Synthesis and characterization of 1,3,4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities

Basit Öğe Kaydı
dc.contributor.authorMuğlu, Halit
dc.contributor.authorŞener, Nesrin
dc.contributor.authorMohammad Emsaed, Hamza Ahmet
dc.contributor.authorÖzkınalı, Sevil
dc.contributor.authorÖzkan, Osman Emre
dc.contributor.authorGür, Mahmut
dc.date.accessioned2019-05-10T09:38:59Z
dc.date.available2019-05-10T09:38:59Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractNew 1,3,4-thiadiazole compounds were synthesized through the cyclization reaction of 4-phenoxybutyric acid and N-phenylthiosemicarbazide derivatives with phosphorous oxychloride. The structures of 1,3,4-thiadiazole compounds (I–XII) were clarified using spectroscopic methods such as FT-IR, 1H NMR, and 13C NMR. Moreover, their antibacterial activities were tested against gram negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, Escherichia coli) and gram positive bacteria (Staphylococcus aureus, Bacillus subtilis, Enterococcus durans) using a disk diffusion method. An antifungal activity experiment was further carried out against Candida albicans using the disk diffusion method. While these compounds presented antibacterial activity against S. aureus, they did not show antimicrobial activity against gram negative (E. coli, E. aerogenes, S. kentucky, S. enteritidis, S. typhimurium, S. infantis) and gram positive (B. subtilis) bacteria, and the fungi C. albicans. © 2018 Elsevier B.V.
dc.identifier.citationMuğlu, H., Şener, N., Emsaed, H. A. M., Özkınalı, S., Özkan, O. E., & Gür, M. (2018). Synthesis and characterization of 1, 3, 4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities. Journal of Molecular Structure, 1174, 151-159.
dc.identifier.doi10.1016/j.molstruc.2018.03.116
dc.identifier.endpage159en_US
dc.identifier.issn0022-2860
dc.identifier.scopusqualityQ1
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2018.03.116
dc.identifier.urihttps://hdl.handle.net/11491/573
dc.identifier.volume1174en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject1,3,4-Thiadiazoleen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectIR and NMR Spectroscopiesen_US
dc.titleSynthesis and characterization of 1,3,4-thiadiazole compounds derived from 4-phenoxybutyric acid for antimicrobial activities
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu