A Systematic Review and Analysis of Brucella Endocarditis Cases

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dc.contributor.authorBaşaran, S
dc.contributor.authorŞimşek-Yavuz, S
dc.contributor.authorSarıcaoğlu, ME
dc.contributor.authorAydın, M
dc.contributor.authorAygün, G
dc.contributor.authorAzap, A
dc.contributor.authorAzap, Ö
dc.contributor.authorBenli, A
dc.contributor.authorDemirtürk, N
dc.contributor.authorErgönül, Ö
dc.contributor.authorKocagül-Çelikbağ, A
dc.contributor.authorKuşçu, F
dc.contributor.authorÖzger, S
dc.contributor.authorKutlu, SS
dc.contributor.authorTürker, N
dc.contributor.authorTürkoğlu-Yılmaz, E
dc.date.accessioned2026-03-31T13:21:10Z
dc.date.available2026-03-31T13:21:10Z
dc.date.issued2025
dc.description.abstractEndocarditis is the most common cause of death from brucellosis. The information used to guide the management of cases with Brucella endocarditis has relied on case reports/ series. Risk factors related to death and other adverse outcomes in patients with Brucella endocarditis were identified by an individual-patient data analysis of all reported Brucella endocarditis cases in the literature. The keywords Bruce and endocard were used to search articles published until July 2022 on PubMed and ULAKBIM databases. Case reports/series containing patients with endocarditis caused by Brucella spp., aged >= 17 years, and with data on antimicrobial or surgical treatment were included in the study. Epidemiological, clinical, laboratory, and treatment characteristics and outcomes of 273 cases from 86 eligible articles were recorded. It was found that male gender, a Wright serum tube agglutination (STA) titer of >= 1/1280 on admission, development of heart failure due to endocarditis were independent risk factors that increase mortality, while the usage of aminoglycoside and cardiac surgical intervention for endocarditis were factors reducing mortality. Including streptomycin or gentamicin in the treatment regimen may benefit patients with Brucella endocarditis. Valve surgery could be life-saving in patients with Brucella endocarditis. An STA titer of >= 1/1280, which probably reflects long-term and advanced disease, may be used as a marker for increased mortality. However, additional and more reliable studies are needed to define the most appropriate management approach in diagnosing and treating cases with Brucella endocarditis due to the low quality of the current evidence.
dc.identifier.doi10.14744/AnatolJCardiol.2025.4259
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3
dc.identifier.pmid40032639
dc.identifier.urihttp://dx.doi.org/10.14744/AnatolJCardiol.2025.4259
dc.identifier.urihttps://hdl.handle.net/11491/9559
dc.identifier.volume29
dc.identifier.wosWOS:001456364800003
dc.language.isoen
dc.publisherKARE PUBL
dc.relation.ispartofANATOL J CARDIOL
dc.subjectBrucella
dc.subjectendocarditis
dc.subjectmortality
dc.titleA Systematic Review and Analysis of Brucella Endocarditis Cases
dc.typeReview

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