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Investigation of the relationship between ACAN geneVNTR polymorphism and Alzheimer’s disease inTurkish population
(TAYLOR & FRANCIS INC, 2024) Keskin, Tuğba; Avşar, Orçun; Eliaçık, Sinan; Uysal Tan, Funda
Alzheimer’s disease is one of the most common causes of dementia and is a neurodegenerative disease that occurs with memory loss, loss of language, thinking and problem-solving skills. In this study, it was aimed to reveal the relationship between Alzheimer’s disease and the variable number tandem repeat (VNTR) polymorphism in the aggrecan (ACAN) gene. Thus, it is thought that it will contribute to enlightenment about disease by contributing to the pathophysiology of Alzheimer’s disease. A total of 203 people, including 102 patients diagnosed with Alzheimer’s and 101 healthy individuals, were included in the study. Deoxyribonucleic acid (DNA) extraction was performed from the blood samples taken. The variable number tandem repeat (VNTR) polymorphism of the ACAN gene was determined using the Polymerase Chain Reaction (PCR) method. In our study, the 30?R, 31?R and 33?R alleles were the most repetitive alleles in patients and controls. 30?R, 31?R and shorter alleles were more common in patients than in the control group and were found to be statistically significant (p?=?0.042). According to our results, 30?R and 31?R alleles of the VNTR polymorphism in the ACAN gene may be associated with Alzheimer’s disease. In addition, having less than 30 repeat alleles increases the risk of the disease by 2,202 times. Our study is the first to investigate the relationship between ACAN gene VNTR polymorphism and Alzheimer’s disease. Further studies are needed to definitively relate it.
The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats
(UNIV SAO PAULO, 2023) Danış, Seren; Can, Senanur; Yıldız, Fatma; Tan Yılmaz, Işıl; Canbek, Mediha; Özmen Yaylacı, Ayşe
Ischemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol.
Association of Serum Hepatocyte Growth Factor Level with Systemic Inflammatory Biomarkers in Patients with Pancreatobiliary Cancer
(Turkish Society of Gastroenterology, 2023) Ünek, İlkay Tuğba; Öztop, İlhan; Başpınar, Yasemin; Ünek, Tarkan; Leblebici, Asım; Çakıroğlu, Ece; Akagündüz, Baran; Ellidokuz, Hülya; Astarcıoğlu, İbrahim; Uysal Kılıç, Tuğba
Background: Hepatocyte growth factor is a cytokine secreted by the stromal cells in the tumor microenvironment. There is little information about the clinical significance of serum hepatocyte growth factor level in patients diagnosed with pancreatobiliary cancer. The objective of the current study was to investigate the relationship between serum hepatocyte growth factor level with inflammation markers and the clinical features of patients with pancreatobiliary cancer. Methods: A total of 62 patients with pancreatobiliary cancer were included in this study. Serum hepatocyte growth factor concentrations were evaluated utilizing the enzyme-linked immunosorbent assay method. Results: The median serum hepatocyte growth factor level was 329.1 ng/mL (1.4-1051.1). The patients were categorized into 2 groups as those below the median hepatocyte growth factor level (low hepatocyte growth factor) and those above the median hepatocyte growth factor level (high hepatocyte growth factor). While 40.9% of the patients without metastasis were observed to be in the high hepatocyte growth factor group, 72.2% of the metastatic patients were observed to be in the high hepatocyte growth factor group (P = .025). The median levels of monocyte, monocyte-to-lymphocyte ratio, C-reactive protein, and C-reactive protein-to-albumin ratio were found to be significantly higher in the high hepatocyte growth factor group as compared to the low hepatocyte growth factor group (P < .050). Conclusion: The significant relationship between serum hepatocyte growth factor level and systemic inflammation markers in patients with pancreatobiliary cancer is shown for the first time in our study. This study, which showed a significant relationship between the presence of metastasis and serum hepatocyte growth factor level, suggests that serum hepatocyte growth factor level may be a prognostic biomarker in patients who are diagnosed with pancreatobiliary cancer
Increased oxidative stress in adult women with iron deficiency anemia
(TRISAKTI UNIV, FAC MEDICINE, 2022) Karabulut, Alpaslan; Alp Avcı, Gülçin; Avcı, Emre
BACKGROUND Iron deficiency anemia (IDA), a type of anemia with an increasing global frequency, is more common in women than men in the population. In IDA, the sensitivity of erythrocytes to oxidants is increased and their lifespan is shortened. Oxidative stress is an imbalance between free radicals and antioxidant molecules which is one of the potential biochemical mechanisms involved in the pathogenesis of IDA. In our study, we aimed to determine the levels of oxidant and antioxidant markers by assessing the levels of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 (PON-1), and myeloperoxidase (MPO) in women with IDA. METHODS This was a cross-sectional study involving 47 women with IDA aged ?40 years and 47 women volunteers. The levels of TAS, TOS, OSI, PON-1, and MPO were determined spectrophotometrically using appropriate kits. Nonparametric Mann Whitney-U tests were used to analyze the data. RESULTS The levels of antioxidants TAS (1.42 mmol Trolox equiv./L) and MPO (54.00 U/L) in the IDA group were significantly lower than in the control group [TAS (1.67 mmol Trolox equiv./L) and MPO (89.00 U/L)] (p=0.000 and p= 0.019, respectively). However, TOS (6.25 ?mol H2O2 equiv./L) level in the IDA group was significantly higher than in the control group (4.13 ?mol H2O2 equiv./L) (p=0.000), but PON-1 was not significantly different between the two groups (p=0.375). CONCLUSION In women with IDA, the oxidant-antioxidant balance is impaired, resulting in oxidative stress. Therefore, IDA in adult women must receive adequate attention in clinical practice.
Analysis of missense SNPs in the SLC47A1 and SLC47A2 genes affecting the pharmacokinetics of metformin: Computational approach
(SPRINGERNATURE, 2022) Avşar, Orçun
Background: Metformin as an anti-hyperglycaemic drug is commonly used for the treatment of type 2 diabetes mellitus (T2DM). The metformin response is variable due to the interindividual variation of pharmacokinetics which is based on strong genetic background. MATE1 and MATE2 proteins are signifcantly implicated in the pharmacokinetics of metformin. Missense SNPs with high risk of pathogenicity are expected to afect response to metformin via pharmacokinetics. Therefore, the aim of the current study is to determine the efects of missense SNPs in the SLC47A1 and SLC47A2 genes. The structural and functional consequences of all known SLC47A1 and SLC47A2 missense SNPs of the human MATE1 and MATE2 proteins were identifed by various bioinformatics methods (SIFT, PhD-SNP, PolyPhen-2, PROVEAN, PMut, MUpro, I-Mutant 3.0, COACH, RaptorX Binding, ConSurf, STRING). Results: The SLC47A1 variants P186T, L116P and the SLC47A2 variants I158N, L112P, V118G exhibited ??G values less than ?1 kcal/mol, and these variants are considered to disrupt the structure and function of MATE1 and MATE2 proteins. SLC47A1 R118Q and SLC47A2 Y273C, V118G may signifcantly disturb protein function and transporting activities according to the analysis of ligand-binding regions. Conclusion: It is suggested that high-risk deleterious missense SNPs may mediate the pharmacokinetics of metformin and may be associated with altered tissue distribution, renal clearance and metformin toxicity. We suppose that our results might serve as potential targets for the studies composed of the development of potential diagnostic and therapeutic strategies based on the relationship between mutations and metformin response.
Terrestrial Vertebrate Fauna of Beytepe Campus, Hacettepe University
(2021) Şahin, Mehmet Kürşat; Akbaba, Burak; Bulut, Şafak; Ayaş, Zafer
Beytepe Campus (Hacettepe University) is one of the few isolated areas with large scale for wildlife within Ankara metropolis (Turkey). However, there is no checklist regarding to the terrestrial vertebrate (amphibian, reptile, avian and mammalian) fauna of this campus has ever been published so far. Therefore, field studies and literature surveys were conducted towards Beytepe Campus from 2005 to 2019. According to the results, a total of 3 amphibians, 11 reptilians, 93 avian and 14 mammalian species were identified in the study area. Due to increasing urbanization trends in this metropolitan city, this study will provide us a useful guide for further surveys and conservation activities in similar areas.
In Silico Analysis of miRNA-mediated ceRNAs as Potential Molecular Biomarkers in Glioblastoma
(2021) Avşar, Orçun
Objectives: Glioblastoma multiforme (GBM) is defined as the most frequent and lethal form of the primary brain tumors in the central nervous system (CNS) in adults. Recent studies have focused on the identification of the new targets for the diagnosis and treatment of GBM and resulted in great interest for miRNAs due to their regulatory effects in cancer pathogenesis. Thus, we aimed to characterize novel molecular biomarkers for GBM by computational analysis. Methods: 118 miRNAs that are clinically related with glioblastoma and proven by experimentally were exported through miRTarBase database. 1016 genes projected by these 118 miRNAs were determined via ComiR database. Subsequently, the genes with transcribed ultraconserved regions (T-UCRs) in their exonic regions were designated and the genes which have potential competing endogenous RNA (ceRNA) activities were extracted. Genes with remarkable expression profile differences between glioblastoma and normal brain tissues among ceRNAs that are associated with glioblastoma involving T-UCR were identified. Results: The statistical analysis of the correlation between PBX3 and NRXN3 genes and glioblastoma was carried out by Spearman correlation test. PBX3 and NRXN3 expression was significantly higher and lower in glioblastoma than in normal brain tissues, respectively. On the other hand, the other genes did not have any remarkable differential expression pattern. Conclusion: Based on the findings of the current study, it is determined that NRXN3 acts as a tumor suppressor gene and NRXN3 gene is downregulated in GBM. PBX3 gene functions as an oncogene and is upregulated in GBM.
Tümör Gelişiminde ve Tedavisinde Dopamin ve Dopamin Reseptörlerinin Rolü
(2020) Avşar, Orçun
Önemli bir katekolamin nörotransmitter olan dopamin, santral sinir sisteminde ve sindirim sistemi, dalak ve pankreas gibi periferik dokularda sentez edilmektedir. Hem santral sinir sisteminde hem de pe-riferal sistemde dopamin, çeşitli biyolojik fonksiyonları dopamin re-septörleri aracılığıyla düzenlemektedir. Santral sinir sistemindeki dopamin reseptörleri, D1-benzeri ve D2-benzeri olmak üzere 2 alt gruba ayrılmaktadır. Diğer taraftan, periferdeki dopamin reseptörleri ise DA1 ve DA2 olmak üzere 2 alt gruba ayrılmaktadır. Dopamin re-septörlerinin ekpresyon düzeyleri, farklı tümör tiplerinde ve tümör ge-lişiminin farklı aşamalarında farklılık göstermektedir. Nöron kültürü çalışmalarında dopamin tarafından hücre siklusunun durmasının, DNA fragmentasyonunun ve apoptozun indüklendiği gösterilmiştir. Birçok çalışmada dopaminin anjiyogenezi baskılayarak, tümör büyümesini in-hibe ettiği ve bu süreci yöneten en önemli bileşenin ise DRD2 olduğu belirlenmiştir. Matriks metalloproteinazlar (MMPs), tümör invazyonu ve metastazında önemli rol oynamaktadır. Dopamin, DRD2 aracılığıyla MMP-13 ekspresyon seviyelerinin düşmesine neden olmaktadır. Do-pamin ve reseptörleri birçok immün sistem hücresinde sentez edilmek-tedir. Dopamin, nöral sistem ile immün sistem arasındaki iletişimi sağlayan en önemli bileşenlerdendir. Ek olarak dopamin, yardımcı T hücrelerinin farklılaşmasını, polarizasyonunu, sitokin sekresyonunu ve efektör fonksiyonunu etkilemektedir. Dopamin reseptörlerinin bloke edilerek ya da aktive edilerek hedeflenmesi, kanser tedavisinde temel bir stratejidir. Dopamin reseptörlerinin ekspresyon özelliklerinin, de-ğişen kanserli durumlarda detaylı olarak bilinmesi kanser tedavisi açı-sından oldukça önemlidir. Benzer şekilde, dopamin ve immün sistem arasındaki etkileşimlerin daha iyi anlaşılması, kanser tedavisi için önem arz etmektedir. Bu derlemede, dopamin ve dopamin reseptörlerinin kan-ser hücre ölümü, anjiyogenez, invazyon ve metastaz ile ilişkisi açık-lanmaya çalışılmıştır. Ek olarak, dopamin ve dopamin reseptörleri ile immün sistem arasındaki ilişki açıklanmıştır.
Inventory of Large Mammal Species in the Ilgaz Mountains (Cankiri): A Major Ecological Corridor in Anatolia
(2020) Akbaba, Burak; Bulut, Şafak
In order to understand the processes engendered by different faunal elements in natural systems, and to plan how such systems should be managed and conserved, it is essential to start by determining the presence of those faunal elements, even large mammals. The entire range of North Anatolian Mountains provides suitable sheltering and feeding habitats for large mammals. The region stretching between Köroğlu Mountains (west) and Ilgaz Mountains (east) is one of the most important Anatolia’s wildlife corridors. We located and identified the species of large mammals in the Ilgaz Mountains, as well as specific habitats used by them. Field studies carried out in this region during April-August 2017 resulted in 180 records of nine different species of large mammals: Lepus europaeus, Ursus arctos, Canis lupus, Vulpes vulpes, Lynx lynx, Meles meles, Sus scrofa, Cervus elaphus and Capreolus capreolus. To obtain those records took 621 days of studying with camera traps. Among those species, European hare was the most frequently recorded herbivore (101), and brown bear was the most frequently recorded carnivore (19). Both hare and roe deer displayed clustered distribution patterns in the region. The analysis of our records showed that lynx, boar, and fox were strictly nocturnal; whereas hare and wolf were predominantly nocturnal. We also obtained records of the cubs of many large mammal species (bear, lynx, boar, red deer, roe deer) although we did not encounter any large mammal nests during the study.
Habitat Selection Of Small Mammals in A Mixed Forest in Turkey
(Corvinus Univ Budapest, 2021) Bulut, Şafak; Karataş, Ahmet; Ayas, Zafer
Small mammals is a non-taxonomic subgroup named on the basis of body size of individuals. This study was created from data obtained through the mark-recapture method of small terrestrial mammals in Populus tremula, thermophilic deciduous, steppes, conifer plantations and Abies sp. forest habitats in Turkey. Field studies were performed for a total of 14 months in 2014 and 2015. 758 individuals from seven species were captured in a total of 5250 days in trapping grid studies conducted in a total of 5 different types of habitat by a grid of 5 ? 5 traps system. The average capture success in all was calculated as 14.44%. The species affected by temperature data were M. glareolus and D. nitedula. It was found that M. subterraneus showing increasing populations was negatively correlated with temperature. When considering the sex ratios, M. glareolus was under intense male pressure in steppe habitat. Indicator species were determined numerically and M. glareolus, M. subterraneus and D. nitedula were found to be decisive species for different habitats. The habitats showing most similarity to each other in terms of habitat preferences of small mammals the pine plantation and Abies forest, the most different habitat was steppe.
Camera trap records confirm the survival of the Leopard (Panthera pardus L., 1758) in eastern Turkey (Mammalia: Felidae)
(Taylor & Francis Ltd, 2021) Karataş, Ahmet; Bulut, Şafak; Akbaba, Burak
The Leopard, Panthera pardus, was thought to be extinct or on the verge of extinction in Turkey towards the end of the 20(th) century. However, as leopards killed by local people were reported from the Turkish-Iraqi border area in the last two decades, we carried out field surveys in these regions in order to find out whether the species has survived. We set camera traps at more than 150 locations in Mardin, Siirt and Sirnak provinces in south-eastern Turkey in 2018 and 2019 and succeeded in obtaining altogether three pictures of leopards, probably of the same individual. The photographs, taken in July and December 2018, and in November 2019, are from two different sites on the northern slopes of Mount Cudi. Together with previous records, these observations indicate that a small population of the leopard has survived in the Turkish-Iraqi border area. Cudi Mountain may serve as a corridor for leopards moving between Turkey, Iraq and Iran. Our records comprise the first photographic evidence of living leopards in Turkey in the wild.
Cytogenetics Analyses of The Genus Spermophilus Cuvier 1825 (Mammalia Rodentia) Distributed in Turkey
(Parlar Scientific Publications (P S P), 2021) Bulut, Şafak; Arslan, Cemil
Cytogenetic analysis were studied on three species of the genus Spermophilus distributed in Turkey (S. citellus, S. xanthoprymnus and S. taurensis). Different chromosomal features occurring in different subpopulations of S. xanthoprymnus, which has a wide distribution area in Anatolia and the lack of Turkey's population of banded chromosome studies in S. citellus and the fact that different chromosome morphologies are still encountered in the S. taurensis population led us to carry out this study. In this study, G, C and Ag-NORs banding of S. xanthoprymnus, sampled from Bolkar Mountains, and S. citellus from Turkish Thrace were performed. The C-banding patterns and Ag-NORs chromosome features was given for the first time from the samples of S. citellus from Turkey. In addition, new chromosomal features of S. taurensis, an endemic species, were also presented. In this study, diploid chromosome number of S. xanthoprymnus was 2n=42, fundamental chromosome number (NF) was 82, autosomal chromosome number (NFa) was 78, while C banding revealed a heterochromatin region in one chromosome. Because of Ag-NOR staining of S. xanthoprymnus, eight NOR stains were determined in the male sample, and we detected six NOR stains in the female sample. The diploid chromosome number of S. citellus species was determined as 2n= 40, NF=77, NFa=74, while C banding revealed a heterochromatin area in two chromosomes. As a result of Ag-NOR staining of S. citellus species, seven NOR staining were detected. S. taurensis species, diploid chromosome number was determined as 2n=40, NF=80 and NFa=76. The G, C banding patterns and Ag-NORs chromosome features was given for the first time from the samples of S. citellus obtained from Turkish Thrace. In addition, new chromosomal features of S. taurensis, an endemic species, were also presented.
Probable Novel Probiotics: Eps Production, Cholesterol Removal and Glycocholate Deconjugation of Lactobacillus Plantarum Ga06 and Ga11 Isolated from Local Handmade- Cheese
(Slovak Univ Agriculture Nitra, 2020) Alp Avcı, Gülçin; Çağatay, Gamze; Özlük Çilak, Gizem; Avcı, Emre; Alp Avcı, Gülçin
In this study, it was aimed to investigate the effect of exopolysaccharide produced by 2 novel probiotic strains (Lactobacillus plantarum GA06 and GA11), isolated from local handmade cheese, on cholesterol mechanism and bile deconjugation. These two strains were thought to play an important role in cholesterol removal and may contribute to intestinal microbiota positively. The bacterial 16S rRNA gene sequencing analysis was used for molecular identification of the strains. Exopolysaccharide production of the strains was identified by the phenol-sulphuric acid method whereas cholesterol removal and glycocholate deconjugation activity were evaluated via spectrophotometric methods. The exopolysaccharide production of L. plantarum GA11 and GA06 was determined as 96.5 and 32.5 mg/L, and the cholesterol removal amounts were found as 36.7% and 28.6% respectively. Glycocholate deconjugation activity of GA11 was detected higher than of GA06. A statistically significant difference was observed between the EPS production capacity of the strains and the removal of cholesterol (p<0.05). And also, a statistically significant correlation was found both between the EPS production capacity- cholesterol removal and between EPS production capacity-glycocholate deconjugation. According to the results of our study, L. plantarum GA11 strain appears to be a good and novel probiotic strain that has high probiotic potential. Further studies can be confirmed to determine specific more crucial health benefits.
The Effect of Exercise on Serum Homocysteine, Adma, Neopterin and Oxidative Stress Levels in Young Male Athletes
(Int Journal Applied Exercise Physiology, 2018) Can, Sema; Demirkan, Erkan; Avcı, Emre
Elevated homocysteine (HCY), asymmetric dimethylarginine (ADMA), Neopterin (NP) and oxidative stress have been established as risk factors for vascular disease and coronary artery disease. The purpose of the study was (a) to assess the HCY, ADMA, NP, malondialdehyde (MDA) and glutathione (GSH) levels and (b) to determine the relationship between these parameters in wrestlers, track and field athletes, and non-athletes. 35 subjects in total, comprising of 15 wrestlers ((x) over bar = 17.6 +/- 2.3 years), 10 track and field athletes ((x) over bar = 16.6 +/- 2.2 years) and 10 non-athletes((x) over bar = 17.2 +/- 0.8 years) voluntarily participated in the study. The HCY, ADMA, NP, MDA, GSH levels as in subjects' blood was performed through the antecubital vein in the morning while in the pre-prandial state. There was a significant difference in ADMA, MDA, GSH concentrations between in track and field athletes and wrestlers. There was a significant difference in HCY, NP concentrations between wrestlers and non-athletes. There was a significant difference in HCY, MDA concentrations between track and field athletes and non-athletes (p< 0.05). The HCY and NP showed high level correlation in all groups (track and field athletes; r = .952; wrestlers; r = .886; non-athletes; r = .900; p< 0.01). The GSH and NP showed high level negative correlation in non-athletes (r = - .900; p< 0.01). According to the results of HCY, ADMA, NP, MDA, the lowest level was found in athletes and the highest appeared in the non-athletes. In conclusion, we think that regular training may have positive effects on cardiovascular and anti antioxidant level.
Do acute weight loss and gain affect hydration status in adolescent wrestlers?
(Archives Budo Science Martial Arts & Extreme Sports, 2017) Demirkan, Erkan; Avcı, Emre; Gargi, Ramazan
Background & Study Aim: The rapid weight loss and gain is a common practice in wrestlers within a week before the competition. The aim of this study was the effects of rapid weight loss and gain before official weigh-in, along with during the competition in adolescent wrestlers. Material & Methods: Twenty-four collegiate wrestlers (twelve of them as the competitors, other as non-competitor wrestlers) volunteered as subjects in the present study. Body composition was assessed by using a bioelectrical impedance device (bioelectrical impedance analysis; abbreviation BIA). Hydration status was determined via to urine specific gravity (USGV) that taken urine samples. The body mass and hydration status were evaluated: seven days before official weigh in (a); three days before the official weigh-in (b); morning of the official weigh-in (c); the official weigh-in time (d); before the beginning of the first bout (e); the following day morning (f). Results: There was a significant difference in body weight changes between the first weight assessment (a) and weigh in competition (d) in competitor wrestlers (p<0.05). In hydration status, there was a significant difference between the first USGV analysis (a) and other assessments (b, c, d, e, f) (p<0.05). However, there was no significant difference in hydration status between the weigh-in competition USGV (d) and others (e, f) (p>0.05). Conclusion: The duration of the official weigh-in and the competition is not enough for wrestlers to rehydrate. The process of weight loss and hydration status should be monitored by coaches, not before a week but in a long time. Individual fluid intake strategies should be developed for athletes to be minimising dehydration risk before and during the competition.
New distribution records of Bohemian Waxwing Bombycilla garrulus (Linnaeus, 1758) from Turkey
(Universitatea din Oradea, 2019) Karataş, Ahmet; Bulut, Şafak; Karataş, Ayşegül
The Bohemian Waxwing (Bombycilla garrulus Linnaeus, 1758) is a rare and high irregular migrant in Turkey. Most of records from the country have been taken in winter season. In this study, four winter and one spring observations were reported from five new localities. In additionally, some information on its ecology, behaviour and subspecific status were given. ©Biharean Biologist, Oradea, Romania, 2019
Taxonomic status of Dahl’s Jird, Meriones dahli, as inferred from cytochrome b and IRBP gene sequences (Mammalia: Rodentia)
(Taylor and Francis Ltd., 2021) Bulut, Şafak; Olgun Karacan, Gül
Dahl’s Jird, Meriones dahli, is distributed in Armenia and eastern Turkey and was previously considered as a subspecies of M. meridianus based on morphological characters. We examined the taxonomic status of Dahl’s Jird using two gene regions, the mitochondrial cytochrome b (Cytb) gene and the Inter Retinoid Binding Protein (IRBP), a nuclear gene. Phylogenetic trees and median-joining networks confirmed the close relationship between M. dahli and M. meridianus. The evolutionary divergence time between these populations was estimated 750 Kya, indicating that these populations diverged in the Middle Pleistocene. The genetic distance between M. dahli and M. meridianus was 4% for Cytb and 0.6% for IRBP. In conclusion, we characterized the genetic distance using molecular methods. We propose the relegation of M. dahli back to subspecies status as M. m. dahli. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
The present status, distribution, demography, and diet of the Dahl’s Jird
(Instituto Internacional de Ecologia, 2022) Bulut, Şafak
Meriones dahli (Shidlovsky, 1962) was previously accepted to be a subspecies of M. meridianus (Pallas, 1773). However, it was later suggested that they are geographically isolated from each other. Although hybridological studies and differences in certain external characteristics support the idea that M. dahli is a separate species, there are still doubts on its species status, and the exact range of its distribution is not known. In this paper, we provide some taxonomic information about the species, and compare these with the information given in previous studies. We argue that some differences exist among Armenian population regarding external measurements. Recent studies indicate that M. dahli is currently only distributed in Turkey, as an endemic mammal species. We provide predictions about the distribution of M. dahli, and report the estimated population size to its maximum value. Food preference studies for this species, conducted under laboratory conditions, are also introduced for the first time. We discuss the ecological data obtained from field studies, and emphasize that the habitat of M. dahli is about to disappear. Consequently, the protection status of this species should urgently be changed to the CR category and conservation studies must be carried out immediately. © 2022, Instituto Internacional de Ecologia. All rights reserved.
Novel coordination compounds: Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) cations with acesulfame/N,N-diethylnicotinamide ligands
(Taylor and Francis Ltd., 2020) Yıldırım, Tuğrul; Köse, Dursun Ali; Alp Avcı, Gülçin; Şahin, Onur; Akkurt, Fatih
Five coordination complexes with Mn2? (1), Co2? (2), Ni2? (3), Cu2? (4), and Zn2? (5) containing acesulfame (ace) and N,N-diethylnicotinamide (dena) ligands were synthesized and structural binding properties investigated. Four compounds (1, 2, 4, and 5) were examined with single crystal X-ray diffraction methods. The structures containing Mn(II), Co(II), and Zn(II) were iso-structural. Six-coordination of metal cations were completed with two moles dena and four aqua ligands. The dena ligands were coordinated via pyridine nitrogen as neutral-monodentate. Charge stabilities of the complexes are complemented by two moles monoanionic ace ligands, located outside of the coordination unit. In the Cu(II) complex, the coordination is completed by acidic nitrogen and carbonyl oxygen atoms of two ace ligands and pyridine nitrogen of two moles dena ligands. The coordination to Cu(II) for ace ligands was monoanionic-bidentate. All metal cations in the structure are distorted octahedral. Thermal decomposition of complexes begins with removal of the aqua molecules from the structures and is completed by combustion of organic ligands. The final decomposition products of all structures have been identified as corresponding metal oxides. Some biological applications (anti-fungal/anti-bacterial) were studied using 1–5.
Two novel mixed-ligand zinc-acesulfame compounds: Synthesis, spectroscopic and thermal characterization and biological applications
(Elsevier B.V., 2020) Yurdakul, Ömer; Köse, Dursun Ali; Şahin, Onur; Alp Avcı, Gülçin
Two new tetrahedral acesulfame complexes, acesulfamato(N)acesulfamato(O)bis(3-aminopyridine) zinc(II) (C18H20N6O8S2Zn, Zn-ace-3ap) and bis(acesulfamato-O)bis(benzotriazole)zinc(II) (C20H18N8O8S2Zn, Zn-ace-bta), were synthesized and characterized by single crystal X-ray diffraction, FT-IR spectroscopy, elemental analysis and thermal analysis techniques(TGA, DTA, DTG). The first compound, Zn-ace-3ap, crystallizes in triclinic space group P1 with parameters a?=?7.978 (7) Å, b?=?9.907 (6) Å, c?=?15.778 (14) Å, ??=?78.24° (2), ??=?81.22° (4), ??=?75.99° (2), Z?=?2 and The second compound, Zn-ace-bta, crystallizes in monoclinic space group C2/c with parameters a?=?19.879 (3) Å, b?=?9.3637 (13) Å, c?=?14.0852 (18) Å, ??=?105.483° (4), Z?=?4. The biological activities of the synthesized complexes were appraised through disk diffusion method as antibacterial, antimicrobial and antifungal in DMSO. Enterococcus faecalis (ATCC-29212), Staphylococcus aureus (ATCC-25923) as gram-positive bacteria, Pseudomonas aeroginosa (ATCC-27853) and Escherichia coli (ATCC-25922) as gram-negative bacteria, and Candida albicans (ATCC-10231) as fungus were grown with a view to investigate the antimicrobial effects of the complexes.

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