Investigation of the Protective and Therapeutic Effects of Ginger (Zingiber officinale) Extracts on Neuroinflammatory, Motor and Cognitive Impairments Caused by Mild Traumatic Brain Injury Model

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dc.contributor.authorAkçay, G
dc.contributor.authorÖzdemir, F
dc.contributor.authorÖzkınalı, S
dc.contributor.authorDemirdöğen, F
dc.contributor.authorYılmaz, A
dc.date.accessioned2026-03-31T13:21:03Z
dc.date.available2026-03-31T13:21:03Z
dc.date.issued2025
dc.description.abstractAIM: To examine the effects of phenolic compound-rich ginger extract on motor and cognitive functions as well as cytokine levels in the mild traumatic brain injury (mTBI) model. MATERIAL and METHODS: The mTBI model was modeled employing the Marmarou method. The Ginger group rats were i.p. administered 50 mg/kg of ginger extract. The Ginger+traumatic brain injury (TBI) group rats were i.p. administered 50 mg/kg of ginger extract two days before the TBI was induced. The control and TBI+Ginger group rats were provided ginger extract (50 mg/ kg i.p.) immediately after the TBI. Motor and cognitive behavioral experiments were performed. The cytokine levels were analyzed using the ELISA method. RESULTS: While TBI caused a decline in motor and cognitive functions, significant enhancements of these functions were observed in the Ginger+TBI and TBI+Ginger groups because of the ginger treatment. While TBI induced an increased hippocampal cytokine level, significant decreases were detected in the Ginger+TBI and TBI+Ginger groups following ginger treatment. CONCLUSION: The study findings revealed that phenolic compound-rich ginger extract may exert therapeutic effects on cytokine levels in the mTBI model.
dc.identifier.doi10.5137/1019-5149.JTN.46057-23.7
dc.identifier.issn1019-5149
dc.identifier.issue2
dc.identifier.pmid40129204
dc.identifier.urihttp://dx.doi.org/10.5137/1019-5149.JTN.46057-23.7
dc.identifier.urihttps://hdl.handle.net/11491/9497
dc.identifier.volume35
dc.identifier.wosWOS:001461201200008
dc.language.isoen
dc.publisherTURKISH NEUROSURGICAL SOC
dc.relation.ispartofTURK NEUROSURG
dc.subjectGinger
dc.subjectCognitive function
dc.subjectNeuroprotective treatment
dc.subjectTherapeutic treatment
dc.subjectMild traumatic brain injury
dc.titleInvestigation of the Protective and Therapeutic Effects of Ginger (Zingiber officinale) Extracts on Neuroinflammatory, Motor and Cognitive Impairments Caused by Mild Traumatic Brain Injury Model
dc.typeArticle

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