The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
UNIV SAO PAULO
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Ischemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol.
Açıklama
Anahtar Kelimeler
Free Radical, Antioxidant, Geraniol, Ischemia Reperfusion, Kidney
Kaynak
Brazilian Journal of Pharmaceutical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
Sayı
Künye
Danış, S., Can, S., Yıldız, F., Yılmaz, I. T., Canbek, M., & Yaylacı, A. Ö. (2023). The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats. Brazilian Journal of Pharmaceutical Sciences, 59, e21248.
