İndol-3-karboksialdehit ve indol-5-karboksialdehitten başlayarak yeni tiyadiazol türevli Schiff bazlarının eldesi
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Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hitit Üniversitesi Fen Bilimleri Enstitüsü
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada, literatürde yer almayan indol ve tiyadiazol grubu içeren ve biyolojik olarak aktif olabileceği düşünülen yeni Schiff bazlarının eldesi amaçlanmıştır. Bu amaç doğrultusunda toplamda 10 farklı, indol-3-karboksialdehit ve indol-5-karboksialdehit ile 1,3,4-tiyadiazol bileşiklerinin (2,5-dimetoksi sinnamik asit, 3,4-dimetoksi sinnamik asit, 2-nitro sinnamik asit, 3-nitro sinnamik asit, 4-nitro sinnamik asit) kondenzasyonu sonucu Schiff bazları sentezlenmiştir. Sentezlenen bileşiklerin kimyasal yapıları IR, UV-Vis, 1H-NMR, 13C-NMR, spektroskopik yöntemleri ve elemental analiz ile incelenmiştir.
In this study, it was aimed to obtain new Schiff bases which contain indole and thiadiazole groups which are not included in the literature and which are thought to be biologically active. For this purpose, a total of 10 different Schiff base derivatives were synthesized by the condensation reaction by indole-3-carboxyaldehyde and indole-5-carboxyaldehyde with 1,3,4-thiadiazole compounds (2,5-dimethoxy cinnamic acid, 3,4-dimethoxy cinnamic acid, 2-nitro cinnamic acid). The chemical structures of the synthesized compounds were analyzed by IR, UV-Vis, 1H-NMR, 13C-NMR and elemental analysis methods.
In this study, it was aimed to obtain new Schiff bases which contain indole and thiadiazole groups which are not included in the literature and which are thought to be biologically active. For this purpose, a total of 10 different Schiff base derivatives were synthesized by the condensation reaction by indole-3-carboxyaldehyde and indole-5-carboxyaldehyde with 1,3,4-thiadiazole compounds (2,5-dimethoxy cinnamic acid, 3,4-dimethoxy cinnamic acid, 2-nitro cinnamic acid). The chemical structures of the synthesized compounds were analyzed by IR, UV-Vis, 1H-NMR, 13C-NMR and elemental analysis methods.
Açıklama
Anahtar Kelimeler
İndol, Tiyadiazol, Schiff Bazı, Spektroskopi, Indole, Thiadiazole, Schiff Bases, Spectroscopy
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Tosun, T. (2020). İndol-3-karboksialdehit ve indol-5-karboksialdehitten başlayarak yeni tiyadiazol türevli Schiff bazlarının eldesi (Yüksek Lisans Tezi).
