An experimental study on the use of lycopene to prevent infertility due to acute oxidative ovarian damage caused byasingle high dose ofmethotrexate
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wroclaw University of Medicine
Erişim Hakkı
Attribution 3.0 Unported (CC BY 3.0)
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Background. Methotrexate (MTX) is an antineoplastic agent, which increases the level of reactive oxygen species (ROS) and decreases the level of antioxidants. Lycopene, is a potent antioxidant, which is used because of its protective effect against tissue amage.Objectives. The aim of this study wasto determine the effect of lycopene on ovarian MTX-induced injury in rats.Material and methods. Rats (n = 36) were randomly divided into 3 equal groups: a group with MTX only (MG, n = 12), a group with lycopene and MTX (LMG, n = 12), and a healthy control group (HCG, n = 12). Then, malondialdehyde (MDA), myeloperoxidase (MPO) and total glutathione (tGSH) levels and histopathological findings were examined in the ovaries of rats. Apart from the histopathological and biochemical evaluation, the reproductive performance of the experimental groups was also examined.Results. Our study demonstrated that, in ovarian tissues of rats administered MTX, there was a decrease in the levels of tGSH, while MDA and MPO were increased, but it is observed that these ratios are reversed in the LMG (p < 0.05). It also has been proven that a single, high-dose use of MTX causes infertility in female rats, prolongs the gestation period and reduces the number of offspring.Conclusions. Lycopene pretreatment ameliorates the MTX induced ovarian injury and infertility in rats through its antioxidative activities
Açıklama
Anahtar Kelimeler
Methotrexate, Infertility, Oxidative Stress, Rat, Lycopene
Kaynak
Advances in Clinical and Experimental Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
29
Sayı
1
Künye
Turkler, C., Onat, T., Yildirim, E., Kaplan, S., Yazici, G. N., Mammadov, R., Sunar, M. (2020). An experimental study on the use of lycopene to prevent infertility due to acute oxidative ovarian damage caused by a single high dose of methotrexate. Advances in clinical and experimental medicine: official organ Wroclaw Medical University, 29(1), 5-11.
