Optimization of separation of several sulfonamides in acetonitrile-water binary mixtures by using symmetry shield RP-8 column

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dc.authorid0000-0002-0275-3941
dc.authorid0000-0002-5807-3494
dc.contributor.authorŞanlı, Senem
dc.contributor.authorŞanlı, Nurullah
dc.contributor.authorGökmeşe, Faruk
dc.contributor.authorGökmeşe, Ebru
dc.contributor.authorÇubuk Demiralay, Ebru
dc.date.accessioned2019-11-01T12:47:25Z
dc.date.available2019-11-01T12:47:25Z
dc.date.issued2009
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.descriptionresearch
dc.description.abstractIn this work, the proportion of organic modifier of the hydro-organic mobile phase was optimized in order to separate twelve compounds namely sulfaguanidine, sulfanilamide, sulfadiazine, sulfathiazole, sulfamethazine, sulfamerazine, sulfamethoxypyridazine, sulfamonomethoxyne, sulfachloropyridazine, sulfadoxine, sulfafurazole and dapson using Symmetry Shield RP-8 Column. Mobile phase was optimized by establishing relationships between retention parameters and Reichardt’s RTN scale of solvent polarity. In addition, selectivity (α) and resolution (RS) values were used in order to establish a general model relating elution behavior of substances with the composition of mobile phase. Logarithm of retention factor corresponding to pure water, log kw, which is the most commonly employed chromatographic hydrophobicity parameter determined by using chromatographic data.
dc.identifier.citationŞanlı, S., Nurullah, Ş., Gökmeşe, F., Gökmeşe, E., Demiralay, E. Ç. (2009). Optimization of separation of several sulfonamides in acetonitrile-water binary mixtures by using symmetry shield RP-8 column. Hacettepe Journal of Biology and Chemistry, 37(2), 103-110.
dc.identifier.endpage110en_US
dc.identifier.issn1303-5002
dc.identifier.issue2en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://hdl.handle.net/11491/4947
dc.identifier.volume37en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherHacettepe University
dc.relation.ispartofHacettepe Journal of Biology and Chemistry
dc.relation.publicationcategory[Belirlenecek]
dc.rights[Belirlenecek]
dc.subjectSulfonamidesen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectMobile Phase Optimizationen_US
dc.titleOptimization of separation of several sulfonamides in acetonitrile-water binary mixtures by using symmetry shield RP-8 column
dc.typeArticle

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