. In addition, having less than 30 repeat alleles increases the risk of the disease by 2,202 times. Our study is the first to investigate the relationship between ACAN gene VNTR polymorphism and Alzheimer’s disease. Further studies are needed to definitively relate it.Öğe Association between Alzheimer’s disease, MAPT genemutation and some biochemical biomarkers(TAYLOR & FRANCIS INC, 2024) Şen, Ayşenur; Avşar, Orçun; Eliaçık, Sinan; Uysal Tan, FundaAlzheimer’s Disease (AD) is a multifactorial neurodegenerativedisease and there is still no definitive treatment today. Earlydiagnosis of the disease is important, but there are almost nobiomarkers that can be used in early diagnosis. The cerebro-spinal fluid used in the diagnosis of the disease is not suffi-cient and is very difficult to obtain. Therefore, blood biomarkersthat are less costly, less invasive, easily accessible, and can beused in long-term studies would be a better alternative. Theaim of this study is to determine the relationship betweenAlzheimer’s Disease and P301L MAPT gene mutation, homo-cysteine, folate and uric acid. 101 Alzheimer’s patients and101 healthy individuals were included in this study. Mutationanalysis was performed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) methodwith blood samples taken from the subjects. There was nosignificant difference between the patient and control groupsin terms of homocysteine (p = 0.771), folate (p = 0.366) and uricacid (p = 0.860). When the genotypes were compared betweenthe patient and control groups in terms of MAPT gene muta-tion (P301L), no statistically significant difference was detected(p = 0.081). There are very few studies in the literature investi-gating the relationship between Alzheimer’s disease and P301LMAPT gene mutation. Additionally, there is no study investigat-ing the relationship between Alzheimer’s disease and homocys-teine, folate, uric acid and P301L MAPT mutation in the Turkishpopulation. We believe that this study has shed light on futurestudies.Öğe Vortioxetine treatment for neuropathic pain in major depressive disorder: a three-month prospective study(FRONTIERS MEDIA SA, 2024) Eliaçık, Sinan; Erdoğan Kaya, AyşeIntroduction and objective: Several studies revealed the therapeutic potential of vortioxetine (Vo) for pain. In this context, we aimed to evaluate the efficacy of Vo as a safe and tolerable novel pharmacologic agent in treating neuropathic pain (NP) in patients with major depressive disorder (MDD). Materials and methods: The population of this cross-sectional prospective study consisted of all consecutive patients who were newly diagnosed with MDD by a neurology doctor at a psychiatric clinic and had NP for at least 6? months. All patients included in the sample were started on Vo treatment at 10? mg/ day. They were assessed with Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Self-Reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), Douleur Neuropathique 4 Questions (DN4), Montreal Cognitive Assessment (MoCA), and Neuropathic Pain Impact on Quality of Life (NePIQoL) at the beginning of treatment and during the follow visits conducted at the end of the first, second and third months of the treatment. During these follow-up visits, patients were also queried about any side effects of Vo. Results: The mean age of 50 patients included in the sample, 76% of whom were female, was 45.8? ±? 11.2? years. There was a significant reduction in patients’ NP complaints based on DN4 and S-LANNS, the subscales of NePIQoL, and significant improvement in MoCA. There was a significant reduction in patients’ NP complaints based on DN4 and S-LANNS scores and a significant improvement in scores of the subscales of NePIQoL and MoCA. Conclusion: The study’s findings indicate that Vo, with its multiple mechanisms of action, can effectively treat NP independently of its mood-stabilizing effect. Future indication studies for Vo are needed to establish Vo’s efficacy in treating NP.Öğe Images Download Cite Share Favorites Permissions Research Article: Observational Study The evolution of Pemphigus publications: A bibliometric analysis with research trends and global productivity(LIPPINCOTT WILLIAMS & WILKINS, 2024) Öztekin, Aynure; Öztekin, CoşkunDespite an increase in global research on the subject of Pemphigus, which seriously affects patient health and quality of life, there is no bibliometric research on this subject in literature to date. The aim of this study was to conduct a holistic analysis of scientific articles published on Pemphigus, using bibliometric methods. Articles published on the subject of Pemphigus between 1980 and 2021 were downloaded from the web of science (WoS) database and analyzed using various statistical methods. To determine trend subjects, collaboration between countries, and the most effective studies with citation analyses, visual network maps were obtained with bibliometric analyses. A total of 3034 articles were analyzed. The 3 countries making the greatest contribution to literature were the USA (n:831, 27.3%), Japan (n:402, 13.2%), and Germany (n:221, 7.2%). The 3 most active institutions were Keio University (n:163, 5.3%), Kurume University (n:130, 4.2%) and Tel Aviv University (n:107, 3.5%). The 3 journals publishing the most articles were the British Journal of Dermatology (n: 88), Journal of the American Academy of Dermatology (n:171) and the Journal of Investigative Dermatology (n:143). The 3 leading journals according to the mean number of citations (NC) per article (citation count: CC) were the New England Journal of Medicine (CC:246), the Lancet (CC:143) and the Journal of Cell Biology (CC:133). The author with the most articles published was Hashimoto Takashi (n.168, 5.5%). As a result of cluster analysis, it was seen that 9 different main clusters had been studied on Pemphigus subjects to date (1: desmoglein, 2: paraneoplastic Pemphigus (PNP) – Pemphigus types-desmosome, 3: desmoglein 1 ve 3-autoimmunity, 4: treatment-rituximab, 5: acantholysis-apoptosis, 6: quality of life-remission-relapse, 7: autoantibodies, 8: epidemiology-mortality, 9: corticosteroids). The most commonly studied subjects were determined to be pemphigus vulgaris (PV), pemphigus foliaceus (PF), autoimmunity, rituximab, PNP, desmoglein (desmoglein3-desmoglein1), autoantibodies, acantholysis, autoantibody, treatment, autoimmune disease, desmosome, ELISA, and immunofluorescence. The primary trending topic was rituximab drug, which is used in the treatment of Pemphigus. The other most studied trend topics were azathioprine drug used in treatment, intravenous immunoglobulin treatment, quality of life, mortality rates, Pemphigus herpetiformis, and wound healing. Abbreviations: AC = average citation per article, CC = citation count, CI = confidence interval, GDP = gross domestic product, HDI = human development index, NC = number of citations, PF = pemphigus foliaceus, PNP = paraneoplastic Pemphigus, PV = pemphigus vulgaris, UK = United Kingdom, USA = United States of America, WoS = web of science.
