Importance of NPC1 Gene 644 A -> G Mutation in Coronary Artery Disease
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Kamla-Raj Enterprises
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Coronary artery disease (CAD) is the most prominent cause of mortality worldwide. The basis of CAD pathogenesis is the occlusion of coroner vessels progressively due to atherosclerotic plaques. NPCI gene plays a critical role in the atherosclerosis progression. This study aimed to examine whether 644 A -> G polymorphism of NPCI is associated with the risk of coronary artery disease in Turkish patients. In this case-control study, 200 persons were studied (100 patients and 100 controls). The 644 AEG polymorphism of NPCI gene is analyzed using polymerase chain reaction and restriction fragment length polymorphism methods. There was a significant relationship between the distribution of coronary artery disease and control group in terms of allele and genotype frequency (p= 0.0002) (p=0.003), respectively. According to the researchers' results, 644 A -> G polymorphism in NPCI gene can be one of the predisposition factor to coronary artery disease in Turkish population.
Açıklama
Anahtar Kelimeler
CAD, Niemann-pick Type C1 Gene, Polymorphism, Predisposition, RFLP
Kaynak
International Journal Of Human Genetics
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
17
Sayı
2
