THE EFFECT OF BARLEY GRASS ON ANTIOXIDANT CAPACITY AND DNA DAMAGE IN RAT WITH RENAL FAILURE

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dc.authoridComba, Arzu / 0000-0001-9462-8998
dc.authorwosidComba, Arzu / AAI-4424-2021
dc.contributor.authorComba, Bahat
dc.contributor.authorMis, Leyla
dc.contributor.authorUslu, Sema
dc.contributor.authorComba, Arzu
dc.date.accessioned2021-11-01T14:58:26Z
dc.date.available2021-11-01T14:58:26Z
dc.date.issued2017
dc.department[Belirlenecek]
dc.description.abstractThis study was aimed to search the effect of barley grass (BG) on the Total Antioxidant (TAS)-Oxidant Status (TOS) and DNA damage (8OHdG) in rat with renal failure. The rats which are used in the study were randomly divided into 4 groups that each of has 8 rats: Control (C) group; injected i.p. with physiological saline once a day for 7 days, GM group; Gentamicin (80 mg/kg/day) was injected i.p. for 7 days, BG group; was given oral BG (250 mg/kg/day) for 4 weeks, GM+BG group was injected gentamicin (80 mg/kg/day) with i.p. for 7 days and BG (250 mg/kg/day) was given by oral for 4 weeks. After from the process of experiment for 4 weeks, blood sample and kidney tissue were taken. The analyses of urea and creatinine were done by autoanalyser; TAS, TOS levels by colorimetric kits; 8OHdG level by ELISA kits in serum. The kidney tissues were examined histologically. In the GM+BG group was statistically decreased levels of urea, creatinine, TOS (p<0.05) and OSI (p<0.01) compared to GM group. In the group of BG was determined the levels of TAS p<0.05 statistically increased other groups. The statistical significance was not found in the level of serum 8OHdG differences between the groups. BG decreased widespread damage to the renal glomerulus and proximal tubulus. As a result, adverse effects of high dose gentamicin application such as kidney damage can be reduced when used barley grass.
dc.description.sponsorshipYuzuncu Yil University Grant CommissionYuzuncu Yil University [YYUBAP- 2015-VF-B011]en_US
dc.description.sponsorshipThis study was supported by Yuzuncu Yil University Grant Commission of research numbered with YYUBAP- 2015-VF-B011 and it was presented at International Congress on Applied Biological Sciences, September 16-20, 2015, Skopje-Makedonya.en_US
dc.identifier.endpage6140en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue10en_US
dc.identifier.startpage6135en_US
dc.identifier.urihttps://hdl.handle.net/11491/6644
dc.identifier.volume26en_US
dc.identifier.wosWOS:000413499500057
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbarley grassen_US
dc.subjectDNA damageen_US
dc.subjectgentamicinen_US
dc.subjectkidneyen_US
dc.subjectTASen_US
dc.subjectTOSen_US
dc.titleTHE EFFECT OF BARLEY GRASS ON ANTIOXIDANT CAPACITY AND DNA DAMAGE IN RAT WITH RENAL FAILURE
dc.typeArticle

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