Impact of Obesity on Subarachnoid Hemorrhage-Induced Cerebral Vasospasm: An Experimental Rat Model

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dc.contributor.authorAlpergin, BC
dc.contributor.authorGökalp, E
dc.contributor.authorKılınç, MC
dc.contributor.authorAras, N
dc.contributor.authorErsöz, CC
dc.contributor.authorDoğan, İ
dc.date.accessioned2026-03-31T13:21:13Z
dc.date.available2026-03-31T13:21:13Z
dc.date.issued2025
dc.description.abstractAIM: To investigate the effect of obesity on the severity of cerebral vasospasm after subarachnoid hemorrhage. MATERIAL and METHODS: In this study, six experimental groups, each consisting of 10 rats, were defined (60 rats in total). Groups 1 and 2 comprised rats with normal body weight, Groups 3 and 4 comprised obese rats, and Groups 5 and 6 comprised rats that returned to normal body weight after being obese. Rats in Groups 2, 4, and 6, represented the study groups, and experimental SAH was induced in them. Group 1, 3 and 5 was determined as the control group. Basilar artery lumen areas and wall thicknesses were measured and compared in all groups. RESULTS: The luminal area of the basilar artery was significantly reduced in Groups 2, 4, and 6, than in Groups 1, 3, and 5, respectively. This indicated the development of vasospasm. No significant differences were found in the basilar artery luminal areas and wall thicknesses between Groups 1, 3, and 5. However, there were significant differences between Groups 2, 4, and 6. The basilar artery luminal area was significantly smaller in Group 4 than in Groups 2 and 6. There was no significant difference in basilar artery luminal areas between Groups 2 and 6. CONCLUSION: This experimental study elucidated that the severity of vasospasm subsequent to subarachnoid hemorrhage escalated in the presence of obesity, and conversely, a return to normal body weight mitigated the severity of cerebral vasospasm. Prospective clinical investigations ought to scrutinize the correlation between obesity and vasospasm, emphasizing the necessity for vigilant monitoring of vasospasm post-SAH in obese patients.
dc.identifier.doi10.5137/1019-5149.JTN.47241-24.3
dc.identifier.issn1019-5149
dc.identifier.issue1
dc.identifier.pmid39651885
dc.identifier.urihttp://dx.doi.org/10.5137/1019-5149.JTN.47241-24.3
dc.identifier.urihttps://hdl.handle.net/11491/9621
dc.identifier.volume35
dc.identifier.wosWOS:001414307800010
dc.language.isoen
dc.publisherTURKISH NEUROSURGICAL SOC
dc.relation.ispartofTURK NEUROSURG
dc.subjectObesity
dc.subjectCerebral vasospasm
dc.subjectSubarachnoid hemorrhage
dc.subjectDelayed cerebral ischemia
dc.titleImpact of Obesity on Subarachnoid Hemorrhage-Induced Cerebral Vasospasm: An Experimental Rat Model
dc.typeArticle

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