Influence of Maternal Toxoplasmosis on the Second-Trimester Aneuploidy Screening Test

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dc.contributor.authorGörkem, Ümit
dc.contributor.authorGüreser, Ayşe Semra
dc.contributor.authorToğrul, Cihan
dc.contributor.authorKarasartova, Djursun
dc.contributor.authorGüngör, Tayfun
dc.contributor.authorTaylan Özkan, Hikmet Ayşegül
dc.contributor.authorKoçak, Özgür
dc.date.accessioned2021-11-01T18:17:54Z
dc.date.available2021-11-01T18:17:54Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: With apoptosis being critical for the development and homeostasis of placental tissues, it is possible to hypothesize that accelerated trophoblastic apoptosis during pregnancy may result in a partial loss of trophoblastic activity or trophoblastic cell mass, and ultimately may alter the second-trimester screening test parameters. Thus, this study was conducted to investigate the influence of maternal toxoplasmosis on second-trimester aneuploidy screening tests. STUDY DESIGN: This retrospective study was conducted with 552 pregnant women admitted to our University Hospital. The demographic data such as maternal age and weight; and the main parameters of second-trimester aneuploidy screening test including maternal serum alpha-fetoprotein, unconjugated estriol (uE3) and human chorionic gonadotropin were analyzed with the comparison of their Toxoplasma immunoglobulin serology results. RESULTS: The mean age of the pregnant women was 27.6 (17.0 - 43.0) years, and the mean maternal weight was 65.0 (40.0 - 120.0) kg. The pregnant women with positive Toxoplasma IgG antibody had a higher mean maternal age than those with negative Toxoplasma IgG antibody (p<0.0001). No significant difference for the concentrations and MoM values of second-trimester screening test parameters in women with Toxoplasma IgM and IgG antibodies was observed (p>0.05, for all). CONCLUSION: Although IgG-seropositivity of toxoplasmosis may lead to an accelerated trophoblastic apoptosis during pregnancy, there is no significant influence on the second-trimester screening test results. There was no data regarding the unaffected population whom used for calculation of MoM, if they had toxoplasmosis in their life span.
dc.identifier.citationGorkem, U., Gureser, A. S., Togrul, C., Karasartova, D., Gungor, T., Ozkan, A. T., & Kocak, O. (2018). Influence of maternal toxoplasmosis on the second-trimester aneuploidy screening test. Gynecology Obstetrics & Reproductive Medicine, 24(2), 71-75.
dc.identifier.endpage75en_US
dc.identifier.issn1300-4751
dc.identifier.issn2602-4918
dc.identifier.issue2en_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpZME9UZzFOUT09
dc.identifier.urihttps://hdl.handle.net/11491/7758
dc.identifier.volume24en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorGörkem, Ümit
dc.institutionauthorToğrul, Cihan
dc.institutionauthorKarasartova, Djursun
dc.institutionauthorGüngör, Tayfun
dc.institutionauthorTaylan Özkan, Hikmet Ayşegül
dc.institutionauthorKoçak, Özgür
dc.language.isoen
dc.relation.ispartofGORM:Gynecology Obstetrics & Reproductive Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectToxoplasmosisen_US
dc.subjectSecond-trimesteren_US
dc.subjectAneuploidyen_US
dc.subjectTriple Testen_US
dc.titleInfluence of Maternal Toxoplasmosis on the Second-Trimester Aneuploidy Screening Test
dc.typeArticle

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