Retinal Nerve Fiber Layer Thickness in Opioid Abusers

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dc.authoridSAHIN, TAYFUN / 0000-0003-2319-0807
dc.authoridkaradere, mehmet emrah / 0000-0002-1404-9839
dc.authorwosidSAHIN, TAYFUN / ABI-3692-2020
dc.contributor.authorKaradere, M. Mehmet
dc.contributor.authorSahin, Tayfun
dc.contributor.authorCobanoglu, Ebru
dc.contributor.authorYildiz, Veysi
dc.date.accessioned2021-11-01T15:03:14Z
dc.date.available2021-11-01T15:03:14Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractBackground: Opioids are addictive substances that have been shown to have neurotoxic effects on the brain. These neurotoxic effects may be associated with retinal nerve fiber layer (RNFL) thickness. This study aims to examine retinal neural fiber layer thickness by optical coherence tomography (OCT) among opioid addicts. Methods: Therefore, both eyes of the 45 participants who met the diagnosis of opioid addiction according to DSM-5 (age:26.13 +/- 6.20 years) and 45 healthy control groups (age:28.87 +/- 9.04 years) were examined in seven quadrants (superior temporal, superior nasal, temporal, nasal, inferior temporal, inferior nasal quadrants and global RNFL thickness) with OCT. Results: Mean RNFL thicknesses in any quadrant did not differ statistically significantly between the groups (p>0.05). Furthermore, there was no statistically significant correlation between the duration of substance use and RNFL thicknesses. There is a statistically significant inverse correlation that has been found between the daily amount of substance use (gr) and RNFL thicknesses in the right eye temporal inferior (r: - 0,499) and temporal superior (r: - 0,351) and left eye nasal inferior (r: - 0,387) quadrants, whereas there was not any statistically significant correlation in other quadrants. Conclusions: This study suggests that RNFL thickness may be the same as healthy controls for several reasons in opioid addicts. It would be appropriate for this to be confirmed by broader studies and for its mechanism to be investigated.
dc.identifier.doi10.5455/PCP.20200702123911
dc.identifier.endpage373en_US
dc.identifier.issn2475-0573
dc.identifier.issn2475-0581
dc.identifier.issue4en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://doi.org/10.5455/PCP.20200702123911
dc.identifier.urihttps://hdl.handle.net/11491/7031
dc.identifier.volume30en_US
dc.identifier.wosWOS:000604931500005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherTurkish Assoc Psychopharmacology
dc.relation.ispartofPsychiatry And Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectoptic coherence tomographyen_US
dc.subjectopioiden_US
dc.subjectheroinen_US
dc.subjectretinal nerve fiber layeren_US
dc.titleRetinal Nerve Fiber Layer Thickness in Opioid Abusers
dc.typeArticle

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