Is using inhaled corticosteroid effective against COVID-19 pneumonia severity and mortality?
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TURKISH ASSOC TUBERCULOSIS & THORAX
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: It is known that the use of inhaled corticosteroids increases the incidence of pneumonia in patients followed up with the diagnosis of chronic asthma and chronic obstructive pulmonary disease (COPD). This study aimed to investigate the contribution of inhaled steroid use to pneumonia severity and mortality in cases with COVID-19 pneumonia. Materials and Methods: The study is a retrospective, observational study. Among the cases admitted to the pandemic clinic, patients diagnosed with COVID-19 pneumonia were included. The plan was to compare cases who received and did not receive inhaled corticosteroids in terms of pneumonia severity and mortality. In order to define risk factors for mortality, univariate and multivariable negative binomial regression analyses were performed. Results: In our study, it was observed that n= 540 (75%) cases did not receive inhaled corticosteroids (group 1), and 180 (25%) cases used inhaled corti costeroids (group 2). Group 1 and group 2 cases were compared in terms of pneumonia severity with no significant difference between the two groups (p= 0.11). Then, risk factors affecting mortality in all cases were examined with univariate analyses. Increasing age, applying mechanical ventilation, having severe pneumonia, having interstitial lung disease, and applying prone position were found to be statistically significant factors in mortality (p< 0.05). Conclusion: In conclusion, in our study, it was observed that the use of inhaled corticosteroids did not increase the severity of pneumonia and mortality. It was thought that the treatment they received could be continued when the patients treated with inhaled corticosteroids due to asthma and COPD had COVID-19 pneumonia.
Açıklama
Anahtar Kelimeler
COVID-19, Asthma, COPD, Inhaled corticosteroid, Mortalit
Kaynak
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
Sayı
Künye
Kılıç H, Argüder E, Civak M, Gemcioğlu E, Kaya Kalem A, Hasanoğlu İ, et al. Is using inhaled corticosteroid effective against OVID19 pneumonia severity and mortality? Tuberk Toraks 2024;72(3):219-228.
