Thiol-disulfide parameters in recurrent aphthous stomatitis: A cross-sectional study

Basit Öğe Kaydı
dc.contributor.authorKaradeniz, TB
dc.contributor.authorÖztekin, A
dc.contributor.authorÖztekin, C
dc.contributor.authorŞenel, E
dc.contributor.authorSavcı, Ü
dc.contributor.authorNeşelioğlu, S
dc.contributor.authorErel, Ö
dc.date.accessioned2026-03-31T13:21:01Z
dc.date.available2026-03-31T13:21:01Z
dc.date.issued2025
dc.description.abstractBackground Recurrent aphthous stomatitis (RAS) is an idiopathic inflammatory condition of the oral mucosa, affecting approximately one-fifth of the population. Oxidative stress (OS) has recently been suggested to contribute to the etiopathogenesis of RAS. Thiols are potent antioxidants that play vital roles against oxidation. This study aimed to determine how OS contributes to the pathophysiology of RAS by analyzing the thiol/disulfide parameters. Methods This cross-sectional study was conducted with a total of 67 participants (31 patients with clinically diagnosed RAS and 36 healthy, age- and gender- matched controls) at a university hospital from January 2022 to June 2023. Blood samples were taken from patients during the active ulcer phase. Native thiol, total thiol, and disulfide levels were measured in the serum of patients and controls. The ratios of disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated. The parameters were compared between the groups. Results No significant differences were found between the patient and control groups regarding the calculated thiol/disulfide homeostasis parameters. A significant negative correlation was observed between age and total thiol (P < .001, r = - .572). Conclusions Although OS is widely believed to play a pivotal role in the pathogenesis of RAS, conflicting findings in the literature suggest that the underlying mechanisms may be more complex and multifaceted. Therefore, more comprehensive studies are needed to clarify the oxidant and antioxidant mechanisms in RAS.
dc.identifier.doi10.1186/s12903-025-07373-5
dc.identifier.issn1472-6831
dc.identifier.issue1
dc.identifier.pmid41272560
dc.identifier.urihttp://dx.doi.org/10.1186/s12903-025-07373-5
dc.identifier.urihttps://hdl.handle.net/11491/9463
dc.identifier.volume25
dc.identifier.wosWOS:001648789500001
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofBMC ORAL HEALTH
dc.subjectMinor
dc.subjectStomatitis, aphthous
dc.subjectOxidative stress
dc.subjectAntioxidants
dc.subjectThiols
dc.subjectDisulfide
dc.titleThiol-disulfide parameters in recurrent aphthous stomatitis: A cross-sectional study
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu