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    An experimental study on the use of lycopene to prevent infertility due to acute oxidative ovarian damage caused byasingle high dose ofmethotrexate
    (Wroclaw University of Medicine, 2020) Türkler, Can; Onat, Taylan; Yıldırım, Engin; Kaplan, Selçuk; Yazıcı, Gülce Naz; Mammadov, Renad; Sunar, Mukadder
    Background. Methotrexate (MTX) is an antineoplastic agent, which increases the level of reactive oxygen species (ROS) and decreases the level of antioxidants. Lycopene, is a potent antioxidant, which is used because of its protective effect against tissue amage.Objectives. The aim of this study wasto determine the effect of lycopene on ovarian MTX-induced injury in rats.Material and methods. Rats (n = 36) were randomly divided into 3 equal groups: a group with MTX only (MG, n = 12), a group with lycopene and MTX (LMG, n = 12), and a healthy control group (HCG, n = 12). Then, malondialdehyde (MDA), myeloperoxidase (MPO) and total glutathione (tGSH) levels and histopathological findings were examined in the ovaries of rats. Apart from the histopathological and biochemical evaluation, the reproductive performance of the experimental groups was also examined.Results. Our study demonstrated that, in ovarian tissues of rats administered MTX, there was a decrease in the levels of tGSH, while MDA and MPO were increased, but it is observed that these ratios are reversed in the LMG (p < 0.05). It also has been proven that a single, high-dose use of MTX causes infertility in female rats, prolongs the gestation period and reduces the number of offspring.Conclusions. Lycopene pretreatment ameliorates the MTX induced ovarian injury and infertility in rats through its antioxidative activities
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    Global Research Trends On Vaginismus And Female Sexual Dysfunction In 1980-2019: A Scientometric Analysis
    (2020) Yıldırım, Engin; Derici, Mehmet Kürşat; Türkler, Can
    Objective: Physiological and psychological conditions can cause female sexual dysfunction (FSD). It is called vaginismus when sexual dysfunction occurs with vaginal cramps and spasms. The aim of our research is to present the research topics and trends about FSD and vaginismus to the reader in a global context Material and Methods: We used the terms ‘female sexual dysfunction’ and ‘vaginismus’ as keywords and we determined the articles indexed in the Web of Science database. We included all the articles in the database between 1980 and 2019. Documents of 2020 were excluded from this study. Gunnmap free open web-based application was used to visualize global research productivity. Vos-viewer 2019 program was used to determine the scientific relevance of the data. Results: We reached 2212 documents in total, 95.6 % of these articles were written in English, and 64.4% of the documents were original articles. Articles about vaginismus and FSD increased in the 1995s, the most productive year was 2019. The most productive country in genital cosmetics and aesthetics was the United States (USA), the most productive university was The University of British Columbia. The most productive writer was Goldstein I. Conclusion: Studies on vaginismus and FSD have increased over the past decade, and and non-invasive psychiatric interventions appear to be popular. Our analysis is an identity provider for articles covering vaginismus and FSD.
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    Umbilical arterial endocan levels can predict early neonatal pneumonia: A prospective case control study
    (Elsevier Ireland Ltd, 2020) Yıldırım, Engin; Türkler, Can; Demir, Emre; Tüten, Abdülhamit; Akcay, Ahmet
    One of the most important component soft heneonatal examination is thee valuation of the respiratory system. Respiratory system diseases of the newborn include a wide spectrum from transient tachypnea torespiratory distress syndrome