Tau protein hyperphosphorylation in children with cerebral palsy with sleep disorders

dc.contributor.authorDoğan, Ayşe Gülşen
dc.contributor.authorÇetin, İhsan
dc.date.accessioned2024-01-30T07:15:14Z
dc.date.available2024-01-30T07:15:14Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractAims: In this study, we aimed to evaluate the relationship between sleep disorder and serum tau protein levels in children with cerebral palsy. Methods: The sample was selected among children aged 6-10 years who applied to our physical medicine and rehabilitation outpatient clinic. In order to evaluate sleep quality, the Pittsburgh Sleep Quality Index (PSQI) questionnaire was recorded by asking parents of all participants. Children with CP who had a Pittsburgh Sleep Quality Index value above 5 were determined as the sleep disorder group. We recruited 27 children with CP and sleep disorders in the first patient group (Group 1), 27 children with CP but without sleep disorders in the second group (Group 2). The third group (Group 3), which was the healthy group, included 27 children without any disease. We also recorded the age of children at diagnosis, risk factors for CP (premature, prolonged birth, etc.), CP type, gross motor function classification system (GMFCS), botox application, orthoses usage, maternal age at birth, and additional problems. We measured total tau protein (T-tau) and phosphorylated tau protein (P-tau) levels in blood samples through a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). The correlation between tau protein and PSQI values was examined. Results: Maternal age (p=0.001), gross motor function classification system (GMFCS) (p=0.001), and pittsburgh sleep quality index (PSQI) (p=0.001) were significantly higher in the group with sleep disorders. There was a statistically significant difference between the groups in terms of serum T-Tau and P-tau protein levels (T-tau p=0.003, P-tau p=0.004). In the group sleep disorders, PSQI was significantly correlated with T-tau (r=0.499) and P-tau (r=0.473). Conclusion: This study shows that tau protein levels are higher in CP patients with sleep disorders than in participants without sleep disorders. In the correlation analyzes, a positive and significant correlation was observed between PSQI values and T-tau and P-tau in sleep disorders groups, and no correlation was found in without sleep disorders.
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dc.description.provenanceApproved for entry into archive by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2024-01-30T07:15:14Z (GMT) No. of bitstreams: 1 ihsan-cetin2023.pdf: 219524 bytes, checksum: 0c4e57428e57fbc6160b75177d50c2ee (MD5)en
dc.description.provenanceMade available in DSpace on 2024-01-30T07:15:14Z (GMT). No. of bitstreams: 1 ihsan-cetin2023.pdf: 219524 bytes, checksum: 0c4e57428e57fbc6160b75177d50c2ee (MD5) Previous issue date: 2023en
dc.identifier.citationDoğan, A. G., & Çetin, İ. Tau protein hyperphosphorylation in children with cerebral palsy with sleep disorders. Anatolian Current Medical Journal, 5(3), 270-274.
dc.identifier.doi10.38053/acmj.1309367
dc.identifier.issn2718-0115
dc.identifier.urihttps://doi.org/10.38053/acmj.1309367
dc.identifier.urihttps://hdl.handle.net/11491/8754
dc.institutionauthorDoğan, Ayşe Gülşen
dc.institutionauthorÇetin, İhsan
dc.language.isoen
dc.publisherMediHealth Academy
dc.relation.ispartofAnatolian Current Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCerebral palsyen_US
dc.subjectTau proteinen_US
dc.subjectPhosphorylated tau proteinen_US
dc.subjectSleep disordersen_US
dc.titleTau protein hyperphosphorylation in children with cerebral palsy with sleep disorders
dc.typeArticle

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