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    Öğe
    Analysis of Interleukin-1 Receptor Antagonist Variable Number Tandem Repeat Variant in Recurrent Aphthous Stomatitis
    (Bentham Science Publ Ltd, 2021) Tekcan, Akin; Yigit, Serbulent; Nursal, Ayse F.; Tumer, Mehmet K.; Yerliyurt, Kaan; Kuruca, Nilufer
    Background/Aims: Recurrent aphthous stomatitis (RAS) is one of the common oral inflammatory diseases. As immunological and genetic factors have been held responsible for the pathogenesis of RAS, the objective of this study was to determine whether the interleukin-1 receptor antagonist (IL-1Ra) gene variable number tandem repeat (VNTR) variant is a risk factor for the development of RAS in Turkish patients and to define its contribution to the increased risk. Methods: The IL-1Ra VNTR variant was evaluated in 169 RAS patients and 171 healthy controls by the polymerase chain reaction (PCR) method. Results: No statistically significant difference was found in the genotype distributions and allele frequencies of IL-1Ra VNTR variant between RAS patients and healthy controls. Conclusion: Lack of association between IL-1Ra VNTR variant and RAS could indicate that IL-1Ra has no significant role in the pathophysiology of RAS. However, it still appears to be very worthwhile to continue to search for cytokine gene variants in order to predict the development of such disease.
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    Öğe
    Importance of NPC1 Gene 644 A -> G Mutation in Coronary Artery Disease
    (Kamla-Raj Enterprises, 2017) Ozturk, Sibel Demir; Celik, Atac; Nursal, Ayse Feyda; Tekcan, Akin; Rustemoglu, Aydin; Karakus, Nevin; Yigit, Serbulent
    Coronary artery disease (CAD) is the most prominent cause of mortality worldwide. The basis of CAD pathogenesis is the occlusion of coroner vessels progressively due to atherosclerotic plaques. NPCI gene plays a critical role in the atherosclerosis progression. This study aimed to examine whether 644 A -> G polymorphism of NPCI is associated with the risk of coronary artery disease in Turkish patients. In this case-control study, 200 persons were studied (100 patients and 100 controls). The 644 AEG polymorphism of NPCI gene is analyzed using polymerase chain reaction and restriction fragment length polymorphism methods. There was a significant relationship between the distribution of coronary artery disease and control group in terms of allele and genotype frequency (p= 0.0002) (p=0.003), respectively. According to the researchers' results, 644 A -> G polymorphism in NPCI gene can be one of the predisposition factor to coronary artery disease in Turkish population.