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Öğe Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin(Royal Society of Chemistry, 2020) Özkahraman, Bengi; Emeriewen, Krisztina; Saleh, George Michael; Thanh, Nguy?n Thi KimHerein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly(Nvinylcaprolactam-co-hyaluronic acid) (p(VCL-co-HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity.