Assessing the potential of nifedipine and resveratrol to enhance ovarian viability in conjunction with detorsion treatment: A rat ovarian torsion model study

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dc.contributor.authorSezgin, A
dc.contributor.authorSert, AAE
dc.contributor.authorKaplanoğlu, GT
dc.contributor.authorKarakaya, C
dc.contributor.authorDemirdağ, E
dc.contributor.authorAkdulum, MFC
dc.contributor.authorErdem, M
dc.contributor.authorErdem, A
dc.contributor.authorÖktem, M
dc.date.accessioned2026-03-31T13:21:18Z
dc.date.available2026-03-31T13:21:18Z
dc.date.issued2025
dc.description.abstractObjective Evaluating the therapeutic effect of detorsion, resveratrol, and nifedipine on ovarian viability assessed by biochemical, histopathological and immunohistochemical parameters and markers of oxidative stress. Materials and Methods Twenty-four Sprague-Dawley rats were included in 4 groups, namely: sham operation, ischemia-reperfusion (I/R), I/R+10 mg/kg nifedipine (NIF), I/R+100 mg/kg resveratrol (RSV). In the study groups, bilateral 720 degrees ovarian torsion was performed and continued for 3 hours, followed by detorsion for another 3 hours. Thirty minutes before the detorsion, NIF and RSV groups received respective treatments. Adnexectomy was performed, and evaluations were made for the expression of anti-m & uuml;llerian hormone (AMH), vascular endothelial growth factor receptor 2 (VEGFR-2), markers of oxidative stress, and follicle counts. Blood AMH levels were measured. Results No change in AMH levels was detected. Although the expression of AMH was significantly reduced following I/R alone, it remained similar to the control group in the NIF group. Meanwhile, the RSV group exhibited slightly lower expression than the control, although it was still higher than that observed with the I/R injury group. VEGFR-2 staining was similar in the I/R and NIF groups, but reduced in the RSV group. Markers of oxidative stress were similar between groups. Primordial follicle count was lower in the untreated I/R injury group compared to the control group (p<0.05). The NIF group had more secondary follicles than the I/R injury and RSV groups (p<0.05). Conclusion Nifedipine and resveratrol treatments did not influence AMH levels and antioxidant-oxidant system parameters in rats exposed to I/R injury. However, nifedipine had a positive effect on AMH expression and secondary follicle count, and resveratrol decreased the expression of VEGFR-2 in tissues, which can be an indicator of their clinical potential.
dc.identifier.doi10.4274/tjod.galenos.2025.30161
dc.identifier.issn2149-9322
dc.identifier.issn2149-9330
dc.identifier.issue2
dc.identifier.pmid40462448
dc.identifier.urihttp://dx.doi.org/10.4274/tjod.galenos.2025.30161
dc.identifier.urihttps://hdl.handle.net/11491/9653
dc.identifier.volume22
dc.identifier.wosWOS:001507199300001
dc.language.isoen
dc.publisherGALENOS PUBL HOUSE
dc.relation.ispartofTURK J OBSTET GYNECO
dc.subjectOvary
dc.subjectfollicle count
dc.subjectanti-m & uuml
dc.subjectllerian hormone
dc.subjectVEGFR-2
dc.subjectimmunohistochemical analysis
dc.subjectoxidative stress
dc.titleAssessing the potential of nifedipine and resveratrol to enhance ovarian viability in conjunction with detorsion treatment: A rat ovarian torsion model study
dc.typeArticle

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