An experimental study on the use of lycopene to prevent infertility due to acute oxidative ovarian damage caused byasingle high dose ofmethotrexate

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dc.authorid0000-0003-2716-0322
dc.authorid0000-0002-8920-1444
dc.authorid0000-0001-7937-4141
dc.authorid0000-0002-2887-6165
dc.authorid0000-0002-6989-997X
dc.authorid0000-0002-5785-1960
dc.authorid0000-0002-6744-3848
dc.contributor.authorTürkler, Can
dc.contributor.authorOnat, Taylan
dc.contributor.authorYıldırım, Engin
dc.contributor.authorKaplan, Selçuk
dc.contributor.authorYazıcı, Gülce Naz
dc.contributor.authorMammadov, Renad
dc.contributor.authorSunar, Mukadder
dc.date.accessioned2020-03-09T07:07:11Z
dc.date.available2020-03-09T07:07:11Z
dc.date.issued2020en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBackground. Methotrexate (MTX) is an antineoplastic agent, which increases the level of reactive oxygen species (ROS) and decreases the level of antioxidants. Lycopene, is a potent antioxidant, which is used because of its protective effect against tissue amage.Objectives. The aim of this study wasto determine the effect of lycopene on ovarian MTX-induced injury in rats.Material and methods. Rats (n = 36) were randomly divided into 3 equal groups: a group with MTX only (MG, n = 12), a group with lycopene and MTX (LMG, n = 12), and a healthy control group (HCG, n = 12). Then, malondialdehyde (MDA), myeloperoxidase (MPO) and total glutathione (tGSH) levels and histopathological findings were examined in the ovaries of rats. Apart from the histopathological and biochemical evaluation, the reproductive performance of the experimental groups was also examined.Results. Our study demonstrated that, in ovarian tissues of rats administered MTX, there was a decrease in the levels of tGSH, while MDA and MPO were increased, but it is observed that these ratios are reversed in the LMG (p < 0.05). It also has been proven that a single, high-dose use of MTX causes infertility in female rats, prolongs the gestation period and reduces the number of offspring.Conclusions. Lycopene pretreatment ameliorates the MTX induced ovarian injury and infertility in rats through its antioxidative activities
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dc.identifier.citationTurkler, C., Onat, T., Yildirim, E., Kaplan, S., Yazici, G. N., Mammadov, R., Sunar, M. (2020). An experimental study on the use of lycopene to prevent infertility due to acute oxidative ovarian damage caused by a single high dose of methotrexate. Advances in clinical and experimental medicine: official organ Wroclaw Medical University, 29(1), 5-11.
dc.identifier.doi10.17219/acem/111809
dc.identifier.endpage11en_US
dc.identifier.issn1899–5276
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage5en_US
dc.identifier.urihttps://hdl.handle.net/11491/5774
dc.identifier.volume29en_US
dc.identifier.wosWOS:000512951500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWroclaw University of Medicine
dc.relation.ispartofAdvances in Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 3.0 Unported (CC BY 3.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subjectMethotrexateen_US
dc.subjectInfertilityen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.subjectLycopeneen_US
dc.titleAn experimental study on the use of lycopene to prevent infertility due to acute oxidative ovarian damage caused byasingle high dose ofmethotrexate
dc.typeArticle

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