MRI-Based Evaluation of Pituitary Size and Volume in Children with Idiopathic Growth Hormone Deficiency

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dc.contributor.authorKaba, İ
dc.contributor.authorYanarateş, G
dc.contributor.authorKendirci, HNP
dc.date.accessioned2026-03-31T13:21:12Z
dc.date.available2026-03-31T13:21:12Z
dc.date.issued2025
dc.description.abstractBackground:Growth hormone deficiency (GHD) is the most common cause of pathological short stature of endocrine origin. Among the causes of pathological short stature, pathologies in the hypothalamic-pituitary region, especially the pituitary gland, have an important place, and imaging the region with pituitary magnetic resonance imaging (MRI) is a frequently used method in the diagnosis process and guides the diagnosis and treatment process. It is known that hypoplasia or aplasia of the pituitary gland, which plays a role in the synthesis and release of many hormones in addition to GH, causes short stature. Aim:This study aims to evaluate pituitary size and volume as potential diagnostic markers in children with idiopathic growth hormone deficiency (IGHD) compared with healthy controls. Methods:The study included children who presented to our hospital's pediatric endocrinology outpatient clinic with complaints of short stature/growth retardation and was diagnosed with IGHD, for whom MRI of the pituitary had been performed. Pituitary MRI examinations were retrospectively reviewed to measure the, adenohypophysis height, anterior-posterior diameter, width, and volume, and these measurements were compared with those of an age- and gender-matched control group. Results:A total of 55 patients diagnosed with IGHD were included, with a mean chronological age of 9.8 +/- 3.4 years, of whom 58.2% (n = 32) were male. The control group consisted of 42 healthy children with a mean chronological age of 9.3 +/- 3.4 years, with 47.6% (n = 20) being male. No significant differences in age and gender were found between the groups (P = 0.523, P = 0.306, respectively). Although the adenohypophysis height, anterior-posterior diameter, width, and volume of patients with IGHD were lower than those in the control group, no statistical differences were observed between the two groups (P > 0.05). There were no differences in pituitary size and volume based on gender in either group (P > 0.05). A positive correlation was found between pituitary height, width, and volume with age, insulin-like growth factor-1 (IGF-1) standard deviations (SD), and insulin-like growth factor binding protein-3 (IGFBP-3) SD (P < 0.05), whereas no correlation was found between stimulated peak GH levels and pituitary size and volume (P > 0.05). Conclusion:We found that the size and volume of the adenohypophysis in patients with IGHD are not different from those of healthy peers; however, they showed a correlation particularly with IGF-1 and IGFBP-3 standard deviations.
dc.identifier.doi10.4103/njcp.njcp_555_24
dc.identifier.issn1119-3077
dc.identifier.issn2229-7731
dc.identifier.issue2
dc.identifier.pmid40326894
dc.identifier.urihttp://dx.doi.org/10.4103/njcp.njcp_555_24
dc.identifier.urihttps://hdl.handle.net/11491/9601
dc.identifier.volume28
dc.identifier.wosWOS:001454314800013
dc.language.isoen
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONS
dc.relation.ispartofNIGER J CLIN PRACT
dc.subjectChild
dc.subjectidiopathic growth hormone deficiency
dc.subjectMRI
dc.subjectpituitary dimensions
dc.titleMRI-Based Evaluation of Pituitary Size and Volume in Children with Idiopathic Growth Hormone Deficiency
dc.typeArticle

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