Effect of hydronephrosis on survival in advanced stage cervical cancer

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dc.contributor.authorGöklü, Mehmet Rauf
dc.contributor.authorSeçkin, Kerem Doğa
dc.contributor.authorToğrul, Cihan
dc.contributor.authorGöklü, Yasemin
dc.contributor.authorTahaoğlu, Ali Emre
dc.contributor.authorÖz, Murat
dc.contributor.authorErtaş, İbrahim Egemen
dc.date.accessioned2019-05-13T09:04:25Z
dc.date.available2019-05-13T09:04:25Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBackground: Hydronephrosis is frequently encountered in advanced stage cervical cancers, and may be associated with mortality. In the present study, we aimed to demonstrate the effect of hydronephrosis on survival in patients with inoperable advanced stage cervical cancer. Materials and Methods: The study data were acquired by retrospective analysis of the patient records belonging to 165 women with FIGO (International Federation of Gynecology and Obstetrics) stage-IIIB or more advanced cervical cancer, which were not surgical candidates. Parameters including patient age, pathological diagnosis, disease stage, pelvic sidewall extension, presence of hydronephrosis and administration of chemoradiation were analyzed. Further, the effects of these variables on survival were assessed. P values less than 0.05 were considered statistically significant. Results: The distribution of the study patients according to disease stage was as follows: 131 (79.4%) had stage-IIIB, 18 (10.9%) had stage-IVB and 16 (% 9.7) patients had stage-IVA disease. Hydronephrosis was not evident in 91 (55.2%) of these patients, whereas 41 (24.8%) had unilateral and 33 (20%) patients had bilateral hydronephrosis. When compared to mean survival in patients who did not have hydronephrosis, survival was significantly shortened in patients who had bilateral and unilateral hydronephrosis (p < 0.05). There was no significant survival difference between patients with unilateral and bilateral hydronephrosis (p>0.05). Although patient age, pathological type, pelvic involvement, and chemotherapy treatment rates were similar (p>0.05), radiotherapy requirement rate and disease stage were significantly different among the study groups (p<0.05). Conclusions: Hydronephrosis was found to be a significant predictor of poor survival in patients with advanced stage cervical cancer, irrespective of unilateral or bilateral involvement.While waiting for future studies with larger sample sizes, we believe that the FIGO stages in advanced cervical cancer could further be stratified into subgroups according to presence or absence of hydronephrosis.
dc.identifier.citationGöklü, M. R., Seçkin, K. D., Toğrul, C., Göklü, Y., Tahaoğlu, A. E., Öz, M., Ertaş, İ. E. (2015). Effect of hydronephrosis on survival in advanced stage cervical cancer. Asian Pacific Journal of Cancer Prevention, 16(10), 4219-4222.
dc.identifier.doi10.7314/APJCP.2015.16.10.4219
dc.identifier.endpage4222en_US
dc.identifier.issn1513-7368
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage4219en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2015.16.10.4219
dc.identifier.urihttps://hdl.handle.net/11491/1587
dc.identifier.volume16en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAsian Pacific Organization for Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCervical Canceren_US
dc.subjectHydronephrosisen_US
dc.subjectStageen_US
dc.subjectSurvivalen_US
dc.titleEffect of hydronephrosis on survival in advanced stage cervical cancer
dc.typeArticle

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