Dietary hempseed and cardiovascular health: nutritional composition, mechanisms and comparison with other seeds

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dc.contributor.authorKaçar, ÖF
dc.contributor.authorKose, T
dc.contributor.authorKaçar, HK
dc.date.accessioned2026-03-31T13:21:04Z
dc.date.available2026-03-31T13:21:04Z
dc.date.issued2025
dc.description.abstractCardiovascular disease (CVD) remains the leading cause of global mortality, with dietary habits playing a significant role in its prevention and management. Hempseed (Cannabis sativa L.) has gained recognition as a functional food due to its rich nutritional profile, including high-quality plant proteins, optimal omega-6 to omega-3 fatty acid ratios, and a variety of bioactive compounds such as tocopherols, phytosterols, and polyphenols. This review critically evaluates the potential cardioprotective effects of hempseed, focusing on its impact on lipid metabolism, inflammation, oxidative stress, and other cardiometabolic markers. Preclinical studies suggest that hempseed can improve lipid profiles, reduce blood pressure, and reduce oxidative stress and inflammation, though clinical evidence remains limited and findings from animal models may not directly translate to human cardiovascular benefits due to physiological differences between species. This review further evaluates hempseed's potential in cardiovascular disease prevention and highlights its potential advantages when compared with other widely consumed seeds (flaxseed and chia seeds), emphasizing its unique fatty acid composition, optimal omega-6 to omega-3 ratio, and diverse bioactive compounds. Despite the promising findings, there is a need for long-term randomized controlled trials to establish the efficacy and safety of hempseed in diverse populations. This review emphasizes the potential of hempseed as a dietary intervention for CVD prevention and calls for further research to optimize its use in clinical and public health settings.
dc.identifier.doi10.3389/fnut.2025.1669375
dc.identifier.issn2296-861X
dc.identifier.pmid41132555
dc.identifier.urihttp://dx.doi.org/10.3389/fnut.2025.1669375
dc.identifier.urihttps://hdl.handle.net/11491/9518
dc.identifier.volume12
dc.identifier.wosWOS:001596953300001
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.relation.ispartofFRONT NUTR
dc.subjecthempseed
dc.subjectCannabis sativa L.
dc.subjectcardiovascular disease
dc.subjectfunctional food
dc.subjectinflammation
dc.subjectoxidative stress
dc.titleDietary hempseed and cardiovascular health: nutritional composition, mechanisms and comparison with other seeds
dc.typeReview

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