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    Case report of a rare cause of intestinal obstruction: Abdominal cocoon syndrome
    (Bayrakol Medical Publisher, 2020) Erkent, Murathan; Topcu, Ramazan; Yıldırım, Murat Baki; Ozkan, Murat Bulut; Şahin, Fatih; Keser Şahin, Havva Hande; Bostanoğlu, Settar
    Abdominal cocoon is a rare cause of ileus characterized by a pouch of a cocoon-like thick fibrous membrane partially or completely covering the small intestine and presents with acute and subacute intestinal obstruction findings. In this paper, we aimed to present a case operated for intestinal obstruction due to abdominal cocoon syndrome in light of the literature.
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    Clinical and pathological significance of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer
    (Elsevier Science Inc, 2021) Baş, Yılmaz; Koç, Nermin; Helvacı, Kaan; Koçak, Cem; Akdeniz, Raşit; Keser Şahin, Havva Hande
    We investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immunohistochemical analysis (CD3, CD4, CD8, PD-1 and PD-L1) was performed. Samples were analyzed for expression of immune proteins in the peritumoral stromal and intratumoral areas, scored, and expression was correlated with overall survival, stage, and age. PD-L1 staining ratio with a score greater than 0 was found to have lower survival. There were two positive staining patterns, patchy/diffuse and patchy/focal patterns, in 24 (25.5%) cases. Considering the threshold value >= 5%, we demonstrated that the PD-L1 positive cancer cell membrane immunoreactivity rate and patchy/diffuse PD-L1 expression were 9.6% (n = 9). There was statistically significant relationship between high PD-1 scores and PD-L1 cases of >= 5%. A statistically significant difference was found between PD-L1 staining and survival in patients with a threshold >= 5%. However an appropriate rate for treatment was determined in 9.6% cases. There was a statistically significant correlation between PD-1 positive TIL score and intratumoral CD3, peritumoral stromal CD3, intratumoral CD4 and intratumoral CD8 positive cells. Survival was lower in cases with higher PD-L1 positive stromal TIL score.
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    Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis
    (TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2022) Keskin, Emrah; Elmas, Özlem; Keser Şahin, Havva Hande; Güven, Berrak
    BACKGROUND: Annona muricata (AM) (graviola) is a plant that grows in tropical regions and is thought to be good for many diseases by local people. Unfortunately, there is no acceptable medical treatment for spinal cord injury (SCI) yet. In our study, we investigated the neuropeotective effects of AM leaf extract on SCI in an experimental rat model. METHODS: A total of 40 Wistar albino rats were randomly divided into five equal groups (n=8). Group 1 was the control group in which only laminectomy was performed. Trauma was induced in four groups after laminectomy. Group 2 (untreated trauma group) was given no medication. In Group 3, a single intraperitoneal dose of methylprednisolone (30 mg/kg) was administered after trauma. The rats in Groups 4 received a low dose (100 mg/kg) of AM leaf extracts by oral gavage one week before trauma while the rats in Group 5 received a high-dose (300 mg/kg) of these extracts by oral gavage one week before trauma. All rats, including the control group, were sacrificed 24 h after the trauma was created. RESULTS: Tissue samples taken to evaluate the neuroprotective effect were examined biochemically and histopathologically. Inflammatory findings in the trauma group were significantly better in both groups treated with AM. There was no difference between the groups in terms of clinical motor examination and inclined plane test results. CONCLUSION: Our histopathological and biochemical results showed that AM is an agent with neuroprotective effects in traumatic SCI.
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    Yassı hücreli karsinom ve keratoakantom ayırıcı tanısında GLUT-1, COX-2, MMP-19 ve p53’ün değeri
    (Türk Dermatoloji Derneği, 2019) Keser Şahin, Havva Hande; Baş, Yılmaz; Eğilmez, Hatice Reyhan
    Amaç: Bu çalışmada yassı hücreli karsinom (YHK) ve keratoakantom (KA) ayırıcı tanısında GLUT-1, COX-2, MMP-19, p53 ve Elastik-van Gieson (EVG) protein ekspresyonlarının anlamlı olup olmadığını araştırmak amaçlanmıştır. Yöntemler: Cumhuriyet Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı’nda 2001 ile 2011 tarihleri arasında tanı almış 105’i YHK, 51’i KA’dan oluşan toplam 156 olgu histokimyasal olarak EVG ve immünohistokimyasal olarak GLUT-1, COX-2, MMP-19 ve p53 çalışılarak incelendi. Bulgular: YHK ve KA ayırıcı tanısında GLUT-1, COX-2, MMP-19, p53 ve EVG ekspresyon değerleri istatistiksel olarak anlamlı bulundu (p<0,05). Tümör grupları arasında en fazla boyanma GLUT-1 (%54) ile, en az boyanma COX-2 (%9) ile görüldü. Çalışmadaki YHK ve KA olguları, GLUT-1 ile sırasıyla %60 ve %41 immünoreaktif; COX-2 ile sırasıyla %13 ve %2 immünoreaktif; MMP-19 ile sırasıyla %24 ve %0 immünoreaktif; p53 ile sırasıyla %31 ve %16 ile immünoreaktif ve EVG ile sırasıyla %20 ve %56,9 historeaktif bulundu. Sonuç: Çalışmamızda kullandığımız belirteçlerin YHK ve KA’nın ayırıcı tanısında yararlı olduğu görülmüştür. Ancak daha ileri moleküler ve genetik çalışmaların doğru tanıyı kolaylaştıracağını düşünüyoruz.