The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats

dc.contributor.authorDanış, Seren
dc.contributor.authorCan, Senanur
dc.contributor.authorYıldız, Fatma
dc.contributor.authorTan Yılmaz, Işıl
dc.contributor.authorCanbek, Mediha
dc.contributor.authorÖzmen Yaylacı, Ayşe
dc.date.accessioned2024-02-01T10:50:19Z
dc.date.available2024-02-01T10:50:19Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractIschemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-02-01T10:50:19Z No. of bitstreams: 1 ayse-ozmen-yaylaci2023.pdf: 1121409 bytes, checksum: 21bcb972ab7d5b4d740d0884f16ce2a6 (MD5)en
dc.description.provenanceMade available in DSpace on 2024-02-01T10:50:19Z (GMT). No. of bitstreams: 1 ayse-ozmen-yaylaci2023.pdf: 1121409 bytes, checksum: 21bcb972ab7d5b4d740d0884f16ce2a6 (MD5) Previous issue date: 2023en
dc.identifier.citationDanış, S., Can, S., Yıldız, F., Yılmaz, I. T., Canbek, M., & Yaylacı, A. Ö. (2023). The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats. Brazilian Journal of Pharmaceutical Sciences, 59, e21248.
dc.identifier.doi10.1590/s2175-97902023e21248
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/s2175-97902023e21248
dc.identifier.urihttps://hdl.handle.net/11491/8780
dc.identifier.wosWOS:000975235800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzmen Yaylacı, Ayşe
dc.language.isoen
dc.publisherUNIV SAO PAULO
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFree Radicalen_US
dc.subjectAntioxidanten_US
dc.subjectGeraniolen_US
dc.subjectIschemia Reperfusionen_US
dc.subjectKidneyen_US
dc.titleThe Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats
dc.typeArticle

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