WoS İndeksli Yayınlar Koleksiyonu

Bu koleksiyon için kalıcı URI

https://hdl.handle.net/11491/5946

Listeleniyor 1 - 20 / 3277

Comments on the relationship between microRNA-155-5p and postoperative inflammatory markers in children with acute suppurative appendicitis, and its role in predicting postoperative complications
(TURKISH J PEDIATRICS, 2025) Coşkun, Nurcan
Dear Editor, I read with interest the study by Dr. Duan et al.1 titled “The relationship between microRNA-155-5p and postoperative inflammatory markers in children with acute suppurative appendicitis and its role in predicting postoperative complications” published in The Turkish Journal of Pediatrics.
A scoping review of the health effects of fermented foods in specific human populations and their potential role in precision nutrition: current knowledge and gaps
(FRONTIERS MEDIA SA, 2025) Humblot, Christele; Alvanoudi, Panagiota; Alves, Emilia; Assuncao, Ricardo; Belovic, Miona; Bulmuş Tüccar, Tuğçe; Karagöz, Mustafa Fevzi
Background: Diets and specific foods have a significant impact on health, and individual responses to nutritional factors vary. This variability among humans can be considered a basis for developing personalized or precision nutrition. Fermented foods (FF) contain a wide range of macro- and micronutrients, bioactive compounds, and live or dead microorganisms. FF represent a diverse range of products and have garnered significant interest due to their potential health benefits. However, consistent evidence remains limited, possibly due to heterogeneity in individual responses. Objectives: The objective of this review is to assess and compile existing evidence on the variable responses of populations to FF and to determine whether FF could be integrated into a precision nutrition strategy. Design: Interventional and observational human studies were systematically collected. The publication identified the main factors likely to contribute to variable responses to FF across all health outcomes. The question was systematically addressed to assess the available evidence and identify knowledge gaps, guiding future research. A pragmatic approach was employed, following EFSA health claim guidelines, which require an assessment of food characteristics and mechanisms of action, as well as conducting a systematic search of human interventional studies. A similar approach was used to analyze data extracted from observational studies. The population included all humans (healthy and non-healthy, of all ages), encompassing both observational and interventional studies. The intervention consisted of the ingestion of any FF, while the control was defined as the absence or lower consumption of FF or consumption of a corresponding non-FF. Outcomes included all markers of the population's health status. Results: The main factors contributing to variable responses to FF across all health outcomes were related to initial phenotypic characteristics (biological sex, geographical origin, hormonal status, and age), baseline health status [metabolic syndrome [MetS], chronic metabolic pathologies, cancer, and psychological disorders], and genetic background. Additionally, since the gut microbiota is person-specific and influences metabolic responses, particular attention was paid to its functions and role in the variability of population responses to FF. Conclusion: Collectively, this review represents a first step toward evaluating the feasibility of using FF in tailored nutritional strategies. Systematic review registration: https://osf.io/69d3f/overview.
Long-Term Cardiac Outcomes Following Renal Denervation: A Need for Imaging-Based Evidence
(WILEY, 2025) Çelik, Muhammet Cihat; Çelik, Ömer Burak; Kalçık, Macit
Dear Editor, We read with interest the article by Sesa-Ashton et al., which examined electrocardiographic changes in left ventricular mass index (LVMI) and atrial fibrillation (AF) incidence over more than 8 years of follow-up after renal denervation (RDN) [1].
Ultrafiltration pattern in automated peritoneal dialysis
(OXFORD UNIV PRESS, 2025) Sayarlıoğlu, Hayriye; Türkmen, Ercan; Doğan, İbrahim; Çınar, Ersin; Uçar, Emel
Methodological Considerations in Blood Pressure Variability Assessment for Branch Atheromatous Disease
(WILEY, 2025) Aker, Mücahit; Kalçık, Macit; Bekar, Lütfü
Dear Editor, The recent multicenter study examining the relationship between systolic blood pressure variability (BPV) and 90-day functional outcomes in branch atheromatous disease (BAD) provides valuable data on a clinically challenging stroke subtype [1].
Real-world outcomes and prognostic factors in primary mediastinal B-cell lymphoma: a multicenter study of 157 patients
(SPRINGER, 2025) Küçükyurt, Selin; Koca, Oğuzhan; Demirsoy, Esra Terzi; Akın, Serkan; Doğan, Ali; Yıldız, Abdülkerim
Primary mediastinal B-cell lymphoma (PMBCL) is a rare and distinct subtype of non-Hodgkin lymphoma. No consensus exists on optimal frontline treatment, and the use of R-CHOP +/- radiotherapy (RT) and DA-EPOCH-R +/- RT remains common, yet comparative real-world data are limited. In our multicenter retrospective study, we analyzed PMBCL patients, stratified by the first-line therapy (R-CHOP-21 +/- RT or DA-EPOCH-R +/- RT). Primary outcomes were complete response (CR) rate, progression-free survival (PFS), and overall survival (OS), alongside assessment of treatment-related toxicities and prognostic factors for PFS and OS. We included 157 patients [R-CHOP +/- RT group (n = 80) and DA-EPOCH-R +/- RT group (n = 77)] with a median age of 31 years, of whom 68.2% were female. CR rates were similar for R-CHOP +/- RT (75%) and DA-EPOCH-R +/- RT (76.6%). RT use was higher in the R-CHOP group (41.2% vs. 19.5%, p = 0.002). DA-EPOCH-R had significantly higher toxicity (29.9% vs. 16.2%, p = 0.033). The median follow-up of the entire cohort was 29 months with 2-year PFS and OS rates of 73.9% and 83.6%, respectively. Also, PFS and OS did not differ between regimens. In patients achieving CR with R-CHOP, RT omission did not impact survival. Multivariate analysis identified older age, poor performance status, superior vena cava syndrome and splenic involvement as independent OS predictors, while pericardial effusion, splenic involvement and hemoglobin < 10.5 g/dL were linked to inferior PFS. R-CHOP-21 +/- RT and DA-EPOCH-R +/- RT provide comparable efficacy in PMBCL. Due to the higher toxicity of DA-EPOCH-R, for those achieving CR following R-CHOP, selective RT omission may be a reasonable alternative. Established and disease-specific prognostic factors should guide individualized treatment strategies.
Impact of the COVID-19 Pandemic on CLABSI Rates and Antibiotic Resistance: A Multicenter Study in Türkiye
(DOC DESIGN INFORMATICS CO LTD, 2025) Sargın Altınok, Elif; Keşke, Şiran; Batırel, Ayşe; Bilgin, Hüseyin; Akdoğan, Özlem
Objective: The COVID-19 pandemic significantly disrupted infection control practices in healthcare settings. Previous studies have reported increased rates of central line-associated bloodstream infections (CLABSI), particularly during the early stages and peak periods of the pandemic. This multicenter study aimed to evaluate the impact of the COVID-19 pandemic on CLABSI rates in T & uuml;rkiye over a four-year period from 2019 to 2022. Materials and Methods: We conducted a retrospective analysis of prospectively collected CLABSI data from hospitals across various regions of T & uuml;rkiye between 2019 and 2022. The study period was divided into three phases: pre-pandemic, early pandemic, and late pandemic. Demographic and clinical characteristics, mortality rates, and microbiological data were analyzed. Pathogen distribution and antibiotic resistance patterns were compared between the pre-pandemic and pandemic periods. Results: A total of 25 hospitals participated in the study. The CLABSI rates per 1000 catheter days were 4.26 in 2019, 4.13 in 2020, 3.68 in 2021, and 3.53 in 2022. Across all periods, 3238 pathogens were identified. Gram-negative bacteria predominated both before and during the pandemic, with Acinetobacter baumannii (18.6%) and Klebsiella pneumoniae (17.8%) being the most common. Notably, an increase in carbapenem and colistin resistance in K. pneumonia was observed during the pandemic compared to the pre-pandemic period. Conclusions: In T & uuml;rkiye, the predominant causative agents of CLABSI did not change during the pandemic, with Klebsiella spp. and A. baumannii being most frequently isolated. However, the rise in CLABSI-associated mortality during the pandemic highlights the broader impact of healthcare system disruptions.
Assisting the Diagnosis of Cirrhosis in Chronic Hepatitis C Patients Based on Machine Learning Algorithms: A Novel Non-Invasive Approach
(WILEY, 2025) Dirican, Emre; Bal, Tayibe; Önlen, Yusuf; Sarıgül, Figen; Baykam, Nurcan
Aim: This study aimed to determine the important features and cut-off values after demonstrating the detectability of cirrhosis using routine laboratory test results of chronic hepatitis C (CHC) patients in machine learning (ML) algorithms. Methods: This retrospective multicenter (37 referral centers) study included the data obtained from the Hepatitis C Turkey registry of 1164 patients with biopsy-proven CHC. Three different ML algorithms were used to classify the presence/absence of cirrhosis with the determined features. Results: The highest performance in the prediction of cirrhosis (Accuracy = 0.89, AUC = 0.87) was obtained from the Random Forest (RF) method. The five most important features that contributed to the classification were platelet, alpha lpha-feto protein (AFP), age, gamma-glutamyl transferase (GGT), and prothrombin time (PT). The cut-off values of these features were obtained as platelet < 182.000/mm3, AFP > 5.49 ng/mL, age > 52 years, GGT > 39.9 U/L, and PT > 12.35 s. Using cut-off values, the risk coefficients were AOR = 4.82 for platelet, AOR = 3.49 for AFP, AOR = 4.32 for age, AOR = 3.04 for GGT, and AOR = 2.20 for PT. Conclusion: These findings indicated that the RF-based ML algorithm could classify cirrhosis with high accuracy. Thus, crucial features and cut-off values for physicians in the detection of cirrhosis were determined. In addition, although AFP is not included in non-invasive indexes, it had a remarkable contribution in predicting cirrhosis. Trial Registration: Clinicaltrials.gov identifier: NCT03145844
Renal Function and Atrial Remodeling: Interpreting Voltage-Mapping Limitations
(WILEY, 2025) Aker, Mücahit; Kalçık, Macit; Bekar, Lütfü
To the Editor, We read with interest the recent article by Deng et al., hichexplored the association between renal function and left atriallow-voltage area (LVA) burden in patients with atrial fibrillation(Deng et al. 2025).
Critical Appraisal of Circadian Blood Pressure Patterns as Predictors of Mortality in the Intensive Care Setting
(WILEY, 2025) Kalçık, Macit; Bayam, Emrah
To the Editor, We have recently, with great interest, read the recent article byZhao et al., “Association of 24-h Blood Pressure Pattern withMortality in ICU Patients: A Retrospective Cohort Study” [1].
Integrating Sleep Disruption, Dietary Changes, and Therapy in Assessing the Effects of Ramadan Fasting on Blood Pressure
(WILEY, 2025) Yetim, Mücahit; Sarıhan, Abdullah; Kalçık, Macit
Treatment and Follow-up of Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency in Childhood and Adolescence
(GALENOS PUBL HOUSE, 2025) Peltek Kendirci, Havva Nur ; Ünal, Edip; Dündar, İsmail; Buluş, Ayşe Derya; Odabaşı Güneş, Sevinç ; Sıklar, Zeynep
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disease caused by the deficiency of one of the enzymes involved in cortisol synthesis. More than 95% of the cases occur as a result of defects in the gene encoding 21-hydroxylase (CYP21A2). 21-hydroxylase deficiency has been divided into classical and non-classical forms. In the treatment of classical CAH, it is necessary to replace both glucocorticoid (GC) and mineralocorticoid hormones to prevent salt wasting crisis and reduce excessive corticotropin. In addition to biochemical measurements to evaluate the adequacy of GC and mineralocorticoid treatment; growth rate, body weight, blood pressure and physical examination should be evaluated regularly. There is insufficient data regarding the use of continuous slow-release or modified-release hydrocortisone (HC) preparations and continuous subcutaneous HC infusion, additional/alternative treatment approaches, and cell-based therapies and gene editing technology in children with CAH. GC therapy is recommended in children with inappropriately early onset and rapidly progressing pubarche or accelerated bone age progression, and in adolescents with non-classical CAH (NCCAH) who have overt virilization. In patients with NCCAH, stress doses of HC is recommended for major surgery, trauma, or childbirth but only if the patient has a suboptimal cortisol response to the adrenocorticotropic hormone test. Here, members of the 'Adrenal Working Group' of 'The Turkish Society for Pediatric Endocrinology and Diabetes' present an evidence-based review with good practice points and recommendations for optimize treatment, and follow-up of children with CAH due to 21-hydroxylase deficiency in the light of the most recent evidence.
Rapid, sensitive, and species-independent detection of Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 antibodies
(ELSEVIER, 2025) Karaaslan, E; Chiang, CF; Kurutaş, GO; Barkay, O; Güler, NSC; Kalkan, MY; Parlayan, HNK; Akdoğan, O; Çelikbaş, AK; Aksoy, F; Binay, UD; Baykam, N; Yılmaz, G; Sajadi, MM; Pegan, SD; Klena, JD; Montgomery, JM; Karakeçili, F; Kalkan, A; Doymaz, MZ; Spiropoulou, CF; Bergerona, E
Background Crimean-Congo hemorrhagic fever virus (CCHFV), a zoonotic agent in the Nairoviridae family (genus Orthonairovirus), is a high-priority pathogen. CCHFV infection causes Crimean-Congo hemorrhagic fever (CCHF), a human disease with case fatality rates of up to 40%. Serological surveillance of CCHFV in animals and humans is crucial for ecological studies and public health. Methods We developed CCHFV mix-and-read assays utilizing split-NanoLuc technology (NanoBiT) to detect anti-CCHFV antibodies against the nucleoprotein (NP) stalk region and the GP38 glycoprotein. These species-and isotypeagnostic assays provide results in similar to 30 min. Using serum samples from RT-PCR-confirmed CCHF cases collected during and after hospitalization, we investigated anti-NP and anti-GP38 antibody development. The performance of the mix-and-read assays was compared to the NP-based IDScreen (R) CCHF commercial assay using human sera, and cross-reactivity potential was evaluated using a diverse panel of anti-orthonairovirus antisera raised in mice. Findings In human convalescent cases (n = 21), mix-and-read assay concordance between anti-GP38 and anti-NP antibody detection was 100%. Both mix-and-read assays and IDScreen (R) CCHF demonstrated identical sensitivity of 95.2% in convalescent patients. The specificity of the NP assay was 98.9%, and that of GP38 was 99.7%, both comparable to IDScreen (R) CCHF (specificity: 99.7%). Cross-reactivity against CCHF NP and GP38, regardless of assay type, was primarily observed in antisera raised against other orthonairoviruses within the Nairobi sheep disease genogroup. Interpretation The simplicity and robust performance of the CCHFV mix-and-read assays make them ideal tools for supporting serological surveillance in humans and animals. Furthermore, the inclusion of the GP38 antigen alongside NP enhances the precise identification of retrospective CCHF cases, further strengthening broad surveillance efforts. Funding CDC Emerging Infectious Disease Research Core Funds, funding for reagent, CDC personal, travel. Defence Threat Reduction Agency (HDTRA12210007): E.K. salary. Oak Ridge Institute for Science and Education (ORISE): E.K. salary and travel. National Institute of Allergy and Infectious Diseases (1R01AI180125-01A1): sample acquisition. Funding sources did not have a role in the writing or decision to submit the publication. Copyright Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
Three-Decade Analysis of Inflammatory Bowel Disease in Türkiye: A Multicenter Study (1993-2024)
(AVES, 2025) Durak, MB; Çağın, YF; Balkan, A; Coşkun, Y; Karakan, T; Çağır, Y; Beyazıt, Y; Atay, A; Erdem, AC; Can, G; Altınkaya, E; Dursun, H; Coşkun, O; Ayte, MR; Hamamcı, M; Tenlik, İ; Şimşek, C; Şahin, A; Köseoğlu, H; Akar, M; Koşar, K; Albayrak, B; Karatay, E; Kekilli, M; Asil, M; Ataseven, H; Cindoruk, M; Yüksel, İ
Background/Aims: Inflammatory bowel diseases (IBDs) are increasingly prevalent and challenging globally. Data regarding IBD fre quency and severity between Europe and Asia are needed. The aim was to investigate the trend of IBD in T & uuml;rkiye during the last 3 decades. Materials and Methods: The study was conducted retrospectively at 14 centers in T & uuml;rkiye between June 1993 and March 2024. Results: Over 30 years, 4308 patients, of whom 2507 (58.2%) had ulcerative colitis (UC) and 1717 (39.9%) had Crohn's Disease (CD), were included in the study. The overall median age at the onset of IBD was 34.43 (25.28-45.64) years; the age at onset of IBD was younger in CD compared to UC (32.72 vs. 35.52 years respectively, P < .001). The peak age onset range was 28-32 years in CD, whereas 23-27 years in UC. Overall, 2526 (58.6%) patients were male. The most common location was left-sided colitis in UC patients (45.1%), followed by extensive colitis (31.2%), and proctitis (23.7%), while ileal involvement in CD patients (45.2%), afterward ileocolonic (409%), and colonic (13.5%). Both illnesses are becoming increasingly prevalent. The UC/CD ratio tends to decrease over time. During the study period, 1577 (36.6%) patients received biologic treatment. During the study period, 418 (24.3%) underwent resective surgery for CD and 88 (3.5%) total colectomy for UC; the major abdominal surgery has declined over time. Conclusion: The frequency and characteristic features of IBD in T & uuml;rkiye appear to be between Europe and Asia. Over time, while the usage of biologic therapy and the rate of CD have increased, the frequency of surgery has decreased.
Arterial Thrombosis in Patients with Primary Immune Thrombocytopenia: A Nationwide Study
(GALENOS PUBL HOUSE, 2025) Demirci, U; Ümit, EG; Dumludağ, B; Cömert, M; Çiftçiler, R; Özmen, D; Ar, MC; Güven, S; Soyer, Ö; Güney, T; Karabulut, ZT; Yıldız, A; Yaman, S; Aykaş, F; Karakuş, V; İpek, Y; Yılmaz, G; Sadri, S; Baysal, M; Uğur, MC; Pınar, İE; Demir, AM
Objective: Primary immune thrombocytopenia (pITP) is an acquired bleeding disorder involving decreased numbers of platelets due to platelet destruction or impaired production. The clinical presentation of pITP can be multifaceted and thrombotic events may rarely manifest. Thrombosis can develop with treatment or during the untreated period. The primary objective of this study was to examine the frequency of arterial thromboembolic events (ATEs) in patients with pITP. We also aimed to evaluate the risk factors in these patients and the effect of ITP treatments on ATEs. Materials and Methods: The study was designed as a retrospective multicenter study conducted under the guidance of the Turkish Society of Hematology's Scientific Subcommittee on Hemostasis-Thrombosis. Patients over the age of 18 with pITP who subsequently developed ATE while undergoing follow-up for pITP were evaluated. Results: A total of 2,178 patients with pITP were screened and 37 patients (1.7%) were observed to have developed ATE. The mean age was 62 years. Fifteen (40.5%) of the patients who developed ATEs were not receiving pITP treatment at the time of thromboembolism. Among the patients receiving pITP treatment at the time of the ATE, 9 (24.3%) were receiving eltrombopag and 10 (27%) were receiving corticosteroids. Compared to patients who did not develop ATEs, multivariate analysis revealed that the presence of hypertension, comorbidity, and history of venous thromboembolism statistically significantly increased the risk of developing ATEs (p=0.008, p=0.018, and p=0.038, respectively). Conclusion: The risk of ATEs may increase in pITP patients both during and without treatment. It is important to inquire thoroughly about the presence of comorbidities, atherosclerotic risk factors, hypertension, and history of thrombosis in these patients at the initiation of treatment. Correctable risk factors should be addressed to minimize the number of risk factors present. The treatment of pITP must be individualized, including consideration of age-related disorders.
Structural and Magnetic Characterization, Biomedical Applications, and Hyperfine Interactions of Quaternary Nanospinel Ferrites
(AMER CHEMICAL SOC, 2025) Aljameel, Suhailah S.; Baykal, Abdulhadi; Almessiere, Munirah Abdullah; Rehman, Suriya; Çalışkan, Serkan; Khan, Firdos Alam; Amir, Md; Shirsath, Sagar Eknathrao; Güngüneş, Hakan; Slimani, Yassine
In this study, the following, Co0.25Ni0.25Mn0.25Zn0.25Fe2O4 (CoNiMnZn), Co0.25Ni0.25Mn0.25Cu0.25Fe2O4 (CoNiMnCu), Co0.25Ni0.25Zn0.25Cu0.25Fe2O4 (CoNiZnCu), Co0.25Mn0.25Zn0.25Cu0.25Fe2O4 (CoMnZnCu), and Ni0.25Mn0.25Zn0.25Cu0.25Fe2O4 (NiMnZnCu), nano spinel ferrites (NSFs) have been synthesized via a sol-gel auto combustion route. Their XRD analysis confirmed the formation of cubic crystalline nanoproducts without any impurity. The crystallite size of the products varied between 15 and 26 nm. EDX analysis confirmed the chemical composition of each product. According to Mossbauer results, Zn2+ ions occupy A sites. The s-electron density of Fe3+ ions at the A and B sites increased with the Zn2+ doping. The magnetic features of samples with various combinations of Co, Ni, Cu, Mn, and Zn were systematically investigated at room temperature (RT, 300 K) and 10 K. Key magnetic parameters M s (saturation magnetization), M r (remanent magnetization), H c (coercivity), squareness ratio, magnetic moment, and magnetocrystalline anisotropy field) are extracted to elucidate the influence of cationic doping and temperature on their magnetic response. Among all samples, CoNiMnCu displayed the highest magnetic hardness and anisotropy, while NiMnZnCu NSFs exhibited soft magnetic behavior with high M s and low H c. The results demonstrate significant improvements in magnetic ordering and anisotropy at 10 K across all samples, revealing the temperature-driven enhancement of ferrimagnetic coupling. These findings highlight the tunability of magnetic performance through cation engineering and provide guidance for designing spinel ferrites tailored to specific technological applications, such as permanent magnets, sensors, and magnetic devices. The breast cancer cell (MCF-7) biomedical application of all samples showed a significant decrease in cancer cells as revealed by the MTT assay. Among all samples, CoNiZnCu NSFs showed the highest anticancer activities, as the cell viability was 57.95%. We have also examined the treatment of NSFs on HEK-293, and we detected a reduction in cancer cell viability. However, treatment of NSFs showed more cytotoxicity to breast cancer cells than normal cells. The cells were also stained with DAPI staining. The treatment of CoNiZnCu NSFs produced significant cytotoxicity in breast cancer cells. Moreover, CoNiZnCu NSFs induced chromatin abridgment and apoptotic bodies' formation in the cancer cells. The antimicrobial potential of synthesized metal-based compounds was investigated against Enterococcus faecalis and Candida albicans. Five NSFs were tested at a 16 mg/mL concentration using the broth dilution method. E. faecalis showed strong susceptibility to all compounds except CoNiMnZn NSFs. C. albicans exhibited mild resistance, with only CoMnZnCu NSFs showing notable antifungal activity. The findings highlighted selective and promising antimicrobial effects based on the microbial structure.
Effect of histidine and carnosine on haemoglobin recovery in anaemia induced-kidney damage and iron-loading mouse models
(SPRINGER WIEN, 2025) Vera-Aviles, Mayra; Moreno-Fernandez, Jorge; Köse, Tuğba; Hider, Robert ; Latunde-Dada, Gladys O.
Histidine and carnosine can form complexes with divalent metal ions such as Fe2+, potentially providing stability to intracellular labile iron. Anaemia is a common comorbidity in the late stages of kidney disease, and patients are treated with erythropoiesis-stimulating agents (ESAs) and iron supplementation. However, iron supplementation is also associated with worse long-term outcomes. The purpose of this study is to investigate how histidine and carnosine supplementation can reduce symptoms of anaemia of chronic kidney disease (CKD) and the effects associated with iron-overloaded conditions. Adenine-induced chronic kidney disease mice were treated with histidine and carnosine by oral gavage for 10 days. Additionally, a model involving iron overload in mice was established, and these mice received concurrent treatment with histidine and carnosine. Haemoglobin, non-haem iron, malondialdehyde (MDA) and iron parameters were measured. Carnosine increased erythropoietin (EPO) levels (35.62 mu g/ml +/- 11.43) and resulted in haemoglobin repletion (16.7 g/dL +/- 3.4). When iron was supplemented alongside with histidine or carnosine, there were better effects on haemoglobin repletion (14.22 +/- 1.7 and 13.82 +/- 2.15 g/ dL respectively), ferritin (59.5 +/- 16.4, 52 +/- 29.5 mu g/ml) and non-haem iron (0.8 +/- 0.21, 0.7 +/- 0.38 nmol/mg), than the group receiving iron alone (p < 0.05). Furthermore, histidine and carnosine reduced non-haem iron and MDA, in iron-loaded conditions (p < 0.05). These positive effects observed in histidine and carnosine could be associated with reactive oxygen species (ROS) scavenging. EPO restoring levels in CKD model and the increment in haemoglobin and ferritin in carnosine treatments suggested the potential formation of a ternary complex with iron-glutathione. In conclusion, our results indicate the beneficial effect of histidine and carnosine in the context of iron supplementation for the correction of haemoglobin and protection against iron-loaded conditions.
Therapeutic Effects of tDCS on Calcium and Glutamate Excitotoxicity in a Cerebral Ischemia-Reperfusion Rat Model
(TURKISH NEUROSURGICAL SOC, 2025) Akçay, Güven; Demirdöğen, Filiz; Kotan, Dilcan; Gül, Tuba; Yılmaz, Ali; Ergül, Yusuf Müslüm; Çelik, Çağla
AIM: To investigate the therapeutic effects of transcranial direct current stimulation (tDCS) on calcium and glutamate excitotoxicity caused by ischemia-reperfusion (IR). MATERIAL and METHODS: The IR model was generated by transient middle cerebral artery occlusion. tDCS treatment was applied at 1 mA for 30 min daily at the 2nd, 24th, and 48th h of IR. The motor and cognitive functions and the concentrations of Ca2+, glutamate, and N-methyl-D-aspartate receptor (NMDAR) in the hippocampus tissues were evaluated. RESULTS: Results showed a reduction in motor and cognitive functions in the IR group compared with that in the sham group, whereas these functions increased in the IR+tDCS group compared with those in the IR group. Ca2+, glutamate, and NMDAR concentrations were higher in the IR group than in the sham group but lower in the IR+tDCS group than in the IR group. CONCLUSION: These results suggest that tDCS treatment improves motor and cognitive dysfunctions after IR and exerts therapeutic effects on learning and memory through the regulation of Ca2+ and glutamate excitotoxicity.
Assessing Dexmedetomidin's Efficacy in Traumatic Brain Injury Treatment Using a Rat Experimental Model
(TURKISH NEUROSURGICAL SOC, 2025) Öztürk, Yaşar; Bozkurt, İsmail; Mammadkhanli, Orkhan; Güvenç, Yahya; Şentürk, Salim; Güney, Güven; Ramírez, Manuel De Jesus Encarnación; Gülbahar, Özlem
AIM: To elucidate the effects of nasal and intraperitoneal dexmedetomidine (DexN and DexP, respectively) administration in an animal model, and to explore the underlying action mechanisms on the treatment of traumatic brain injury (TBI). MATERIAL and METHODS: A total of 31 Wistar albino rats served as a weight-drop model to induce experimental TBI. The two treatment groups received DexN and DexP on the day of the trauma and then after 5 days. The Garcia test was performed for the neurological evaluation along with histopathological and biochemical analyses. RESULTS: The rats in the treatment group displayed better neurological outcomes, as evidenced by a higher Garcia test score (p<0.001). DexP group presented with increased anti-inflammatory and neuroprotective effects in comparison to DexN (p<0.001). DexN group demonstrated a reduction in the neuron specific enolase (NSE) levels (p=0.023), indicating that it inhibited the neuronal destruction. CONCLUSION: The present study support the hypothesis that a psychoactive drug, Dex, which has been conventionally used for sleep disorders and is also known for its cognitive-enhancing properties, may have beneficial effects after TBI owing to its antiinflammatory, anti-oxidative, and neuroprotective properties.
Impact of an 8-week high-intensity bodyweight interval training on body composition and blood lipid metabolism in young women with overweight
(FRONTIERS MEDIA SA, 2025) Yamaner, Emre; Turgut, Tuna; Aksoy, Ayşe; Demirkıran, Burhan; Çamiçi, Furkan; Ceylan, Levent
Background A physically inactive lifestyle is associated with an increased risk of obesity, dyslipidemia and metabolic disorders, especially in women. While high-intensity training methods have been extensively studied in male populations, the physiological and metabolic effects of high-intensity interval resistance training (HIIRT) in overweight women are understudied. The aim of this study was to investigate the effects of an 8-week HIIRT program on body composition and lipid metabolism in women.Methods A total of 30 women (mean age: 23.13 +/- 4.03 years, mean BMI: 31.21 +/- 2.92 kg/m2) participated in an 8-week HIIRT program. Body composition was measured before and after the intervention using bioelectrical impedance analysis (BIA), while blood lipid parameters (triglycerides, total cholesterol, LDL, and HDL) were analyzed. Paired-sample t-tests were performed to determine the significance of the changes in body composition and lipid metabolism, using Cohen's d effect size for interpretation.Results The HIIRT program led to significant improvements in body composition, with body weight decreasing by 11.4 kg (p = 0.001, d = 0.96) and fat percentage decreasing by 3.1% (p = 0.001, d = 0.92). In addition, blood lipid profiles improved significantly, with triglycerides (-8.9 mg/dL, p = 0.001, d = 0.81, medium effect), total cholesterol (-19.7 mg/dL, p = 0,020, d = 1.98, large effect), and LDL (-8.2 mg/dL, p = 0.004, d = 1.96, large effect) decreased, while HDL increased by +10 mg/dL (p = 0.006, d >= 2.0, very large effect). These results underline the positive effects of HIIRT on lipid metabolism and cardiovascular health.Conclusion The results suggest that HIIRT is an effective and time-efficient training model for improving body composition and metabolic health in women. The combination of high-intensity interval training principles with resistance exercise optimizes fat oxidation, improves fat metabolism and supports cardiovascular function. Given its efficacy, HIIRT could be a valuable strategy for treating metabolic disorders and reducing the risks of physically inactive behavior. Future research should focus on long-term adaptations and individual variability in metabolic responses to optimize HIIRT programs for broader populations.

Güncel Gönderiler