Importance of NPC1 Gene 644 A -> G Mutation in Coronary Artery Disease

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dc.authoridRustemoglu, Aydin / 0000-0002-1354-4598
dc.authoridYigit, Serbulent / 0000-0002-1019-3964
dc.authorwosidTEKCAN, AKIN / AAB-9277-2020
dc.authorwosidRustemoglu, Aydin / S-2004-2016
dc.authorwosidYigit, Serbulent / ABB-9572-2020
dc.contributor.authorOzturk, Sibel Demir
dc.contributor.authorCelik, Atac
dc.contributor.authorNursal, Ayse Feyda
dc.contributor.authorTekcan, Akin
dc.contributor.authorRustemoglu, Aydin
dc.contributor.authorKarakus, Nevin
dc.contributor.authorYigit, Serbulent
dc.date.accessioned2021-11-01T15:01:46Z
dc.date.available2021-11-01T15:01:46Z
dc.date.issued2017
dc.department[Belirlenecek]
dc.description.abstractCoronary artery disease (CAD) is the most prominent cause of mortality worldwide. The basis of CAD pathogenesis is the occlusion of coroner vessels progressively due to atherosclerotic plaques. NPCI gene plays a critical role in the atherosclerosis progression. This study aimed to examine whether 644 A -> G polymorphism of NPCI is associated with the risk of coronary artery disease in Turkish patients. In this case-control study, 200 persons were studied (100 patients and 100 controls). The 644 AEG polymorphism of NPCI gene is analyzed using polymerase chain reaction and restriction fragment length polymorphism methods. There was a significant relationship between the distribution of coronary artery disease and control group in terms of allele and genotype frequency (p= 0.0002) (p=0.003), respectively. According to the researchers' results, 644 A -> G polymorphism in NPCI gene can be one of the predisposition factor to coronary artery disease in Turkish population.
dc.identifier.doi10.1080/09723757.2017.1335486
dc.identifier.endpage55en_US
dc.identifier.issn0972-3757
dc.identifier.issue2en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://doi.org/10.1080/09723757.2017.1335486
dc.identifier.urihttps://hdl.handle.net/11491/6649
dc.identifier.volume17en_US
dc.identifier.wosWOS:000411299900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherKamla-Raj Enterprises
dc.relation.ispartofInternational Journal Of Human Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCADen_US
dc.subjectNiemann-pick Type C1 Geneen_US
dc.subjectPolymorphismen_US
dc.subjectPredispositionen_US
dc.subjectRFLPen_US
dc.titleImportance of NPC1 Gene 644 A -> G Mutation in Coronary Artery Disease
dc.typeArticle

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