Targeted agents in ovarian carcinoma

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dc.contributor.authorÖz, Murat
dc.contributor.authorSelçuk, İlker
dc.contributor.authorArık, Zafer
dc.contributor.authorGüngör, Tayfun
dc.date.accessioned2019-07-17T07:35:24Z
dc.date.available2019-07-17T07:35:24Z
dc.date.issued2016en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.descriptionresearch
dc.description.abstractGynecologic malignancies take an important part in female cancers. Ovarian cancer is the second most common gynecologic cancer with the highest mortality rate in developed countries. Most of the patients need an adjuvant chemotherapy regimen after the initial surgery. Despite their suppressive effect on tumor cells, much toxicity on healthy cells could be seen with these standard chemotherapeutics. In that manner a new way of tumor cell disruption with less toxicity and cancer selective effect is needed, which is called targeted therapy. Moreover this approach could prevent chemo-resistance and increase chemosensitivity of the disease. Primary cytoreductive surgery with platinum based chemotherapy shape the initial management of these tumors. However, recently we are on the edge of molecular therapy for this cancer. In this setting we need to identify a dominant biological pathway for tumor progression and discover a functional and structural molecule within this pathway. The new therapeutic modalities with targeted molecules should build up new perspectives insight tumor cell behaviour. Agents against angiogenesis and receptors of growth factors in addition to signalling cascades and intracellular enzymes could shape the individual treatment protocols for cancer survivors.
dc.identifier.citationÖz, M., Selçuk, İ., Arık, Z., Güngör, T. (2016). Targeted agents in ovarian carcinoma. Medicine Science, 5(2), 547-561.
dc.identifier.doi10.5455/medscience.2015.04.8351
dc.identifier.endpage561en_US
dc.identifier.issn2147-0634
dc.identifier.issue2en_US
dc.identifier.startpage547en_US
dc.identifier.urihttps://hdl.handle.net/11491/3645
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherSociety of TURAZ BİLİM
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTargeted Therapyen_US
dc.subjectOvarian Carcinomaen_US
dc.subjectChemotherapyen_US
dc.titleTargeted agents in ovarian carcinoma
dc.typeArticle

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