Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis

Yükleniyor...
Küçük Resim

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

TURKISH ASSOC TRAUMA EMERGENCY SURGERY

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

BACKGROUND: Annona muricata (AM) (graviola) is a plant that grows in tropical regions and is thought to be good for many diseases by local people. Unfortunately, there is no acceptable medical treatment for spinal cord injury (SCI) yet. In our study, we investigated the neuropeotective effects of AM leaf extract on SCI in an experimental rat model. METHODS: A total of 40 Wistar albino rats were randomly divided into five equal groups (n=8). Group 1 was the control group in which only laminectomy was performed. Trauma was induced in four groups after laminectomy. Group 2 (untreated trauma group) was given no medication. In Group 3, a single intraperitoneal dose of methylprednisolone (30 mg/kg) was administered after trauma. The rats in Groups 4 received a low dose (100 mg/kg) of AM leaf extracts by oral gavage one week before trauma while the rats in Group 5 received a high-dose (300 mg/kg) of these extracts by oral gavage one week before trauma. All rats, including the control group, were sacrificed 24 h after the trauma was created. RESULTS: Tissue samples taken to evaluate the neuroprotective effect were examined biochemically and histopathologically. Inflammatory findings in the trauma group were significantly better in both groups treated with AM. There was no difference between the groups in terms of clinical motor examination and inclined plane test results. CONCLUSION: Our histopathological and biochemical results showed that AM is an agent with neuroprotective effects in traumatic SCI.

Açıklama

Anahtar Kelimeler

Annona muricata, Methylprednisolone, Neuroprotection, Oxidative stress, Spinal cord injury

Kaynak

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

28

Sayı

3

Künye

Keskin, E., Elmas, Ö., Şahin, H. H. K., & Güven, B. (2022). Efficacy of Annona muricata (graviola) in experimental spinal cord injury: biochemical and histopathological analysis. Turkish Journal of Trauma and Emergency Surgery, 28(3), 233.