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    Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation
    (Humana Press Inc., 2016) Ateş, İhsan; Kaplan, Mustafa; Yüksel, Mahmut; Meşe, Duygu; Alışık, Murat; Erel, Özcan; Yılmaz, Nisbet; Güler, Serdar
    In this study, we aimed to examine dynamic thiol/disulfide homeostasis in type 1 diabetes mellitus (T1DM) and identify the factors associated with thiol oxidation. Thirty-eight subjects (18 male, 20 female) diagnosed with T1DM and 38 (17 male, 21 female) healthy volunteers without any known diseases were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method (Erel & Neselioglu) in this study. After native thiol, total thiol and disulfide levels were determined; measures such as disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated. In T1DM patients, compared to the control group, disulfide (p = 0.024), disulfide/native thiol (p < 0.001), and disulfide/total thiol (p < 0.001) were determined higher, while native thiol (p = 0.004) and total thiol (p < 0.001) levels were much lower. In the patient group, a positive correlation was determined between c-reactive protein (r = 325, p = 0.007; r = 316, p = 0.010, respectively), fasting blood glucose (r = 279, p = 0.018; r = 251, p = 0.035, respectively), and glycosylated hemoglobin (r = 341, p = 0.004; r = 332, p = 0.005, respectively) and rates of disulfide/native thiol and disulfide/total thiol. We determined that thiol oxidation increase in T1DM patients compared to the control group. We thought that hyperglycemia and chronic inflammation might be the major cause of increase in oxide thiol form. In order to determine the relationship between the status of autoimmunity and dynamic thiol/disulfide in T1DM, dynamic thiol/disulfide homeostasis in newly diagnosed-antibody positive-T1DM patients is required to be investigated. © 2015, Springer Science+Business Media New York.
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    Ischemia-modified albumin as a possible marker of oxidative stress in patients with telogen effluvium
    (Elsevier Science Inc, 2020) Savcı, Ünsal; Şenel, Engin; Öztekin, Aynure; Sungur, Mustafa; Erel, Özcan; Neşelioğlu, Salim
    Background: Telogen effluvium is the most common form of non-scarring alopecia characterized by diffuse hair loss. Ischemia-modified albumin is a marker of oxidative stress and inflammation. Objective: The aim of this study was to compare the levels of ischemia-modified albumin of telogen effluvium patients with healthy controls. Methods: Ninety-one patients diagnosed with telogen effluvium and 35 healthy volunteers were included in the study. Serum ischemia-modified albumin level was determined by a fast-colorimetric method, and albumin cobalt binding test. The results were evaluated statistically. Results: There was no statistically significant difference between the serum albumin values of patient and control groups (p = 0.739). Serum ischemia-modified albumin values were significantly higher in the patients with telogen effluvium than healthy controls (p < 0.001). Study limitations: Body mass index values of the patient and control groups could not be calculated. Conclusions: To the best of the authors' knowledge, this is the first clinical study to investigate the role of oxidative stress in the pathogenesis of telogen effluvium using ischemia-modified albumin as a biomarker. Based on the results of the present study, it can be considered that oxidative stress plays an important role in the pathogenesis of telogen effluvium. There is a need for further studies to support the results of this study, to demonstrate the possible effects of oxidative stress, and to investigate the other oxidative stress markers in the pathogenesis of telogen effluvium. (C) 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.
  • Küçük Resim
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    Liken planusda oksidatif stres parametreleri ve dislipideminin oksidatif stres parametreleri üzerine etkisi
    (Galenos Yayınevi, 2015) Kılıç, Arzu; Erdoğan, Serpil; Yorulmaz, Ahu; Doğan, Sibel; Ergin, Merve; Artüz, Refika Ferda; Erel, Özcan
    Amaç: Çeşitli çalışmalar enflamatuvar deri hastalıkları ve oksidatif stres arasında bir ilişki saptamışlardır. Ayrıca, dislipidemi ve çeşitli sistemik hastalıklar da kronik enflamatuvar deri hastalıkları ile ilişkili bulunmuştur. Bu çalışmada, liken planusda (LP) oksidatif stres parametrelerini ve dislipideminin oksidatif stres parametreleri üzerine olan etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya 54 LP'li ve 60 sağlıklı kontrol grubu alındı. Tüm katılımcılardan serum total kolesterol (TK), trigliserid, yüksekdansiteli lipoprotein kolesterol ‘high density lipoprotein cholesterol’ (HDL-C), düşük-dansiteli lipoprotein kolesterol ‘low density lipoprotein cholesterol’ (LDL-C), çok düşük dansiteli lipoprotein kolesterol ‘very low density lipoproteins cholesterol’ (VLDL-C) çalışıldı. Eşlik eden sistemik hastalıklar ekarte edildiğinde kalan 36 LP’li hasta ve kontrol grubunda total antioksidan status (TAS), paraoksonaz (PON), stimüle PON, arilesteraz, total serum tiyol (TTL) çalışıldı. Bulgular: Hasta grubunun %62,96'sında dislipidemi saptandı. TK ve LDL-C düzeyleri kontrol grubuna göre hasta grubunda istatistiksel olarak anlamlı olarak yüksek ve HDL-C düzeyleri kontrol grubuna göre hasta grubunda anlamlı olarak düşük bulundu. Serum TAS değerleri hasta grubunda kontrol grubuna göre anlamlı olarak düşük saptandı. Dislipidemi eşlik eden ve etmeyen LP’li hastalar oksidatif stres parametreleri açısından karşılaştırıldığında dislipidemisi olanlarda TTL düzeyleri anlamlı olarak düşük bulundu. Sonuç: Bu çalışmada LP, dislipidemi ile ilişkili bulunmuştur. Ayrıca bulgularımız azalmış TAS aktivitesinin LP patogenezinde rolünün olabileceğini desteklemektedir. Bulgularımız dislipideminin vücudun antioksidan savunma mekanizmasını zayıflatarak LP etiyopatogenezine katkıda bulunabileceği düşündürmektedir. LP ile başvuran hastalarda dislipideminin hastalığın sıklığı, mekanizmasına ve şiddetine muhtemel etkilerinin aydınlatılabilmesi için geniş kapsamlı, prospektif çalışmalara ihtiyaç vardır.
  • Küçük Resim
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    The relationship between severity of ulcerative colitis and thiol-disulphide homeostasis
    (Comenius University, 2018) Neşelioğlu, Salim; Keşke, P. B.; Senat, Aydın A.; Tayfur Yürekli, Öykü; Erdoğan, S. Ayça; Alışık, Murat; Ergin, Merve; Köseoğlu, Hüseyin; Ersoy, Özlem; Erel, Özcan
    OBJECTIVES: The aim of the study was to determine dynamic thiol-disulphide homeostasis in patients with ulcerative colitis, compare it with those of healthy control and to investigate the relationship between the severity of the disease and homeostasis METHODS: A total of 78 patients and 58 healthy subjects were included in the study. Serum native thiol, total thiol and disulphide amounts were measured by using a novel automated method. Obtained results were compared and relationships were determined by correlation analysis. RESULTS: Serum native thiol, total thiol, disulphide amounts and disulphide/native thiol percent ratio (index) were significantly lower (p = 0.003 for index ratio and p < 0.001 for other parameters) in patients with ulcerative colitis than in healthy controls. Native thiol, total thiol and disulphide amounts were significantly higher (p < 0.001) in patients with ulcerative colitis in remission than in patients with active ulcerative colitis and near to those of healthy control. There were significant negative correlations between the severity of the disease and thiol-disulphide homeostasis parameters (r = -0.55, p < 0.001 for native thiol; r = -0.64, p < 0.0001 for total thiol; r = -0.65, p < 0.001 for disulphide and r = -0.33, p = 0.011 for index). CONCLUSION: The thiol-disulphide homeostasis was weakened in ulcerative colitis. Strong correlations between the activity of the disease and thiol-disulfide homeostasis indicate that homeostasis may play a role in the pathogenesis of the disease. © 2018, Comenius University.
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    Thiol-disulfide homeostasis in children with celiac disease
    (Wiley, 2020) Comba, Atakan; Güreser, Ayşe Semra; Karasartova, Djursun; Senat, Almila; Erel, Özcan; Taylan Özkan, Hikmet Ayşegül
    Background Toxic gliadin peptide damages enterocytes in celiac disease by causing oxidative stress. Thiols are organic compounds that defend against oxidative stress. This study aimed to investigate the changes in thiol-disulfide homeostasis in children with celiac disease. Methods The study included patients with celiac disease, children diagnosed with functional gastrointestinal disorders, and healthy children. Patients' serum native and total thiol-disulfide amounts, disulfide/total thiol percentage ratios, disulfide / native thiol percentage ratios, and native thiol/total thiol percentage ratios were measured. Results The study involved 172 children, of whom 90 (52.3%) were girls. The mean participant age was 8.6 +/- 4.2 years. A total of 59 (34.3%) children had celiac disease, 56 (32.6%) had functional gastrointestinal disorders, and 57 (33.1%) were healthy. The total thiol and disulfide levels of patients with celiac disease (305 +/- 87 mu mol/L and 25 +/- 15 mu mol/L, respectively) were significantly lower than those of healthy children (349 +/- 82 mu mol/L and 40 +/- 15 mu mol/L, respectively) (P= 0.006 andP <0.001, respectively). Native and total thiol levels (226 +/- 85 mu mol/L and 279 +/- 99 mu mol/L, respectively) in patients with celiac disease who consumed a gluten-containing diet were significantly lower than those of patients who consumed a gluten-free diet (278 +/- 64 mu mol/L and 327 +/- 69 mu mol/L, respectively) (P= 0.017 andP= 0.041, respectively). Conclusions Thiol-disulfide homeostasis, an important antioxidant defense component of the gastrointestinal system, is disrupted in children with celiac disease. A gluten-free diet helped partially ameliorate this decline.
  • Küçük Resim
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    Thiol/disulfide homeostasis in patients with telogen effluvium: is oxidative stress important in the pathogenesis of telogen effluvium?
    (Wolters Kluwer ? Medknow, 2019) Savcı, Ünsal; Şahin, Mustafa; Şenel, Engin; Öztekin, Aynure; Muslu, Ümran; Sungur, Mustafa; Neşelioğlu, Salim; Erel, Özcan
    Objective: The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE. Methods: Our study included 101 patients with TE diagnosis and 39 healthy individuals. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: Among the six thiol/disulfide parameters, there were statistically significant differences for native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol studied in the patient and control groups (P = 0.042, 0.044, < 0.001, respectively). Conclusions: Based on the results of this study, it can be said that OS is closely associated with TE pathogenesis. There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.