The relationship between severity of ulcerative colitis and thiol-disulphide homeostasis
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Comenius University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVES: The aim of the study was to determine dynamic thiol-disulphide homeostasis in patients with ulcerative colitis, compare it with those of healthy control and to investigate the relationship between the severity of the disease and homeostasis METHODS: A total of 78 patients and 58 healthy subjects were included in the study. Serum native thiol, total thiol and disulphide amounts were measured by using a novel automated method. Obtained results were compared and relationships were determined by correlation analysis. RESULTS: Serum native thiol, total thiol, disulphide amounts and disulphide/native thiol percent ratio (index) were significantly lower (p = 0.003 for index ratio and p < 0.001 for other parameters) in patients with ulcerative colitis than in healthy controls. Native thiol, total thiol and disulphide amounts were significantly higher (p < 0.001) in patients with ulcerative colitis in remission than in patients with active ulcerative colitis and near to those of healthy control. There were significant negative correlations between the severity of the disease and thiol-disulphide homeostasis parameters (r = -0.55, p < 0.001 for native thiol; r = -0.64, p < 0.0001 for total thiol; r = -0.65, p < 0.001 for disulphide and r = -0.33, p = 0.011 for index). CONCLUSION: The thiol-disulphide homeostasis was weakened in ulcerative colitis. Strong correlations between the activity of the disease and thiol-disulfide homeostasis indicate that homeostasis may play a role in the pathogenesis of the disease. © 2018, Comenius University.
Açıklama
Anahtar Kelimeler
Disulphide, Inflammatory Bowel Disease, Thiol, Ulcerative Colitis
Kaynak
Bratislava Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
119
Sayı
8
Künye
Neşelioğlu, S., Keske, P.B., Senat, A.A., Yurekli, O.T., Erdogan, S.A., Alisik, M., Ergin, M., Koseoglu, H., Ersoy, O., & Erel, O. (2018). The relationship between severity of ulcerative colitis and thiol-disulphide homeostasis. Bratislavske lekarske listy, 119(8), 498-502 .
