Synthesis and characterization of 1,3,4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
New 1,3,4-thiadiazole compounds were synthesized through the cyclization reaction of 4-phenoxybutyric acid and N-phenylthiosemicarbazide derivatives with phosphorous oxychloride. The structures of 1,3,4-thiadiazole compounds (I–XII) were clarified using spectroscopic methods such as FT-IR, 1H NMR, and 13C NMR. Moreover, their antibacterial activities were tested against gram negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, Escherichia coli) and gram positive bacteria (Staphylococcus aureus, Bacillus subtilis, Enterococcus durans) using a disk diffusion method. An antifungal activity experiment was further carried out against Candida albicans using the disk diffusion method. While these compounds presented antibacterial activity against S. aureus, they did not show antimicrobial activity against gram negative (E. coli, E. aerogenes, S. kentucky, S. enteritidis, S. typhimurium, S. infantis) and gram positive (B. subtilis) bacteria, and the fungi C. albicans. © 2018 Elsevier B.V.
Açıklama
Anahtar Kelimeler
1,3,4-Thiadiazole, Antimicrobial Activity, IR and NMR Spectroscopies
Kaynak
Journal of Molecular Structure
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
1174
Sayı
Künye
Muğlu, H., Şener, N., Emsaed, H. A. M., Özkınalı, S., Özkan, O. E., & Gür, M. (2018). Synthesis and characterization of 1, 3, 4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities. Journal of Molecular Structure, 1174, 151-159.
