Ailevi akdeniz ateşi hastalığı olanlarda serum prolidaz enzim aktivitesi ile endotel disfonksiyonu ve kardiyak fonksiyonlar arasında ilişkinin araştırılması
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Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hitit Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, Ailevi Akdeniz Ateşi (AAA) olanlarda serum prolidaz enzim aktivitesi (SPEA) ile endotel disfonksiyonu (ED) ve kardiyak fonksiyonlar arasında ilişkinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Bu klinik kesitsel çalışmaya 18-65 yaş arasında toplam 112 katılımcı (ataksız dönemde AAA hastaları [n=73], kronik hastalığı olmayan kontrol grubu [n=39]) dahil edildi. Ekokardiyografi ile ED için akış aracılı dilatasyon (FMD), sol ventrikül diyastolik disfonksiyonu (SVDD) için endotelyal deselerasyon zamanı (EDT) ve subklinik ateroskleroz ölçümü için karotis intima media kalınlığı (KİMK) bakıldı. Eş zamanlı SPEA ölçümleri için kan örnekleri alındı. Bulgular: AAA tanısı olan 73 kişi, sağlıklı 39 kişi olmak üzere toplamda 112 kişi çalışmaya dahil edildi. Hasta gurubunda eritrosit sedimentasyon hızı (P=0,005), lökosit (P=0,029), C-reaktif protein ve fibrinojen (P<0,001) kontrol grubuna göre istatistiksel olarak anlamlı şekilde daha yüksek saptadık. SPEA hasta grubunda kontrol gurubuna istatistiksel olarak daha yüksekti (P=0,032). Hastalarda kontrol grubuna göre FMD istatistiksel olarak daha düşük, KİMK ve SVDD gösteren parametrelerden biri olan EDT istatistiksel olarak anlamlı şekilde daha yüksek bulundu (P<0,001). Hasta grubunda bakılan SPEA ile ED varlığı, SVDD varlığı ve artmış KİMK arasındaki ilişkinin değerlendirildiği tek değişkenli lojistik regresyon analizinde, artmış KİMK (P=0,048) dışında istatistiksel anlamlılık saptanmadı. Sonuç: AAA olan hastalarda SPEA yüksek bulundu. ED, SVDD ve subklinik ateroskleroz gelişme riski normal popülasyona göre daha yüksek olabilir. Subklinik ateroskleroz ile artmış SPEA ilişkisi olabilir, ancak ED ve SVDD ile SPEA arasında ilişki tespit edilmedi. Anahtar Kelimeler: Ailevi Akdeniz Ateşi, Serum prolidaz enzim aktivitesi, Endotel disfonksiyon, Sol ventrikül diyastolik disfonksiyon, Subklinik ateroskleroz
Aim: The aim of this study was to investigate the relationship between serum prolidase enzyme activity (SPEA) and endothelial dysfunction (ED) and cardiac functions in individuals with Familial Mediterranean fever (FMF). Material and Method: A total of 112 participants aged 18-65 years FMF patients in the attack-free period (n=73) and a control group without chronic diseases (n=39) were included in this cross-sectional clinical study. Echocardiography was used to assess flow-mediated dilation (FMD) for ED, endothelial deceleration time (EDT) for left ventricular diastolic dysfunction (LVDD), and carotid intima-media thickness (CIMT) for measuring subclinical atherosclerosis. Simultaneous SPEA measurements were obtained from blood samples. Results: Patients with FMF (n=73) and the control group (n=39) were included. In the patient group, erythrocyte sedimentation rate (P=0.005), leukocyte count (P=0.029), C-reactive protein, and fibrinogen (P<0.001) were statistically significantly higher compared to the control group. SPEA was also statistically higher in the patient group compared to the control group (P=0.032). Parameters indicating ED, CIMT, and one of the parameters indicating LVDD, EDT, were statistically significantly higher in patients compared to the control group (P<0.001). In the univariate logistic regression analysis evaluating the relationship between SPEA and the presence of ED, the presence of LVDD, and increased CIMT in the patient group, apart from increased CIMT (P=0.048), no significance was found. Conclusion: Higher SPEA was found in patients with FMF. The risk of developing ED, LVDD, and subclinical atherosclerosis is higher in patients compared to the normal population. There may be an association between subclinical atherosclerosis and increased SPEA, but no relationship was found between SPEA and ED or LVDD. Keywords: Endothelial dysfunction Familial Mediterranean Fever, Left ventricular diastolic dysfunction, Serum prolidase enzyme activity, Subclinical atherosclerosis
Aim: The aim of this study was to investigate the relationship between serum prolidase enzyme activity (SPEA) and endothelial dysfunction (ED) and cardiac functions in individuals with Familial Mediterranean fever (FMF). Material and Method: A total of 112 participants aged 18-65 years FMF patients in the attack-free period (n=73) and a control group without chronic diseases (n=39) were included in this cross-sectional clinical study. Echocardiography was used to assess flow-mediated dilation (FMD) for ED, endothelial deceleration time (EDT) for left ventricular diastolic dysfunction (LVDD), and carotid intima-media thickness (CIMT) for measuring subclinical atherosclerosis. Simultaneous SPEA measurements were obtained from blood samples. Results: Patients with FMF (n=73) and the control group (n=39) were included. In the patient group, erythrocyte sedimentation rate (P=0.005), leukocyte count (P=0.029), C-reactive protein, and fibrinogen (P<0.001) were statistically significantly higher compared to the control group. SPEA was also statistically higher in the patient group compared to the control group (P=0.032). Parameters indicating ED, CIMT, and one of the parameters indicating LVDD, EDT, were statistically significantly higher in patients compared to the control group (P<0.001). In the univariate logistic regression analysis evaluating the relationship between SPEA and the presence of ED, the presence of LVDD, and increased CIMT in the patient group, apart from increased CIMT (P=0.048), no significance was found. Conclusion: Higher SPEA was found in patients with FMF. The risk of developing ED, LVDD, and subclinical atherosclerosis is higher in patients compared to the normal population. There may be an association between subclinical atherosclerosis and increased SPEA, but no relationship was found between SPEA and ED or LVDD. Keywords: Endothelial dysfunction Familial Mediterranean Fever, Left ventricular diastolic dysfunction, Serum prolidase enzyme activity, Subclinical atherosclerosis
Açıklama
Hitit Üniversitesi, Tıp Fakültesi
Anahtar Kelimeler
Ailevi Akdeniz Ateşi, Serum prolidaz enzim aktivitesi, Endotel disfonksiyon, Sol ventrikül diyastolik disfonksiyon, Subklinik ateroskleroz, Endothelial dysfunction Familial Mediterranean Fever, Left ventricular diastolic dysfunction, Serum prolidase enzyme activity, Subclinical atherosclerosis, Ailevi Akdeniz Ateşi, Serum prolidaz enzim aktivitesi, Endotel disfonksiyon, Sol ventrikül diyastolik disfonksiyon, Subklinik ateroskleroz, Endothelial dysfunction Familial Mediterranean Fever, Left ventricular diastolic dysfunction, Serum prolidase enzyme activity, Subclinical atherosclerosis
