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Öğe Associations between Gilbert's syndrome and personality characteristics(Assoc Psiquiatria Rio Grande Sul, 2021) Düzenli, Tolga; Maden, Özgür; Tanoğlu, Alpaslan; Kaplan, Mustafa; Yazgan, YusufObjective: Gilbert's syndrome (GS) is a benign genetic disorder that is characterized by intermittent mild jaundice in which the liver doesn't process bilirubin properly. The aim of this study was to determine whether GS patients have a different personality structure and if there are associations between properties of temperament and character and total bilirubin levels. Methods: A total of 1665 young male individuals aged from 19 to 30 who were admitted for occupational examinations were included in this study. Careful patient history was taken, a detailed physical examination was conducted, and hematologic and biochemical tests and abdominal ultrasonography were performed. The Turkish version of the Temperament and Character Inventory (TCI) was administered to all participants. 81 patients diagnosed with GS and 150 randomly chosen healthy individuals (control group) were investigated with comparison and correlation analyses. Results: GS patients had higher scores than healthy controls for disorderliness (NS4) (p = 0.018), sentimentality (RD1) (p = 0.042), and fatigability (HA4) (p = 0.03). Moreover, Gilbert syndrome patients scored lower than controls for empathy (C2) (p = 0.041) and transpersonal identification (ST2) (p = 0.044). Bilirubin levels were positively associated with disorderliness (NS4) (r = 0.141, p = 0.032) and fatigability (HA4) (r = 0.14, p = 0.033). Conclusions: GS patients may have some different personality characteristics from healthy individuals. This study is an initial exploration of the personality structure of GS patients and the findings should be interpreted with caution. Further prospective studies are needed to identify the relationship between Gilbert disease and personality characteristics.Öğe Determination of thiol/disulphide homeostasis in type 1 diabetes mellitus and the factors associated with thiol oxidation(Humana Press Inc., 2016) Ateş, İhsan; Kaplan, Mustafa; Yüksel, Mahmut; Meşe, Duygu; Alışık, Murat; Erel, Özcan; Yılmaz, Nisbet; Güler, SerdarIn this study, we aimed to examine dynamic thiol/disulfide homeostasis in type 1 diabetes mellitus (T1DM) and identify the factors associated with thiol oxidation. Thirty-eight subjects (18 male, 20 female) diagnosed with T1DM and 38 (17 male, 21 female) healthy volunteers without any known diseases were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method (Erel & Neselioglu) in this study. After native thiol, total thiol and disulfide levels were determined; measures such as disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated. In T1DM patients, compared to the control group, disulfide (p = 0.024), disulfide/native thiol (p < 0.001), and disulfide/total thiol (p < 0.001) were determined higher, while native thiol (p = 0.004) and total thiol (p < 0.001) levels were much lower. In the patient group, a positive correlation was determined between c-reactive protein (r = 325, p = 0.007; r = 316, p = 0.010, respectively), fasting blood glucose (r = 279, p = 0.018; r = 251, p = 0.035, respectively), and glycosylated hemoglobin (r = 341, p = 0.004; r = 332, p = 0.005, respectively) and rates of disulfide/native thiol and disulfide/total thiol. We determined that thiol oxidation increase in T1DM patients compared to the control group. We thought that hyperglycemia and chronic inflammation might be the major cause of increase in oxide thiol form. In order to determine the relationship between the status of autoimmunity and dynamic thiol/disulfide in T1DM, dynamic thiol/disulfide homeostasis in newly diagnosed-antibody positive-T1DM patients is required to be investigated. © 2015, Springer Science+Business Media New York.Öğe Factors associated with increased irisin levels in the type 1 diabetes mellitus(De Gruyter Open Ltd, 2017) Ateş, İhsan; Arıkan, Mehmet Fettah; Erdoğan, Kübra; Kaplan, Mustafa; Yüksel, Mahmut; Topçuoğlu, Canan; Yılmaz, Nisbet; Güler, SerdarObjective. The aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of irisin levels with the inflammation and autoimmunity. Methods. This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient files. Serum irisin levels were measured by ELISA kit. Results. The median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p<0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021). In multivariate regression model, HbA1c (B±SE: 2.76±17683, p<0.001), and anti-GAD (B±SE: 2.311±0.610, p=0.001) were determined as independent predictors for predicting the irisin levels. Conclusion. In patients with T1DM, which chronic inflammation and autoimmunity take part in their etiopathogenesis, anti-GAD levels were an independent risk factor for the irisin. This may suggest that factors such as inflammation and autoimmunity can be effective in the synthesis of irisin. © 2017, De Gruyter Open Ltd. All rights reserved.Öğe Gilbert Sendromunun Hematolojik Parametreler üzerine etkisi var mı?(Gazi Üniversitesi, 2020) Düzenli, Tolga; Çakır Güney, Başak; Tanoğlu, Alpaslan; Kaplan, Mustafa; Akyol, TanerAmaç: Gilbert sendromu, artmış indirek bilirubin düzeyleri ile karakterize, tekrarlayan hafif sarılıklarla seyreden benign bir hastalıktır. Bu çalışmanın amacı, bilirubinin artmış seviyelerinin, kırmızı küre dağılım genişliği (RDW), ortalama trombosit hacmi (MPV), nötrofil/lenfosit oranı (NLR), platelet/lenfosit oranı (PLR) ve diğer hematolojik parametreler üzerindeki etkilerini araştırmaktır. Yöntem: İşe giriş muayeneleri için başvuran 20-28 yaş arası toplam 1190 genç erkek birey çalışmaya alındı. İşe giriş muayeneleri kapsamında ayrıntılı anamnez alımı, detaylı fizik muayene, hematolojik ve biyokimyasal parametreleri, tüm abdominal ultrasonografileri yapıldı. Kriterleri karşılayan 774 hasta arasından indirekt bilirubin yüksekliği dışında patolojik neticesi olmayan 63 hastaya Gilbert sendromu tanısı kondu. Kontrol grubu olarak 70 hasta rastgele olarak 711 hasta arasından seçildi. İstatistiksel olarak karşılaştırma ve korelasyon analizleri yapıldı. Bulgular: Gilbert sendromu grubunda RDW 12,0 ± 1,1; MPV 7,7 ± 0,7 fl; NLR 2,23±1,07; PLR 113,1±31,0 idi. Kontrol grubunun ise RDW değeri 11,8 ± 0,9 (p=0,153); MPV 8,2 ± 0,8 fl (pÖğe Is thyroid function associated with masked hypertension?(Turkish Society of Cardiology, 2016) Ateş, İhsan; Altay, Mustafa; Kaplan, Mustafa; Arıkan, Mehmet Fettah; Özkayar, Nihal; Alagüney, Mehmet Erdem; Dede, Fatih; Özkara, AdemMasked hypertension (MHT) was first defined by Pickering in 1992, and its importance is progressively increasing (1). MHT is a condition wherein blood pressure measured according to hypertension guidelines in office is normal, whereas the mean 24-h ambulatory blood pressure measurement or blood pressure measurement out of office is high (2). Studies relating to the etiology of MHT is limited, and possible etiological factors include work stress, smoking, alcohol use, male sex, and excessive physical activity (3, 4). The association between MHT and thyroid hormone, which has major effects on the cardiovascular system, is not known. This study aims to investigate the association between thyroid hormone and blood pressure in newly diagnosed MHT patientsÖğe Predictive factors of complications and 30-day mortality in patients undergoing percutaneous endoscopic gastrostomy: the utility of C-reactive protein to albumin ratio(Univ Catholique Louvain-Ucl, 2021) Düzenli, Tolga; Ketenci, Melis; Akyol, Tuğba; Köseoğlu, Hüseyin; Tanoğlu, Alpaslan; Kaplan, Mustafa; Yazgan, YusufBackground and study aims : Percutaneous endoscopic gastrost only (PEG) is a procedure that provides long term enteral nutrition. To investigate the predictors of PEG-related complications and 30-day mortality rates and evaluate the indicators for deciding whether to recommend elective PEG insertions, we sought to determine the complications and early mortality rates of patients who underwent PEG. Patients and methods : We performed a retrospective analysis of consecutive adult patients who had undergone PEG for the first time between October 2016 and January 2019. The predictors of complications and 30-day modality were analyzed with receiver operating characteristic (ROC) and logistic regression analysis. Results : This study included 309 patients. Patients were excluded from the study if they were < 18 years of age or there were missing data about them. Out of 253 patients, 33 (13%) had complications and 32 (12.6%) died within one month after PEG insertion. A higher C-reactive protein (CRP) to albumin ratio was the only independent factor predicting the complications (odds ratio (OR) : 3.17 ; 95% CI : 1.26-8.00 ; p = 0.014). The independent predictive factors for 30-day mortality after PEG placement included higher urea levels and higher CRP to albumin ratios (OR : 3.78 ; 95% CI : 1.41-10.17 ; p = 0.008) (OR : 6.67 ; 95% CI : 1.87-23.75 ; p = 0.003). The only predictor for both complications and 30-day mortality was the CRP to albumin ratio. Conclusions : When appropriate, the PEG procedure can provide a safe and effective method for enteral feeding. The CRP to albumin ratio can be used to predict complications and early mortality after PEG insertion. Because PEG is elective, higher CRP to albumin ratios can be helpful in deciding to select patients for the procedure.Öğe Presepsin:albumin ratio and C-reactive protein:albumin ratio as novel sepsis-based prognostic scores A retrospective study(Springer Wien, 2020) Kaplan, Mustafa; Düzenli, Tolga; Tanoğlu, Alpaslan; Çakır Güney, Başak; Önal Taştan, Yeşim; Biçer, Hatice SelcenObjective To investigate the prognostic value of the presepsin:albumin ratio and C-reactive protein:albumin ratio in patients with sepsis in the intensive care unit (ICU). Methods A total of 228 (129 males and 99 females) patients with newly diagnosed sepsis were included in the study. The relationship between the C-reactive protein:albumin ratio, presepsin:albumin ratio, clinicopathologic parameters, and overall survival were investigated. The associations between C-reactive protein:albumin ratio and presepsin:albumin ratio were evaluated alongside other inflammation-based prognostic scores such as quick Sepsis Related Organ Failure Assessment (qSOFA). Results The presepsin:albumin ratio was significantly higher in non-survivors (px202f;< 0.01). Patients with a high presepsin:albumin ratio had worse overall survival compared with patients with high C-reactive protein:albumin ratio levels (px202f;< 0.001). Conclusion Presepsin and presepsin:albumin ratio are markers of adverse prognosis in patients with sepsis and are superior to C-reactive protein and C-reactive protein:albumin ratio for this purpose. Presepsin:albumin ratio may be a novel marker of poor prognosis in patients with sepsis in intensive care units.Öğe Relationship between socioeconomic level, and the prevalence of masked hypertension and asymptomatic organ damage(International Scientific Information, Inc., 2015) Ateş, İhsan; Altay, Mustafa; Kaplan, Mustafa; Özkayar, Nihal; Toprak, Güvenç; Alagüney, M. Erdem; Özkara, AdemBackground: This study aimed to determine the prevalence of masked hypertension (MHT) and its association with asymptomatic organ damage (AOD) in a low socioeconomic district of Ankara, Turkey. Material/Methods: We retrospectively reviewed data obtained from the medical records of 712 patients with no known diagnosis of hypertension who presented to a polyclinic due to symptoms related to elevated blood pressure (BP) and were screened for MHT. Essential hypertension (EHT) existed in 86 patients screened for AOD. The presence of AOD in patients diagnosed with MHT and EHT was recorded. Results: Among the 712 patients, 206 were diagnosed with EHT. Among the remaining 506 patients, 73 were diagnosed with MHT. The patients with MHT had significantly higher left ventricular mass index, carotid intima-media thickness, and 24-h urinary microalbuminuria level (all indicators of AOD) than those with EHT. Conclusions: A significantly higher percentage of patients with MHT had AOD, as compared to those with EHT, in a low socioeconomic district of Ankara. Based on this finding, patients who present with hypertensive symptoms but have a normal BP should be advised to measure their BP at home. © Med Sci Monit, 2015.
