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Öğe Antimicrobial activity and chemical composition of coriander & galangal essential oil(Association of Pharmaceutical Teachers of India, 2017) Özkınalı, Sevil; Şener, Nesrin; Gür, Mahmut; Güney, Kerim; Olgun, ÇağrıEssential oils were obtained from Coriandrum sativum and Alpinia officinarum through steam distillation method in this study. Antimicrobial activities of the obtained essential oils were investigated by using minimum inhibitory concentration (MIC) test by against 18 different species microorganisms. It was found that the C. sativum had strong antimicrobial activities against the 14 tested microorganism and A. officinarum oils showed strong antimicrobial activity against the 7 tested microorganisms. Furthermore, the contents of the essential oils were determined with GC-MS analyses. The most abundant compounds of essential oils of A. officinarum and C. sativum were determined as 28.4% eucalyptol and 69.4% linalool. As a result, it can be easily said that the essential oils of C. sativum and A. officinarum can be used as antimicrobial protector in related fields. © 2017, Association of Pharmaceutical Teachers of India. All rights reserved.Öğe Determination of antimicrobial activity and chemical composition of pimento & ginger essential oil(Association of Pharmaceutical Teachers of India, 2017) Şener, Nesrin; Özkınalı, Sevil; Gür, Mahmut; Güney, Kerim; Özkan, Osman Emre; Khalifa, Moustafa MiladThe essential oil was obtained from pimento (Pimenta racemosa Mill.) and ginger (Zingiber officinale Rosc.) through hydrodistillation method. The chemical composition of pimento and ginger essential oils were analyzed by GC-MS. It was found that the most abundant components were methyleugenol (52.33%) and zingiberene (16.32%) in essential oils of pimento and ginger, respectively. The antimicrobial activities of essential oils were investigated against 18 microorganisms with minimum inhibitory concentration (MIC) method. While pimento essential oil behaved strong antimicrobial against all bacteria apart from S. epidermidis, ginger essential oil exhibited poor activity against all bacteria. As a result of this study; it can be suggested that pimento essential oil is a preservative in the medicinal application and food industry. © 2017, Association of Pharmaceutical Teachers of India. All rights reserved.Öğe Structural, absorption, and molecular properties of o,o'-dihydroxyazo resorcinol dyes bearing an acryloyloxy group(Elsevier B.V., 2017) Özkınalı, Sevil; Çavuş, Muhammet Serdar; Ceylan, Abdullah; Gür, MahmutTo the best of our knowledge, this is the first study reporting the synthesis and characterization of o,o?-dihydroxyazo dyes bearing an acryloyl group. The o,o?-dihydroxyazo dyes were synthesized through coupling of resorcinol with the diazonium salts of 2-amino-4-methylphenol, 2-aminophenol, 2-amino-4-chlorophenol, and 2-amino-4-nitrophenol. Their acryloyl derivatives were synthesized using metallic sodium and acryloyl chloride under an inert atmosphere. Characterization of the compounds was conducted using infrared (IR), ultraviolet–visible (UV–vis), proton nuclear magnetic resonance (1H NMR), and carbon nuclear magnetic resonance (13C NMR) spectroscopic methods. The tautomerism of the synthesized compounds' was also evaluated. The results were compared with theoretical results obtained by density functional theory (DFT). The DFT calculations were performed to obtain ground-state optimized geometries and calculate the relevant electronic and chemical reactivity parameters. Furthermore, possible tautomers deduced from the UV–vis spectra were investigated using theoretical calculations. Both the IR and NMR spectral data showed that azo tautomers predominate in the solid state and DMSO solvent. The effects of pH, solvent, and substituent on the predominant tautomers were further investigated through UV–vis spectroscopy. The results indicate that hydrazone tautomers were dominant at pH 12 in dimethylformamide (DMF), whereas azo tautomers were dominant at pH 2 in EtOH or CHCl3. © 2017 Elsevier B.V.Öğe Synthesis and characterization of 1,3,4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities(Elsevier B.V., 2018) Muğlu, Halit; Şener, Nesrin; Mohammad Emsaed, Hamza Ahmet; Özkınalı, Sevil; Özkan, Osman Emre; Gür, MahmutNew 1,3,4-thiadiazole compounds were synthesized through the cyclization reaction of 4-phenoxybutyric acid and N-phenylthiosemicarbazide derivatives with phosphorous oxychloride. The structures of 1,3,4-thiadiazole compounds (I–XII) were clarified using spectroscopic methods such as FT-IR, 1H NMR, and 13C NMR. Moreover, their antibacterial activities were tested against gram negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, Escherichia coli) and gram positive bacteria (Staphylococcus aureus, Bacillus subtilis, Enterococcus durans) using a disk diffusion method. An antifungal activity experiment was further carried out against Candida albicans using the disk diffusion method. While these compounds presented antibacterial activity against S. aureus, they did not show antimicrobial activity against gram negative (E. coli, E. aerogenes, S. kentucky, S. enteritidis, S. typhimurium, S. infantis) and gram positive (B. subtilis) bacteria, and the fungi C. albicans. © 2018 Elsevier B.V.Öğe Synthesis of new azo schiff bases of pyrazole derivatives and their spectroscopic and theoretical investigations(Elsevier B.V., 2018) Özkınalı, Sevil; Gür, Mahmut; Şener, Nesrin; Alkın, Satı; Çavuş, Muhammet SerdarNew pyrazole Schiff bases containing azo groups, 4-((E)-phenyldiazenyl)-3-(4-nitrobenzylidene)-1-phenyl-pyrazole-5-amine and its series, were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-1-phenyl-4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine in the molar ratio of 1:1. The compounds were characterized using IR, UV–Vis, 1H-NMR and 13C-NMR spectroscopies. The UV–Vis spectral data were obtained in ethanol, chloroform, N,N-dimethylformamide (DMF), DMF (pH = 2) and DMF (pH = 12), which have different polarity and pH values. Meanwhile, the experimental spectral analyses were supported by the theoretical calculations based on the density functional theory (DFT) using the B3LYP/cc-pvtz level. Structural analyses, vibrational frequencies, UV, and NMR calculations were performed at the same level of the theory. In addition, via using HOMO-LUMO energies, the electrochemical quantities such as chemical hardness and electronegativity were calculated and analyzed. © 2018 Elsevier B.V.
